10-Deacetylbaccatin III (10-DAB)

10-Deacetylbaccatin III (10-DAB) Mufananidzo Unowanikwa
  • 10-Deacetylbaccatin III (10-DAB)

Tsanangudzo Pfupi

10-Deacetylbaccatin III (C29H36O10) inonzi bioactive diterpenoid inotorwa kubva pane tsono nemakwati emuti.Taxusmhando (yew miti). Sechinhu chinotungamira mu semi-synthesis ye paclitaxel, docetaxel, uye mamwe taxane-based chemotherapeutic agents, 10-DAB inoshandiswa zvakanyanya mumishonga R&D uye oncology kugadzirwa kwezvinodhaka.

10-Deacetylbaccatin III, iyo inozivikanwawo se10-DAB kana 10-DAB III, inhengo yakanyatsobatana yakasikwa yakasvibiswa kubva kune tsono dzakaomeswa uye matavi maduku eEuropean yew tree (Taxus baccata) .10-Deacetylbaccatin III inotangira kune anti-cancer drug docetaxel (Taxotere). pacitaxel (taxol); cabazitaxel. 10-10-deacetylbaccatin III yakawanikwa inosarudza kudzivisa kukura kweL. DONOVANI intracellular amastigotes mukati meJ774 murine macrophages in vitro pa nanomolar concentrations ne IC (50) kukosha kwe70 nM.


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    Kemikari zita: 10-Deacetylbaccatin III

    Nhamba yeCAS:

    32981-86-5
    Mashoko anoreva zvakafanana:

    10-Desacetylbaccatin III; 10β-Deacetylbaccatin III; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dod ecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-imwe; 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one, 12b-(acetyloxy) -12-(benzoyloxy) -1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-; (Docetaxel USP Kusachena);10-Deacetylbaccatin III; 10-Deacetyl baccatin; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-1,2a,3,4,4a,6,9,10,11,12,12a, 12b-Dodecahydro-4,6,9,11,12,12b-hexahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-imwe 12b-acetate, 12-acetate (USP-benzo);
    Molecular fomu: C29H36O10
    Chitarisiko: White Solid
    Mol. Kurema 544.6
    Kuchengeta: 2-8°C Firiji

    Subtitle: Plant-Derived API Intermediate, CAS32981-86-5| GMP Yakasimbiswa, COA Yakapiwa

    Chii chinonzi 10-Deacetylbaccatin III (10-DAB)?

    10-Deacetylbaccatin III (C29H36O10) inonzi bioactive diterpenoid inotorwa kubva pane tsono nemakwati emuti.Taxusmhando (yew miti). Sechinhu chinotungamira mu semi-synthesis ye paclitaxel, docetaxel, uye mamwe taxane-based chemotherapeutic agents, 10-DAB inoshandiswa zvakanyanya mumishonga R&D uye oncology kugadzirwa kwezvinodhaka.

    Key Zvinotsanangurwa & Zvimiro

    • Kuchena: ≥98% (HPLC-UV yakasimbiswa, COA iripo)
    • Kuonekwa: Kuchena kusvika kune-white crystalline powder
    • Solubility: Soluble mu methanol, ethanol, DMSO; inonyungudika zvishoma mumvura
    • Kuchengetedza: Yakagadzikana pa -20 ° C mumidziyo isina mhepo, yakachengetedzwa kubva kuchiedza
    • Plant Source: Yakakohwewa zvinogaraTaxus wallichiana(Himalayan yew)

    Zvishandiso zve10-DAB

    1. Anticancer Drug Synthesis
      • Yakakosha yepakati ye semi-synthetic kugadzirwa kwe paclitaxel (Taxol®) uye docetaxel (Taxotere®).
      • Inoshandiswa muR&D yenovel taxane derivatives yakanangana nemishonga isingarapike kenza.
    2. Biochemical Research
      • Kudzidza kwe tubulin polymerization nzira uye apoptosis induction.
      • Reference standard yeanalytical chemistry uye yemhando control.
    3. Natural Product Extraction
      • Yakakwira-goho rekubvisa maitiro inoenderana neyakasvibira chemistry nheyo.

    Sei Kuwana 10-DAB kubva kwatiri?

    ✅ Certified Hunhu:

    • Batch-specific Certificate of Analysis (COA) ine HPLC, MS, NMR data.
    • Inoenderana neUSP, EP, uye ICH Q7 GMP nhungamiro.

    ✅ Sustainable Sourcing:

    • Kukohwewa kubva muminda yakarimwa yeTaxus (CITES Appendix II inowirirana).

    ✅ Global Logistics:

    • Seamless inotonhora-cheni yekutumira kuUSA, EU, uye APAC matunhu.
    • Customizable packaging (1g kusvika 1kg, amber girazi mabhodhoro ane desiccant).

    Tsigiro yehunyanzvi & Zvinyorwa

    • Yemahara MSDS (Material Chengetedzo Dhata Sheet) uye kugadzikana data pakukumbira.
    • Tsika synthesis uye yakawanda mitengo inowanikwa kune OEM vanobatana.
    • Yakatsaurirwa kudzora tsigiro kune IND/NDA kutumira.

    Kuchengetedza & Kutevedzera

    • Nhamba yeCAS: 32981-86-5
    • Hazard Codes: Bata nePPE (magirovhosi, magirovhosi) - isina njodzi pakushandisa nyanzvi.
    • Regulatory Status: REACH yakanyoreswa; DMF inowanikwa kune vatengi vemishonga.

    FAQs ye10-DAB

    Mubvunzo: Inogona here 10-DAB kushandiswa zvakananga mumasero etsika zvidzidzo?
    A: Kwete. Inoda kugadziriswa kwemakemikari (eg, side-chain kuwedzera) kuti ive bioactive taxanes.

    Mubvunzo: Ndeipi nguva yekutungamira ye500g maodha?
    A: Yakajairwa nguva yekugadzira: 2-3 mavhiki. Express shipping iripo.

    Mubvunzo: Iwe unopa taxane synthesis protocol?
    A: Hongu! Mapepa machena ehunyanzvi anowanikwa kune vatengi vanokwanisa.

    Tsanangudzo:
    Kunobva 98% HPLC-giredhi 10-Deacetylbaccatin III (CAS 32981-86-5) - GMP-yakasimbiswa Taxus inotorwa paclitaxel synthesis. Maodha akawanda, COA/MSDS, uye tsigiro yekudzora inosanganisirwa.

    1. Keywords:
      • Chekutanga: "10-Deacetylbaccatin III mutengesi", "High kuchena 10-DAB", "Paclitaxel precursor"
      • Muswe wakareba: "CAS 32981-86-5 mutengo", "Taxus inobvisa yekutsvaga cancer", "GMP 10-DAB"
    2. Keywords:
      • "Taxane yepakati", "semi-synthetic paclitaxel", "C29H36O10", "yew tree compound"
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