I-Smoke Tree Extract

Isihloko: I-Premium Smoke Tree Extract engu-98%I-Fisetinngu-HPLC | Isengezo Semvelo Sokulwa Nokulwa Nokuguga
Amagama angukhiye:I-Fisetin98%, Iqinisekisiwe yi-HPLC, I-Smoke Tree Extract, i-Natural Antioxidant, Isengezo Sokulwa Nokuguga

1. Ukubuka Konke Komkhiqizo

I-Smoke Tree Extract engu-98% i-Fisetin iyinhlanganisela yemvelo emsulwa kakhulu etholakala ku-I-Cotinus coggygria(Smoke Tree), efakwe ku-98% we-Fisetin ngokusebenzisa ubuchwepheshe obuthuthukisiwe be-High-Performance Liquid Chromatography (HPLC). I-Fisetin (C₁₅H₁₀O₆) iyi-flavonoid eyaziwa ngezakhiwo zayo ezinamandla ze-antioxidant, anti-inflammatory, kanye ne-senolytic, okwenza ibe yisithako esifunwa kakhulu kuma-nutraceuticals, izimonyo, kanye nemithi.

2. Imininingwane Eyinhloko

• Isithako Esisebenzayo: I-Fisetin ≥98% (HPLC)
• Inombolo ye-CAS:528-48-3
• Ifomula Yamamolekyuli: C₁₅H₁₀O₆
• Ukubukeka: Impuphu ephuzi ekhanyayo
• Ukuncibilika: Kuncibilika ku-ethanol, i-DMSO; kuncibilika kancane emanzini
• Umthombo Wesitshalo:I-Cotinus coggygriaamaqabunga neziqu
• Izitifiketi: GMP, ISO 9001, COA (Isitifiketi Sokuhlaziya) esinikeziwe

3. Inqubo Yokukhiqiza Nokulawula Ikhwalithi

3.1 Ukukhishwa Okuqhubekayo

Sisebenzisa ukukhipha i-CO₂ okubaluleke kakhulu ukuqinisekisa ukuhlukaniswa kwe-Fisetin okuhambisana nemvelo nokungenazo izinyibilikisi, silondoloze ubuqotho bayo obusebenzayo.

3.2 Ukuhlanzwa Nokuqinisekiswa kwe-HPLC

• Izimo ze-Chromatographic:
  • Ikholomu: ZORBAX C18 (4.6×150 mm, 5 μm)
  • Isigaba Esihambayo: Ukususwa kwe-gradient nge-5% acetic acid (i-Solvent A) kanye ne-acetonitrile (i-Solvent B)
  • Ukutholwa: Ukumuncwa kwe-UV ku-360 nm, isikhathi sokugcinwa ≈11.6–12.6 min (kuhambisana ne-Fisetin standard)
• I-Mass Spectrometry (MS):
  • Imodi ye-Ion Enhle: m/z 287.05487 (C₁₅H₁₁₁O₆⁺)
  • Imodi ye-Ion Engalungile: m/z 285.03997 (C₁₅H₉O₆⁻)
  • Amaphethini Okuhlukana: Ahambisana nezindinganiso ze-Fisetin zangempela ukuqinisekisa ukwakheka kwama-molecule.

3.3 Ukuqinisekiswa Kokuzinza

I-Fisetin iyazwela ekukhanyeni nasekushiseni. Umkhiqizo wethu upakishwe ngengilazi ye-amber evikelwe yi-UV kanye nama-desiccant ukuqinisekisa ukuzinza ngesikhathi sokugcina nokuthuthwa.

4. Izicelo kanye nezinzuzo

4.1 Ukulwa Nokuguga Nokuguga

I-Fisetin isebenza njenge-senolytic agent, isusa ngokukhetha amaseli asebekhulile ahlobene nezifo ezihlobene nokuguga. Izifundo zibonisa ukuthi ithuthukisa isikhathi sokuphila kumamodeli ngokusebenzisa izindlela ze-SIRT1.

4.2 Ukuvikelwa Kwezinzwa

Idlula isithiyo segazi nobuchopho ukuze inciphise ukucindezeleka kwe-oxidative, okungenzeka inciphise ukuqhubeka kwesifo i-Alzheimer's kanye ne-Parkinson's.

4.3 Ucwaningo Lokulwa Nokuvuvukala Nomdlavuza

Iguqula izindlela ze-NF-κB kanye ne-COX-2, ivimbela ama-cytokine abangela ukuvuvukala. Imininingwane yangaphambi kokuhlolwa iphakamisa ukuqaliswa kwe-apoptosis kumaseli omdlavuza.

4.4 Izinto Zokuhlobisa

Izakhi zokwenziwa zithuthukisa ukuqina kwesikhumba futhi zinciphise umonakalo obangelwa yi-UV ngokuqeda ama-free radicals.

5. Ukuthobela Nokuphepha

• Idatha Yobuthi: LD₅₀ >2000 mg/kg (ngomlomo, igundane), ehlukaniswe njengengeyona enobuthi.
• Ukuthobela Imithetho: Kuhlangabezana neziqondiso ze-USP, EP, kanye ne-FDA zezithako zokudla.
• Akuna-Allergen: Akuyona i-GMO, ayinayo i-gluten, futhi ayidingi i-vegan.

6. Ukupakisha Noku-oda

• Osayizi Abatholakalayo: 25 kg/isigubhu (ngobuningi), 1 kg (isampula)
• I-MOQ: 1 kg (amasampula); 25 kg yama-oda amaningi.
• Ukuthunyelwa Komhlaba Wonke: I-DHL/FedEx enezinketho zochungechunge olubandayo lwezindawo ezizwela amazinga okushisa.

7. Imibuzo Evame Ukubuzwa

Q: Ubumsulwa buqinisekiswa kanjani?
A: Iqembu ngalinye lihlolwa kabili nge-HPLC kanye ne-MS, kanti i-COA inikezwa.

Q: Ingabe i-fisetin ingathatha indawo ye-quercetin?
A: Nakuba zombili ziyi-flavonoids, i-fisetin ibonisa ukutholakala kwe-bioavailability okuphezulu kanye nemiphumela ye-senolytic.

Q: Isikhathi sokuphelelwa yisikhathi?
A: Izinyanga ezingama-24 uma zigcinwa ku-≤25°C ezitsheni ezivaliwe, ezingamelani nokukhanya.

8. Kungani Kufanele Sikhethe?

• Ubuchwepheshe be-R&D: Ukusebenzisa izindlela ze-biosynthesis (isb., ukulungiswa kwe-P450 monooxygenase) ukuze uthole isivuno esiphezulu.
• Ukwenza ngokwezifiso: Ubumsulwa obulungisekayo (50% ~ 98%) kanye nezinsizakalo ze-OEM ziyatholakala.
• Ukusimama: Ukukhishwa kwamanzi e-ethanol kuhambisana nezimiso ze-chemistry eluhlaza.

9. Izinkomba

1. Ukuhlanganiswa Kwendlela Entsha Yokwenziwa Kwezinto Zokwenziwa Kwezinto Zokwenziwa Kwezinto Zokwenziwa Kwezinto Zokwenziwa Kwezinto Zokwenziwa Kwezinto Zokwenziwa (2024).
2. Ukuhlaziywa kwe-HPLC kwama-Flavonoid kuI-Sophora japonica(Yang et al., 2017).
3. A. integrifoliaIphrofayili Yeziqephu (Izincwadi Zesayensi Yezokwelapha, 2020)