Chotsitsa cha Mtengo wa Utsi

Mutu: Chotsitsa cha Mtengo Waukulu wa Utsi 98%Fisetinndi HPLC | Chowonjezera Chachilengedwe Choletsa Kukalamba ndi Choletsa Kukalamba
Mawu Ofunika:Fisetin98%, HPLC Yotsimikizika, Chotsitsa cha Mtengo wa Utsi, Antioxidant Yachilengedwe, Chowonjezera Choletsa Kukalamba

1. Chidule cha Zamalonda

Smoke Tree Extract 98% Fisetin ndi mankhwala achilengedwe oyera kwambiri ochokera kuCotinus coggygria(Smoke Tree), yokhazikika pa 98% ya Fisetin kudzera muukadaulo wapamwamba wa High-Performance Liquid Chromatography (HPLC). Fisetin (C₁₅H₁₀O₆) ndi flavonoid yodziwika bwino chifukwa cha mphamvu zake zotsutsana ndi ma antioxidants, zotsutsana ndi kutupa, komanso zotsutsana ndi senogenic, zomwe zimapangitsa kuti ikhale chinthu chofunikira kwambiri mu zakudya, zodzoladzola, ndi mankhwala.

2. Mafotokozedwe Ofunika

• Chogwiritsira Ntchito: Fisetin ≥98% (HPLC)
• Nambala ya CAS:528-48-3
• Fomula ya Molekyulu: C₁₅H₁₀O₆
• Maonekedwe: Ufa wachikasu wowala
• Kusungunuka: Kusungunuka mu ethanol, DMSO; kusungunuka pang'ono m'madzi
• Chitsime cha Chomera:Cotinus coggygriamasamba ndi tsinde
• Ziphaso: GMP, ISO 9001, COA (Satifiketi Yowunikira) yoperekedwa

3. Njira Yopangira & Kuwongolera Ubwino

3.1 Kuchotsa Zinthu Mosatha

Timagwiritsa ntchito njira yochotsera CO₂ yofunika kwambiri kuti titsimikizire kuti Fisetin ndi yotetezeka ku chilengedwe komanso yopanda zosungunulira, ndikusunga umphumphu wake.

3.2 Kuyeretsa ndi Kutsimikizira HPLC

• Mikhalidwe ya Chromatographic:
  • Mzere: ZORBAX C18 (4.6×150 mm, 5 μm)
  • Gawo Loyenda: Kutulutsa kwa gradient ndi 5% acetic acid (Solvent A) ndi acetonitrile (Solvent B)
  • Kuzindikira: Kutengera kwa UV pa 360 nm, nthawi yosungira ≈11.6–12.6 mphindi (yogwirizana ndi muyezo wa Fisetin)
• Kuyeza kwa Mass Spectrometry (MS):
  • Ma Ion Mode Abwino: m/z 287.05487 (C₁₅H₁₁₁O₆⁺)
  • Mawonekedwe a Ion Oyipa: m/z 285.03997 (C₁₅H₉O₆⁻)
  • Mapangidwe Ogawikana: Ogwirizana ndi miyezo yeniyeni ya Fisetin kuti atsimikizire kapangidwe ka mamolekyu.

3.3 Chitsimikizo cha Kukhazikika

Fisetin imakhudzidwa ndi kuwala ndi kutentha. Chogulitsa chathu chimayikidwa mu galasi la amber lotetezedwa ndi UV ndi mankhwala oyeretsera kuti chikhale chokhazikika panthawi yosungira ndi kunyamula.

4. Mapulogalamu ndi Mapindu

4.1 Kuletsa Ukalamba ndi Kukalamba

Fisetin imagwira ntchito ngati wothandizira wa selo, pochotsa maselo okalamba omwe amagwirizanitsidwa ndi matenda okhudzana ndi ukalamba. Kafukufuku akuwonetsa kuti imawonjezera moyo wa maselo mwa kuyambitsa njira za SIRT1.

4.2 Chitetezo cha Mitsempha

Amadutsa chotchinga cha magazi ndi ubongo kuti achepetse kupsinjika kwa okosijeni, zomwe zitha kuchepetsa kukula kwa matenda a Alzheimer's ndi Parkinson's.

4.3 Kafukufuku Wotsutsana ndi Kutupa ndi Khansa

Amasintha njira za NF-κB ndi COX-2, ndikuletsa ma cytokines omwe amayambitsa kutupa. Deta yoyambirira imasonyeza kuti apoptosis imayamba m'maselo a khansa.

4.4 Zodzoladzola

Mankhwala opangidwa ndi khungu amathandiza kuti khungu likhale lolimba komanso limachepetsa kuwonongeka kwa UV mwa kuchepetsa ma free radicals.

5. Kutsatira Malamulo ndi Chitetezo

• Deta ya poizoni: LD₅₀ >2000 mg/kg (yomwe imaperekedwa pakamwa, makoswe), yomwe imagawidwa ngati yopanda poizoni.
• Kutsatira Malamulo: Kukwaniritsa malangizo a USP, EP, ndi FDA okhudza zowonjezera zakudya.
• Zopanda Allergen: Zopanda GMO, zopanda gluten, komanso zosagwirizana ndi zamasamba.

6. Kulongedza ndi Kuyitanitsa

• Kukula Komwe Kulipo: 25 kg/ng'oma (yaikulu), 1 kg (chitsanzo)
• MOQ: 1 kg (zitsanzo); 25 kg pa maoda ambiri.
• Kutumiza Padziko Lonse: DHL/FedEx yokhala ndi njira zozizira zogwiritsira ntchito madera omwe kutentha kumasinthasintha.

7. Mafunso Ofunsidwa Kawirikawiri

Q: Kodi chiyero chimatsimikiziridwa bwanji?
A: Gulu lililonse limayesedwa kawiri kudzera mu HPLC ndi MS, ndipo COA imaperekedwa.

Q: Kodi fisetin ingalowe m'malo mwa quercetin?
A: Ngakhale kuti zonsezi ndi flavonoids, fisetin imasonyeza bioavailability yabwino kwambiri komanso zotsatira zake zimakhala zotsutsana ndi khansa.

Q: Nthawi yogwiritsira ntchito?
A: Miyezi 24 ikasungidwa pa ≤25°C m'zidebe zotsekedwa komanso zosapsa kuwala.

8. N’chifukwa Chiyani Tiyenera Kusankha Ife?

• Ukatswiri wa Kafukufuku ndi Kupititsa Patsogolo: Kugwiritsa ntchito njira zopangira zinthu (monga P450 monooxygenase optimization) kuti pakhale phindu lalikulu.
• Kusintha: Kuyera kosinthika (50% ~ 98%) ndi ntchito za OEM zomwe zikupezeka.
• Kukhazikika: Kutulutsa madzi a ethanol kumagwirizana ndi mfundo za chemistry yobiriwira.

9. Maumboni

1. Kupanga Njira Yatsopano Yopangira Fisetin (2024).
2. Kusanthula kwa HPLC kwa Flavonoids muSophora japonica(Yang et al., 2017).
3. A. integrifoliaKufotokozera Zotsalira (Makalata a Sayansi ya Zamankhwala, 2020)