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| Product name: | Urolithin A bulk powder |
| Synonyms | 3,8-Dihydroxybenzo[c]chromen-6-one; Uro-A; UROA; Pomegranate Extract Powder;3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one; 3,8-dihydroxybenzo[c] chromen-6-one |
| Molecular Formula | C13H8O4 |
| Molecular Weight | 228.20 |
| CAS number | 1143-70-0 |
| Specifications | 99% |
| Appearance/color | Beige to Yellow powder |
| Solubility | slightly soluble in ethanol, and hardly soluble in water |
| Benefits | Anti-aging, improve muscular strength |
| Application | sports nutrition, dietary supplements, cosmetic |
Urolithin A Food Sources
According to Wikipedia, Urolithin A is not known to be found in any dietary food source at present. However, you are able to get endogenously Urolithin A by digesting ellagitannins and ellagic acid-rich foods, which are dietary polyphenols found in various fruits and berries, nuts, muscadine grapes, oak-aged wines and spirits, such as pomegranates, blackberries, camu-camu, strawberries, raspberries, walnuts, hazelnuts, acorns, chestnuts, and pecans, etc.
Urolithin A Benefits
Human clinical trials show that Urolithin A supplementation is especially beneficial to anti-aging and muscular strength improvement. It may slow down a part of the aging process that’s related to the creation of energy within our cells.
Muscle wellness undergoes a natural drop when you are 30+. Skeletal muscle mass declines along with a reduction in strength. Urolithin A enhances adrenal and muscular function, supplying more energy. It’s a naturally-occurring anti-aging chemical that may benefit anyone seeking to maintain muscle health.
500mg Urolithin A was proven to cause gene expression linked to mitochondrial metabolism and function and boost the potency of the hamstring leg muscle in steps of knee extension and flexion in obese 40 to 65-year-olds. Information from two randomized double-blind human clinical trials.
Urolithin A Safety
Urolithin A is approved by the European Union as a novel food ingredient.
The US Food and Drug Administration (FDA) in 2018 has granted urolithin A its GRAS status used in dietary supplement formula. GRAS means that Urolithin A is generally regarded as safe with a dosage of 500mg to 1 gram per serving.
Urolithin A safety was researched at a series of preclinical and clinical trials, which encourage its health safety for its intended uses. Repeated dosage 28-day and 90-day studies of urolithin A in rats didn’t demonstrate any toxicological impact in some of the parameters measured in any way doses tested.
Supplementation for up to 90 days with urolithin A didn’t lead to any signs of neurological or reproductive toxicities in improved screening periods of repeated-dose studies such as evaluation of spermatogenesis or oestrus cycles, ophthalmoscopic examinations, operational observatory battery display, and motor activity assessments.
Urolithin A clinical trials
A clinical trial in healthy 40 to 65 years old participants revealed that 4 months of daily supplementation of 500mg ultra-pure Urolithin A 99% resulted in substantial progress in leg muscle strength.
A randomized clinical trial conducted in 18-80 years old wholesome adults in the United States made a comparison of Urolithin A levels following supplementation of Urolithin A and pomegranate juice. It revealed that 500mg of Urolithin A delivers larger than 6X greater Urolithin compared to 8oz (240ml) of 100 percent pomegranate juice.
Urolithin A supplements Available
The first nutritional supplement products containing Urolithin A launched in July 2020 under the brand name of Timeline Cellular Nutrition, or Timeline Nutrition for short.
