10-Deacetylbaccatin III (10-DAB)

10-Deacetylbaccatin III (10-DAB) Hoton da aka Fito
  • 10-Deacetylbaccatin III (10-DAB)

Takaitaccen Bayani:

10-Deacetylbaccatin III (C29H36O10) wani diterpenoid ne mai bioactive wanda aka samo ta halitta daga allura da haushi naTaxusnau'in (bishiyoyin yew). A matsayin maɓalli mai mahimmanci a cikin ƙaramin kira na paclitaxel, docetaxel, da sauran magungunan chemotherapeutic na tushen haraji, 10-DAB ana amfani da su sosai a cikin R&D na magunguna da kuma samar da magungunan oncology.

10-Deacetylbaccatin III, wanda kuma aka sani da 10-DAB ko 10-DAB III, wani nau'in kwayoyin halitta ne masu dangantaka da ke da alaƙa da busassun busassun allura da ƙananan rassan bishiyar yew na Turai (Taxus baccata) .10-Deacetylbaccatin III shine precursor ga maganin ciwon daji na docetaxel (Taxotere). pacitaxel (taxol); cabazitaxel. An samo 10-10-deacetylbaccatin III don zaɓin hana haɓakar L. DONOVANI intracellular amastigotes a cikin J774 murine macrophages in vitro a ƙananan ƙwayoyin nanomolar tare da ƙimar IC (50) na 70 nM.


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    Sunan sinadarai: 10-Deacetylbaccatin III

    Lambar CAS:

    32981-86-5
    Makamantuwa:

    10-Desacetylbaccatin III; 10β-Deacetylbaccatin III; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy) -1,2a,3,4,4a,6,9,10,11,12,12a,12b-dod ecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca [3,4] benz [1,2-b] oxet-5-daya; 7,11-Methano-5H-cyclodeca[3,4] benz [1,2-b] oxet-5-daya, 12b- (acetyloxy) -12- (benzoyloxy) -1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-; (Docetaxel USP rashin tsarki);10-Deacetylbaccatin III; 10-Deacetyl baccatin; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS) -1,2a,3,4,4a,6,9,10,11,12,12a, 12b-Dodecahydro-4,6,9,11,12,12b-hexahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca [3,4] benz [1,2-b] oxet-5-daya 12b-acetate, 12-benzo;
    Sifar kwayoyin halitta: Saukewa: C29H36O10
    Bayyanar: Farin Tauri
    Mol. Nauyi: 544.6
    Ajiya: 2-8°C Firiji

    Subtitle: Matsakaicin API Daga Shuka-Tsaro, CAS32981-86-5| Tabbataccen GMP, An Samar da COA

    Menene 10-Deacetylbaccatin III10-DAB)?

    10-Deacetylbaccatin III (C29H36O10) wani diterpenoid ne mai bioactive wanda aka samo ta halitta daga allura da haushi naTaxusnau'in (bishiyoyin yew). A matsayin maɓalli mai mahimmanci a cikin ƙaramin kira na paclitaxel, docetaxel, da sauran magungunan chemotherapeutic na tushen haraji, 10-DAB ana amfani da su sosai a cikin R&D na magunguna da kuma samar da magungunan oncology.

    Mabuɗin Bayani & Fasaloli

    • Tsafta: ≥98% (HPLC-UV ingantacce, COA akwai)
    • Bayyanar: Fari zuwa kashe-fari crystalline foda
    • Solubility: Mai narkewa a cikin methanol, ethanol, DMSO; dan kadan mai narkewa cikin ruwa
    • Ajiye: Barga a -20 ° C a cikin kwantena na iska, an kare shi daga haske
    • Tushen Shuka: Ci gaba da girbiTaxus wallichiana(Himalayan ya)

    Aikace-aikace na 10-DAB

    1. Maganin Maganin Ciwon Kankara
      • Matsakaicin matsakaici don samar da Semi-synthetic na paclitaxel (Taxol®) da docetaxel (Taxotere®).
      • An yi amfani da shi a cikin R&D don abubuwan da suka samo asali na harajin da ke niyya da cututtukan daji masu jure wa ƙwayoyi.
    2. Binciken Biochemical
      • Nazarin hanyoyin tubulin polymerization da shigar da apoptosis.
      • Ma'aunin tunani don nazarin sunadarai da sarrafa inganci.
    3. Haɓaka Samfurin Halitta
      • Tsarin hakar babban amfanin gona mai dacewa da ka'idodin sunadarai kore.

    Me yasa Tushen 10-DAB daga gare Mu?

    ✅ Tabbataccen inganci:

    • Takamaiman Takaddun Takaddun Takaddun Takaddun Bincike (COA) tare da bayanan HPLC, MS, NMR.
    • Mai yarda da jagororin USP, EP, da ICH Q7 GMP.

    ✅ Mahimmanci mai dorewa:

    • An girbe bisa ɗabi'a daga gonakin Taxus da aka noma (CITES Karin Bayani na II).

    ✅ Global Logistics:

    • Jigilar sarkar sanyi mara kyau zuwa yankunan Amurka, EU, da APAC.
    • Marufi na musamman (1g zuwa 1kg, gilashin gilashin amber tare da desiccant).

    Taimakon Fasaha & Takardu

    • MSDS kyauta (Sheet ɗin Tsaro na Kayan aiki) da bayanan kwanciyar hankali akan buƙata.
    • Haɗin kai na al'ada da farashi mai yawa akwai don abokan haɗin OEM.
    • Tallafin ƙa'ida na sadaukarwa don ƙaddamar da IND/NDA.

    Tsaro & Biyayya

    • Lambar CAS: 32981-86-5
    • Lambobin haɗari: Sarrafa tare da PPE (safofin hannu, tabarau) - mara haɗari don amfanin ƙwararru.
    • Matsayin Gudanarwa: REACH rajista; DMF akwai don abokan cinikin magunguna.

    FAQs na 10-DAB

    Tambaya: Za a iya amfani da 10-DAB kai tsaye a cikin nazarin al'adun tantanin halitta?
    A: A'a. Yana buƙatar gyare-gyaren sinadarai (misali, ƙarin sarkar gefe) don zama harajin bioactive.

    Tambaya: Menene lokacin jagora don odar 500g?
    A: Daidaitaccen lokacin samarwa: 2-3 makonni. Akwai jigilar kayayyaki da sauri.

    Tambaya: Kuna samar da ka'idojin tattara haraji?
    A: iya! Akwai farar takarda na fasaha don ƙwararrun abokan ciniki.

    Bayani:
    Source 98% HPLC-grade 10-Deacetylbaccatin III (CAS 32981-86-5) - GMP-kwararren Taxus tsantsa don haɗin paclitaxel. Babban umarni, COA/MSDS, da goyan bayan tsari sun haɗa.

    1. Mahimman kalmomi:
      • Na farko: "10-Deacetylbaccatin III mai ba da kaya", "High tsarki 10-DAB", "Paclitaxel precursor"
      • Dogon wutsiya: "Farashin CAS 32981-86-5", "Tsarin Taxus don binciken ciwon daji", "GMP 10-DAB"
    2. Mahimman kalmomi:
      • "Taxane matsakaici", "Semi-synthetic paclitaxel", "C29H36O10", "Yew itace fili"
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