10-Deacetylbaccatin III (10-DAB)

10-Deacetylbaccatin III (10-DAB) Sawirka la soo bandhigay
  • 10-Deacetylbaccatin III (10-DAB)

Sharaxaad Gaaban:

10-Deacetylbaccatin III (C29H36O10) waa diterpenoid bioactive ah oo si dabiici ah looga soo saaro cirbadaha iyo jilifTaksinoocyada (geedaha yew). Iyada oo horudhac muhiim ah u ah nus-ku-samaynta paclitaxel, docetaxel, iyo wakiilada kale ee kiimikaad-ku-salaysan ee taxan-ku-salaysan, 10-DAB waxaa si weyn looga faa'iidaystaa R&D-da dawooyinka iyo soo-saarka daawada oncology.

10-Deacetylbaccatin III, oo sidoo kale loo yaqaan 10-DAB ama 10-DAB III, waa isku-dhafan dabiici ah oo dabiici ah oo si dhow ula xiriira oo ka go'doonsan cirbadaha la qalajiyey iyo laamo yaryar oo geed yuurub ah (Taxus baccata) . pacitaxel (taxol); cabazitaxel. 10-10-deacetylbaccatin III ayaa la ogaadey in ay si xushmad leh u joojiso koritaanka L. DONOVANI intracellular amastigotes gudaha J774 murine macrophages in vitro at nanomolar fiirsashada oo leh IC (50) qiimaha 70 nM.


  • Qiimaha FOB:US 5 - 2000 / KG
  • Tirada Dalbashada Min.1 KG
  • Awood-siinta:10000 KG/Bishii
  • Dekedda:Shanghai /Beijing
  • Shuruudaha Lacag-bixinta:L/C,D/A,D/P,T/T,O/A
  • Shuruudaha dhoofinta:Badda/Hawo-qaadis
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    Magaca kiimikada: 10-Deacetylbaccatin III

    Lambarka CAS:

    32981-86-5
    La mid ah:

    10-Desacetylbaccatin III; 10β-Deacetylbaccatin III; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dod ecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca [3,4] benz [1,2-b] oxet-5-hal; 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-hal, 12b-(acetyloxy) -12- (benzoyloxy) -1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-; (Docetaxel USP wasakh);10-Deacetylbaccatin III; 10-Deacetyl baccatin; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-1,2a,3,4,4a,6,9,10,11,12,12a, 12b-Dodecahydro-4,6,9,11,12,12b-hexahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca
    Qaabka molecular: C29H36O10
    Muuqashada: Cad Adag
    Mol. Miisaanka: 544.6
    Kaydinta: 2-8°C Qaboojiyaha

    Qoraal-hoosaad: Dhir-Derived API Intermediate, CAS32981-86-5| GMP Shahaadaysan, COA Waa La Bixiyay

    Waa maxay 10-Deacetylbaccatin III10-DAB)?

    10-Deacetylbaccatin III (C29H36O10) waa diterpenoid bioactive ah oo si dabiici ah looga soo saaro cirbadaha iyo jilifTaksinoocyada (geedaha yew). Iyada oo horudhac muhiim ah u ah nus-ku-samaynta paclitaxel, docetaxel, iyo wakiilada kale ee kiimikaad-ku-salaysan ee taxan-ku-salaysan, 10-DAB waxaa si weyn looga faa'iidaystaa R&D-da dawooyinka iyo soo-saarka daawada oncology.

    Tilmaamaha Muhiimka ah & Tilmaamaha

    • Daahirsanaanta: ≥98% (HPLC-UV waa la ansaxiyay, COA waa la heli karaa)
    • Muuqaal: Caddaan ilaa budo crystalline ah
    • Solubility: Ku milmay methanol, ethanol, DMSO; in yar oo biyo ku milmay
    • Kaydinta: Ku xasili -20°C weelasha hawo-mareenka ah, oo laga ilaaliyo iftiinka
    • Isha dhirta: Si joogto ah ayaa loo goostayTaxus wallichiana(Himalayan yew)

    Codsiyada 10-DAB

    1. Isku-darka Dawooyinka Ka-hortagga Kansarka
      • Dhex dhexaad muhiim u ah wax soo saarka semi-synthetic ee paclitaxel (Taxol®) iyo docetaxel (Taxotere®).
      • Loo isticmaalo R&D soosaarayaasha cusub ee taxanaha ee lagu beegsanayo kansarka u adkaysta daawada.
    2. Cilmi-baarista biochemical
      • Barashada hababka polymerization tubulin iyo kicinta apoptosis.
      • Heerka tixraaca ee kimistariga falanqaynta iyo ilaalinta tayada.
    3. Soo saarista Badeecada Dabiiciga ah
      • Habka soo saarista wax-soo-saarka sare ee waafaqsan mabaadi'da kiimikada cagaaran.

    Maxay tahay sababta 10-DAB nooga timid?

    ✅ Tayada La Xaqiijiyay:

    • Shahaadada Falanqaynta Dufcad-gaar ah (COA) oo wata xogta HPLC, MS, NMR.
    • U hoggaansanaanta tilmaamaha USP, EP, iyo ICH Q7 GMP.

    ✅ Isha Joogta ah:

    • Si anshax leh oo laga soo goostay beeraha Taxus ee la beeray (CITES Lifaaqa II waafaqsan).

    ✅ Global Logistics:

    • U raritaanka silsilad qabow oo aan kala go 'lahayn ee USA, EU, iyo APAC
    • Baakadaha la beddeli karo (1g ilaa 1kg, fijaan dhalada amber leh oo qallajiye leh).

    Taageerada Farsamada & Dukumentiyada

    • MSDS bilaasha ah (Xaashida Xogta Badbaadada Qalabka) iyo xogta xasiloonida marka la codsado.
    • Isku-dubaridka gaarka ah iyo qiimaha badan ee ay heli karaan la-hawlgalayaasha OEM.
    • Taageerada sharciyeynta ee u go'an soo gudbinta IND/NDA.

    Badbaadada & U Hogaansanaanta

    • Lambarka CAS: 32981-86-5
    • Xeerarka halista: Ku xir PPE (gacmo-gashi, muraayado) - aan khatar u ahayn isticmaalka xirfadleyda.
    • Xaaladda Nidaaminta: REACH diiwaangashan; DMF diyaar u ah macaamiisha dawooyinka

    FAQs ee 10-DAB

    S: 10-DAB ma loo isticmaali karaa si toos ah daraasadaha dhaqanka unugga?
    J: Maya. Waxay u baahan tahay wax ka beddel kiimikaad (tusaale, silsilad-side-ku-darka) si ay u noqoto taxaxayaal noole firfircoon.

    S: Waa maxay wakhtiga hogaanka ee dalabaadka 500g?
    A: Waqtiga wax soo saarka caadiga ah: 2-3 toddobaad. Dhoofinta degdega ah waa la heli karaa

    S: Ma bixisaa borotokoolka isku dhafka cashuuraha?
    J: Haa! Warqadaha cad ee farsamada ayaa diyaar u ah macaamiisha u qalma.

    Sharaxaad:
    Isha 98% HPLC-fasalka 10-Deacetylbaccatin III (CAS 32981-86-5) - Soosaar cashuureedka GMP ee loogu talagalay isku-dhafka paclitaxel. Dalabka badan, COA/MSDS, iyo taageerada sharciyeynta ayaa lagu daray.

    1. Erayada furaha
      • Asaasiga ah: "Adeegaha 10-Deacetylbaccatin III", "Nadiifinta Sare 10-DAB", "Paclitaxel precursor"
      • Daba-dheer: "Qiimaha CAS 32981-86-5", "Taxus-ka laga soosaaray cilmi-baarista kansarka", "GMP 10-DAB"
    2. Erayada furaha
      • "Taxane dhexdhexaad ah", "paclitaxel semi-synthetic", "C29H36O10"
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