Spermidine Bulk Powder
Product Name：Spermidine Other Name:N-(3-Aminopropyl)-1,4-butanediamine；1,8-Diamino-4-azaoctane CAS No.:334-50-9 EINECS N0.:204-689-0 Assay: 99% Botanical Source:Wheat Germ Extract Appearance:White Fine powder Melting Point:22～25℃ GMO Status:GMO Free Packing: in 25kgs fiber drums Storage:Keep container unopened in cool, dry place,Keep away from strong light Shelf Life:24 months from date of production。
Spermidine is a small molecule with a molecular weight of 145.25, and unique CAS Registry Number as 124-20-9. It’s stable at room temperature. The color of Spermidine-rich wheat germ extract is white to yellowish powder, while for synthetic spermidine powder, the color is white to off-white. Spermidine is also available in the chloride form as spermidine trihydrochloride or spermidine 3 HCL (CAS 334-50-9).
Both spermine and spermidine are polyamines involved in cellular metabolism. Popular polyamines include agmatine (AGM), putrescine (PUT), cadaverine (CAD), spermine (SPM), and spermidine (SPD). Spermine is a crystalline powder compound and is related to spermidine, but is not the same.
Spermidine is a precursor to other polyamines, like spermine and thermospermine. The chemical name of spermidine is N-(3-aminopropyl) butane-1,4-diamine while the CAS number of spermine is 71-44-3 (free base) and 306-67-2 (tetrahydrochloride).
There are two main ways for obtaining bulk spermidine, one is from natural foods, the other is from chemical synthesis.
There are several foods high in spermidine, such as wheat germ extract, fruits, grapefruit, yeast, mushrooms, meat, soybeans, cheese, Japanese Natto (fermented soybeans), green peas, rice bran, cheddar, etc. That’s why the Mediterranean diet is so popular since a high polyamine content in it。
Spermidine is best known for its ability to trigger the cellular process of autophagy, mimicking one of the key benefits from the popular health practice of fasting and caloric restriction. Autophagy is the most powerful benefit of fasting. The best part is that spermidine is able to trigger autophagy without fasting.
Various mechanisms of action of spermidine are under research for its longevity benefit in mammals. Autophagy is the main mechanism, while other pathways, including inflammation reduction, lipid metabolism, and regulation of cell growth, proliferation and death are also studied by scientists.
The proved main health benefits of spermidine supplements are for anti-aging and hair growth.
Spermidine for anti-aging and longevity
Spermidine levels decrease with age. Supplementation can replenish these levels and induce autophagy, thus renew cells and extend lifespan.
Spermidine works to support brain and heart health. Spermidine is believed to help reduce the onset of neurodegenerative and age-related diseases. Spermidine can support cellular renewal and help cells stay young and healthy.
Spermidine for human hair growth
A spermidine-based nutritional supplement can prolong the anagen phase in humans, and therefore might be beneficial for hair loss conditions. Further studies are needed to evaluate its effects in specific different clinical settings.
For more info, please read the study here: A spermidine-based nutritional supplement prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-blind study
Other possible benefits may include:
- Promote fat loss and healthy weight
- Normalize bone density
- Reduce age-dependent muscular atrophy
- Enhance the growth of hair, skin, and nails
Supplements containing spermidine
The majority of spermidine supplements on the market are spermidine-rich wheat germ extract. spermidine tablets and spermidine capsules are available.