I-Smoke Tree Extract

Isihloko: I-Premium Premium Smoke Tree Extract 98%I-Fisetinnge-HPLC | I-Antioxidant Yemvelo Nesengezo Sokuguga
Amagama angukhiye:I-Fisetin98%, I-HPLC Iqinisekisiwe, Isizinda Sesihlahla Sentuthu, I-Antioxidant Yemvelo, Isengezo Sokuguga

1. Uhlolojikelele lomkhiqizo

I-Smoke Tree Extract 98% I-Fisetin iyinhlanganisela yemvelo ehlanzekile kakhulu etholakala kuyoI-Cotinus coggygria(Isihlahla Sentuthu), silinganiswe ku-98% we-Fisetin ngobuchwepheshe obuthuthukisiwe be-High-Performance Liquid Chromatography (HPLC). I-Fisetin (C₁₅H₁₀O₆) iyi-flavonoid edume ngezici zayo ezinamandla ze-antioxidant, anti-inflammatory, kanye ne-senolytic, okuyenza ibe isithako esifunwa kakhulu ekwenziweni komsoco, izimonyo, kanye nokwakhiwa kwemithi .

2. Imininingwane Ebalulekile

• Isithako Esisebenzayo: I-Fisetin ≥98% (HPLC)
• Inombolo ye-CAS:528-48-3
• I-Molecular Formula: C₁₅H₁₀O₆
• Ukubukeka: Impushana ephuzi ekhanyayo
• I-Solubility: I-Soluble ku-ethanol, i-DMSO; incibilika kancane emanzini
• Umthombo Wesitshalo:I-Cotinus coggygriaamaqabunga neziqu
• Izitifiketi: I-GMP, i-ISO 9001, i-COA (Isitifiketi Sokuhlaziya) inikeziwe

3. Inqubo Yokukhiqiza Nokulawula Ikhwalithi

3.1 Isizinda Esimeme

Sisebenzisa isizinda se-CO₂ esibucayi kakhulu ukuze siqinisekise ukuhlukaniswa kwe-Fisetin-eco-friendly kanye ne-solvent-free, ukulondoloza ubuqotho bayo be-bioactive.

3.2 Ukuhlanzwa Nokuqinisekiswa kwe-HPLC

• Izimo zeChromatographic:
  • Ikholomu: ZORBAX C18 (4.6×150 mm, 5 μm)
  • Isigaba Seselula: Ukukhishwa kwe-Gradient nge-acetic acid engu-5% (I-Solvent A) ne-acetonitrile (I-Solvent B)
  • Ukutholwa: Ukumunca kwe-UV ku-360 nm, isikhathi sokugcina ≈11.6–12.6 min (ngokuhambisana nezinga le-Fisetin)
• I-Mass Spectrometry (MS):
  • Imodi ye-Ion Enhle: m/z 287.05487 (C₁₅H₁₁O₆⁺)
  • Imodi ye-Ion Engalungile: m/z 285.03997 (C₁₅H₉O₆⁻)
  • Amaphethini Okuhlukana: Afaniswe namazinga ayiqiniso e-Fisetin ukuze kuqinisekiswe ukwakheka kwamangqamuzana .

3.3 Ukuqinisekisa Ukuzinza

I-Fisetin izwela ukukhanya nokushisa. Umkhiqizo wethu ufakwe engilazini yenhlaka evikelwe yi-UV enama-desiccants ukuze kuqinisekiswe ukuzinza ngesikhathi sokugcina nokuhamba.

4. Izicelo Nezinzuzo

4.1 I-Anti-Aging & Senescence

I-Fisetin isebenza njenge-ejenti ye-senolytic, isusa ngokukhetha amaseli e-senescent axhumene nezifo ezihlobene nobudala. Ucwaningo lubonisa ukuthi ithuthukisa ubude bempilo kumamodeli ngokwenza kusebenze izindlela ze-SIRT1 .

4.2 I-Neuroprotection

Weqa umgoqo wegazi nobuchopho ukuze unciphise ingcindezi ye-oxidative, engase yehlise ukuqhubekela phambili kwe-Alzheimer kanye ne-Parkinson.

4.3 Ucwaningo Lokulwa Nokuvuvukala Nomdlavuza

Imodulates i-NF-κB kanye ne-COX-2 izindlela, ivimbele ama-cytokines ane-pro-inflammatory. Idatha ye-preclinical iphakamisa ukungeniswa kwe-apoptosis kumaseli omdlavuza.

4.4 Izimonyo

Ukwakhiwa kwezihloko kuthuthukisa ukunwebeka kwesikhumba futhi kunciphise umonakalo obangelwa yi-UV ngokuqeda ama-radicals mahhala .

5. Ukuthobelana Nokuphepha

• Idatha Yobuthi: LD₅₀ >2000 mg/kg (ngomlomo, igundane), ehlukaniswa njengengenabo ubuthi.
• Ukuthobela Umthetho: Ihlangabezana neziqondiso ze-USP, EP, kanye ne-FDA ngezithako zokudla.
• I-Allergen-Free: Okungeyona i-GMO, i-gluten-free, kanye ne-vegan-friendly.

6. Ukupakisha noku-oda

• Osayizi Abatholakalayo: 25 kg/isigubhu (inqwaba), 1 kg (isampula)
• I-MOQ: 1 kg (amasampula); 25 kg ngama-oda amaningi.
• I-Global Shipping: I-DHL/FedEx enezinketho zamaketanga abandayo ezifundeni ezingezwani nezinga lokushisa.

7. Imibuzo Evame Ukubuzwa

Q: Buqinisekiswa kanjani ubumsulwa?
A: Iqoqo ngalinye lihlolwa okukabili nge-HPLC ne-MS, kuhlinzekwe nge-COA .

Umbuzo: Ingabe i-fisetin ingakwazi ukuthatha indawo ye-quercetin?
A: Nakuba womabili engama-flavonoid, i-fisetin ibonisa ukutholakala kwe-bioavailability okuphakeme kanye nemiphumela ye-senolytic.

Umbuzo: Impilo yeshelufu?
A: Izinyanga ezingama-24 uma zigcinwe ku-≤25°C ezitsheni ezivaliwe, ezimelana nokukhanya.

8. Kungani Usikhethe?

• Ubungcweti be-R&D: Ukusebenzisa izindlela ze-biosynthesis (isb, i-P450 monooxygenase optimization) ukuze uthole isivuno esiphezulu .
• Ukwenza ngokwezifiso: Ubumsulwa obulungisekayo (50%~98%) kanye nezinsizakalo ze-OEM ziyatholakala.
• Ukusimama: Ukukhishwa kwamanzi e-Ethanol kuhambisana nezimiso zamakhemikhali aluhlaza .

9. Izikhombo

1. Umhlangano weNovel Biosynthetic Pathway for Fisetin Production (2024).
2. Ukuhlaziywa kwe-HPLC kwe-Flavonoids kuI-Sophora japonica(Yang et al., 2017).
3. A. integrifoliaI-Extract Profileing (Izincwadi Zesayensi Yezinto Eziphilayo, 2020)