According to Wikipedia, the IUPAC name of piperlongumine is 1-[(2E)-3-(3,4,5-Trimethoxyphenyl)prop-2-enoyl]-5,6-dihydropyridin-2(1H)-one, and some websites prefer to use 5,6-dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(1H)-pyridinone.
The full chemical name of piperlongumine is so long and no people can remember, so researchers use piplartine or piperlongumine in most of the scientific documents. And 20069-09-4 is its CAS registered number.
Product name: Piperlongumine powder
Other Name:Piplartin, Piperlongumine extract, Piplartine, 5,6-Dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-2(1H)-pyridinone,PPLGM, pippali powder, Piper Longum extract
Botanical Source:Piper Longum Linn
Free Sample :Available
Appearance: White crystalline powder
Shelf Life: 2 years
Piperlongumine is mainly found in Piper longum, a plant belonging to South Asian origin. India and China are the two main countries that sell commercial Piper longum powders and supplements on Amazon and other e-commerce websites.
Piper longum is commonly known as long pepper or pippali in India. Piper longum contains alkaloids, amides, Lignans, Esters, volatile oils, etc.
The Piper longum fruit has been used in the Ayurvedic system of medicine and Traditional Chinese Medicines for a very long time.
There is no bulk piperlongumine powder on the market yet. Most of the suppliers are reagent companies, and their products are for research use only. In addition, their quantity is usually only 10mg to 500mg in a very small bottle.
There are ratio extracts of piper longum plant, with popular specifications such as 4:1, 10:1, 20:1, etc.
Indian herbal products containing piperlongumine are mainly ratio extract. How many piperlongumines are in it? Nobody knows. Only standardized piperlongumine from piper longumine can be measured.
Cima’s specification is 98% min.
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Piperlongumine is not soluble in water. So if you want to make full use of piperlongumine supplements, you need to make piperlongumine in the forms of capsules instead of piperlongumine tablets or powders.
Piperlongumine is soluble in organic solvents such as ethanol, DMSO, and dimethylformamide (DMF).
Mechanism of Action of Piperlongumine
Benefits of Piperlongumine
As a traditional medicine used in China and India, piper longum plant is reported to be a respiratory tonic, and good for healthy digestion and immune system.
For piperlongumine itself, anti-cancer and anti-aging are the two main concerns.
Piperlongumine for anti-aging (senolytic)
Piperlongumine is a novel senolytic agent. If you want to know how piperlongumine works for anti-aging, you need to know senescent cells first.
Senescent cells play a vital role in many age‐associated diseases. We can say that senescent cells are the root cause of aging.
Then how to solve these diseases? The easiest way is to kill these senescent cells! Senescent cells are fat dysfunctional cells that accumulate with age in all tissues and organs of your body. Piperlongumine induces apoptosis in senescent cells and kills them through a ROS-independent mechanism.
Piperlongumine is able to slow down senescent cells’ formation, selectively destory senescent cells and revitalize your health. It works well with other anti-aging ingredients, such as pterostilbene, resveratrol, fisetin, etc.
piperlongumine clinical trials
Piperlongumine has been extensively studied in cancer treatment going up on clinical trials. Since the first report related to its use on cancer research (in 2011) around 80 papers have been published in less than 10 years, but a gap still remains. There are no metabolism studies of piperlongumine in the human organism.
Piperlongumine side effects
No adverse effects are reported yet.