Osthole 98%

Fructus cnidii (Common Cnidium) is annual herb,height 30-80cm. Fructus cnidii leaf is alternate,compundumbel inflorescence.Cremocarp, ellipsoidal, 2-4 mm long, about 2 mm in diameter. Externally greyish-yellow or greyish-brown; with 2outcurved stylopods at the summit, and sometimes with a fine fruit stalk at the base. Dorsal surface of mericarps with five thin and longitudinal ridges, commissural surface flattened, with two brown and slightly raised longitudinal ribs. Fructus cnidii’s pericarp lax and fragile, easily rubbed off, seed small, greyish-brown and oily. Odour, aromatic; taste, pungent, cool and numb.

Osthol, also known as methoxyparsley, parsley methyl ether, is a coumarin compounds, in the umbrella plant osthol content is high, so called osthol. In 1909, Herzog and Krohn first obtained the compound osthol from the roots of the umbrella plant europhus. At present, it is widely found in plants, mainly in umbelliferae and rutaceae, and also in a few compositae and legumes.
Commercial cnidium cnidium is mainly extracted from dried and ripe fruit of cnidium cnidium. Cnidium is mainly distributed in guangxi, jiangsu, anhui, shandong, hebei, etc. Because of its various biological activities, cnidium is widely used in cosmetics,medicine and agriculture.

Product Name:Osthole 98%

Specification：98% by HPLC

Latin Name:C.monnieri (L.) Cusson

Botanic Source:Common Cnidium Fruit Extract

CAS No:484-12-8

Plant Part Used:Seed

Colour:Brown to white fine powder with characteristic odor and taste

GMO Status:GMO Free

Packing: in 25kgs fiber drums

Storage:Keep container unopened in cool, dry place,Keep away from strong light

Shelf Life:24 months from date of production

Functions:

-Osthole can increase sperm secretion, stimulate sexual desire and has aphrodisiac action

-Osthole can dry dampness and kills worms,expel cold and expel the wind,warm the kidney to

 strengthen yin.

-Osthole has the function of relieving asthma and antifungus, antivirus.

Antiarrhythmic effect

Water extract and total coumadin from fructus cnidium have obvious preventive effects on chloroform induced ventricular fibrillation in mice and calcium chloride induced ventricular fibrillation in rats. Fructus cnidium and zanthoxylum acetaminophen also have this pharmacological effect and can improve ventricular electrofibrillation threshold in rabbits. The water extract, total coumarin, cnidium, and phenols of zanthoxylum had significant inhibitory effects on the flow of sodium ions in the myocardial cell membrane.

Antihypertensive, inhibition of vascular dilatation

Osthol had a dose-dependent negative inotropic effect on the left atrium of isolated guinea pigs and a negative frequency effect on the left atrium of isolated guinea pigs. In addition to the polarization induced by norepinephrine, CaCl2 and high K+, the aorta contraction dose-response curve of rabbits was shifted to the right and the maximum response was decreased, indicating the role of biosynthetic compound in relaxing vascular smooth muscle. Fructus cnidium has a certain antihypertensive effect.

Effects on respiratory system

Cnidium monnieri total coumarin with relaxation by drugs (histamine and acetylcholine) caused by bronchial spasms and diastole bronchus role directly, this function can be B – adrenaline receptor blockers block by propranolol, mice after total coumarin cnidium monnieri, obviously increase the amount of phenol red drain in the body, shows strong expectoranting action.

Anti-inflammatory effects

Cnidium cnidium and phenolic zanthoxylum could inhibit the ear shell swelling of mice caused by xylene and the increase of capillary permeability in abdominal cavity caused by acetic acid. Osthol and acetonol had significant inhibitory effects on foot swelling in rats and rats with bilateral adrenal resection. Osthol could also reduce the PGE content in the inflammatory tissues of the swollen part of the foot in rats, but osthol did not affect the PGE content in the inflammatory tissues of the swollen part of the foot in rats.

Effects on the nervous system

The total coumarin of cnidium cnidium has an inhibitory effect on central nervous system. Osthol can significantly enhance the hypnotic effect of pentobarbital sodium on subthreshold hypnotic dose in mice, and this hypnotic effect is dose-related. Cnidium cnidium can promote the learning and memory of mice, and significantly improve the memory acquisition, consolidation and directAntiarrhythmic effect

Water extract and total coumadin from fructus cnidium have obvious preventive effects on chloroform induced ventricular fibrillation in mice and calcium chloride induced ventricular fibrillation in rats. Fructus cnidium and zanthoxylum acetaminophen also have this pharmacological effect and can improve ventricular electrofibrillation threshold in rabbits. The water extract, total coumarin, cnidium, and phenols of zanthoxylum had significant inhibitory effects on the flow of sodium ions in the myocardial cell membrane.

Antihypertensive, inhibition of vascular dilatation

Osthol had a dose-dependent negative inotropic effect on the left atrium of isolated guinea pigs and a negative frequency effect on the left atrium of isolated guinea pigs. In addition to the polarization induced by norepinephrine, CaCl2 and high K+, the aorta contraction dose-response curve of rabbits was shifted to the right and the maximum response was decreased, indicating the role of biosynthetic compound in relaxing vascular smooth muscle. Fructus cnidium has a certain antihypertensive effect.

Effects on respiratory system

Cnidium monnieri total coumarin with relaxation by drugs (histamine and acetylcholine) caused by bronchial spasms and diastole bronchus role directly, this function can be B – adrenaline receptor blockers block by propranolol, mice after total coumarin cnidium monnieri, obviously increase the amount of phenol red drain in the body, shows strong expectoranting action.

Anti-inflammatory effects

Cnidium cnidium and phenolic zanthoxylum could inhibit the ear shell swelling of mice caused by xylene and the increase of capillary permeability in abdominal cavity caused by acetic acid. Osthol and acetonol had significant inhibitory effects on foot swelling in rats and rats with bilateral adrenal resection. Osthol could also reduce the PGE content in the inflammatory tissues of the swollen part of the foot in rats, but osthol did not affect the PGE content in the inflammatory tissues of the swollen part of the foot in rats.

Effects on the nervous system

The total coumarin of cnidium cnidium has an inhibitory effect on central nervous system. Osthol can significantly enhance the hypnotic effect of pentobarbital sodium on subthreshold hypnotic dose in mice, and this hypnotic effect is dose-related. Cnidium cnidium can promote the learning and memory of mice, and significantly improve the memory acquisition, consolidation and direction discrimination of mice.

Anti – mutagenesis, anti – cancer effect

Cnidium, parsley b, bergamot lactone, isorhein, zanthoxylum acetaminophen and zanthoxylum toxin have high activity in inhibiting the mutagenesis of aflatoxin B1. Water extract of cnidium could inhibit S130 sarcoma, prolong survival days and inhibit tumor growth.

Anti – mutagenesis, anti – cancer effect

Cnidium, parsley b, bergamot lactone, isorhein, zanthoxylum acetaminophen and zanthoxylum toxin have high activity in inhibiting the mutagenesis of aflatoxin B1. Water extract of cnidium could inhibit S130 sarcoma, prolong survival days and inhibit tumor growth.

Applications:

Osthole is widely used in fields of heath products.Osthole can be used as the tonic product on the male impotence, active ingredients of medicines for gynecological diseases.

Osthole is widely used in fields of medicine products. Osthole also is used as the tonic product on the acute exudative skin disease.

Several raw material suppliers as supply assurance.Strong Cooperative Institutions to supportInstitute of botany/Institution of microbiology/Academy of Science and Technology/University