| Orukọ kemikali: | 10-Deacetylbaccatin III |
Nọmba CAS: | 32981-86-5 |
| Awọn itumọ ọrọ sisọ: | 10-Desacetylbaccatin III; 10β-Deacetylbaccatin III; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy) -1,2a,3,4,4a,6,9,10,11,12,12a,12b-dod ecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca [3,4] benz [1,2-b] oxet-5-ọkan; 7,11-Methano-5H-cyclodeca [3,4] benz [1,2-b] oxet-5-ọkan, 12b- (acetyloxy) -12- (benzoyloxy) -1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-; (Docetaxel USP aimọ);10-Deacetylbaccatin III; 10-Deacetyl baccatin; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-1,2a,3,4,4a,6,9,10,11,12,12a, 12b-Dodecahydro-4,6,9,11,12,12b-hexahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca [3,4] benz [1,2-b] oxet-5-ọkan 12b-acetate, (USPatete, 12-); |
| Fọọmu molikula: | C29H36O10 |
| Ìfarahàn: | White Ri to |
| Mol. Ìwúwo: | 544.6 |
| Ibi ipamọ: | 2-8 ° C firiji |
Itumọ-akọle: Ohun ọgbin-Ti ariwade API Intermediate, CAS32981-86-5| Ifọwọsi GMP, COA Pese
Kini 10-Deacetylbaccatin III (10-DAB)?
10-Deacetylbaccatin III (C29H36O10) jẹ diterpenoid bioactive ti a yọ jade nipa ti ara lati awọn abere ati epo igi tiTaxiseya (igi yew). Gẹgẹbi iṣaju bọtini kan ninu iṣelọpọ ologbele ti paclitaxel, docetaxel, ati awọn aṣoju chemotherapeutic ti o da lori taori, 10-DAB jẹ lilo pupọ ni R&D elegbogi ati iṣelọpọ oogun oncology.
Awọn pato bọtini & Awọn ẹya ara ẹrọ
- Mimo: ≥98% (HPLC-UV ti a fọwọsi, COA wa)
- Irisi: Funfun si pa-funfun okuta lulú
- Solubility: Soluble ni methanol, ethanol, DMSO; die-die tiotuka ninu omi
- Ibi ipamọ: Idurosinsin ni -20°C ninu awọn apoti airtight, aabo lati ina
- Orisun Ohun ọgbin: Ikore alagberoTaxus wallichiana(Himalayan yew)
Awọn ohun elo ti 10-DAB
- Akopọ Anticancer Oògùn
- Agbedemeji pataki fun iṣelọpọ ologbele-sintetiki ti paclitaxel (Taxol®) ati docetaxel (Taxotere®).
- Ti a lo ninu R&D fun awọn itọsẹ owo-ori aramada ti o fojusi awọn aarun ti ko ni oogun.
- Iwadi biokemika
- Iwadi ti awọn ọna ṣiṣe polymerization tubulin ati ifisi apoptosis.
- Idiwọn itọkasi fun kemistri atupale ati iṣakoso didara.
- Adayeba ọja isediwon
- Ilana isediwon eso-giga ni ibamu pẹlu awọn ilana kemistri alawọ ewe.
Kini idi ti Orisun 10-DAB lati ọdọ Wa?
✅ Didara Ifọwọsi:
- Iwe-ẹri Itupalẹ Batch-pato (COA) pẹlu data HPLC, MS, NMR.
- Ni ibamu pẹlu USP, EP, ati ICH Q7 GMP itọnisọna.
✅ Orisun Alagbero:
- Ikore ti aṣa lati awọn ohun ọgbin Taxus ti a gbin (Ibaramu CITES Afikun II).
✅ Awọn eekaderi agbaye:
- Gbigbe pq tutu ti ko ni ailopin si AMẸRIKA, EU, ati awọn agbegbe APAC.
- Iṣakojọpọ asefara (1g si 1kg, awọn lẹgbẹrun gilasi amber pẹlu desiccant).
Imọ Support & Iwe
- MSDS Ọfẹ (Iwe Data Aabo Ohun elo) ati data iduroṣinṣin lori ibeere.
- Iṣajọpọ aṣa ati idiyele olopobobo wa fun awọn alabaṣiṣẹpọ OEM.
- Atilẹyin ilana igbẹhin fun awọn ifisilẹ IND/NDA.
Aabo & Ibamu
- Nọmba CAS: 32981-86-5
- Awọn koodu eewu: Mu pẹlu PPE (awọn ibọwọ, awọn goggles) - kii ṣe eewu fun lilo alamọdaju.
- Ipo Ilana: REACH forukọsilẹ; DMF wa fun awọn onibara elegbogi.
FAQs fun 10-DAB
Q: Njẹ 10-DAB le ṣee lo taara ni awọn ẹkọ aṣa sẹẹli?
A: Bẹẹkọ. O nilo iyipada kẹmika (fun apẹẹrẹ, afikun ẹwọn ẹgbẹ) lati di awọn taxi bioactive.
Q: Kini akoko asiwaju fun awọn ibere 500g?
A: Standard gbóògì akoko: 2-3 ọsẹ. Kiakia sowo wa.
Q: Ṣe o pese awọn ilana iṣelọpọ ti owo-ori?
A: Bẹẹni! Awọn iwe funfun imọ-ẹrọ wa fun awọn alabara ti o peye.
Apejuwe:
Orisun 98% HPLC-grade 10-Deacetylbaccatin III (CAS 32981-86-5) - GMP-ifọwọsi Taxus jade fun iṣelọpọ paclitaxel. Awọn ibere olopobobo, COA/MSDS, ati atilẹyin ilana pẹlu.
- Awọn ọrọ-ọrọ:
- Alakoko: "Olupese 10-Deacetylbaccatin III", "Mimọ giga 10-DAB", "Paclitaxel ṣaaju"
- Gigun-iru: "owo CAS 32981-86-5", "Taxus jade fun iwadii akàn", "GMP 10-DAB"
- Awọn ọrọ-ọrọ:
- “Agbedemeji Taxane”, “paclitaxel-synthetic ologbele”, “C29H36O10″, “apapo igi yew”
