Oleoylethanolamide(OEA)

Khoom npe:  Oleoylethanolamide , N-Oleoylethanolamide , OEA
Lwm yam lub npe:  N- (2-Hydroxyethyl) -9-Z-octadecenamide, N-oleoyl ethanolamide, Oleoyl monoethanolamide, 9-Octadecenamide, N- (2-Hydroxyethyl) oleamide
CAS Tsis:  111-58-0
Molecular formular:  C ₂₀H ₃₉TSIS MUAJ ₂
Molecular Nyhav: 325,5
tshuaj ntsuam: 90%, 95%, 85% min
Tsos: mis dawb hmoov

Oleoylethanolamide yog ib yam dab tsi tshiab rau lub zaub mov ua lag luam raws li ib tug nrov kev noj haus ntxiv muaj siv nyob rau hauv poob qauv. Muaj ntau bodybuilding kiv cua tham txog oleoylethanolamide rau reddit thiab lwm yam social networking platforms.

Oleoylethanolamide yog ib tug natural metabolite ntawm oleic acid ua nyob rau hauv cov hnyuv nyob rau hauv lub cev tib neeg. Nws yog lawm occuring, thiab cov kws txawj hu rau nws "endogenous".

OEA yog ib tug natural regulator qab los noj mov, qhov hnyav thiab roj uas txhaws taus. Nws yog ib tug natural metabolite uas yog nyob rau hauv me me nyob rau hauv koj cov hnyuv. OEA yuav pab tswj kev tshaib kev nqhis, qhov hnyav, lub cev muaj roj thiab roj uas txhaws taus los ntawm losis tswvyim dabtsi rau ib tug receptor lub npe hu ua PPAR-Alpha (Peroxisome proliferator-tshuab txais receptor alpha). Nyob rau hauv essence, OEA tsub kom cov metabolism hauv lub cev muaj roj thiab qhia koj lub paj hlwb uas koj yog tag nrho thiab nws yog lub sij hawm kom tsis txhob noj. OEA tseem paub mus nce uas tsis yog-ce muaj feem calorie expenditure.

Oleylethanolamide History

Oleoylethanolamide tus lom zog nyob sab li thaum ntxov raws li 50 xyoos dhau los. Ua ntej xyoo 2001, muaj tsis ntau cov kev tshawb fawb nyob rau hauv OEA. Txawm li cas los, hais tias xyoo, Spanish soj ntsuam tsoo down lub lipid thiab kawm yuav ua li cas nws yog ua, qhov twg nws yog siv li cas thiab nws puas zoo li cas. Lawv soj ntsuam kuaj cov nyhuv ntawm OEA rau lub paj hlwb (ntawm nas) los ntawm txhaj nws ncaj qha mus rau hauv lub hlwb ventricles. Lawv nyob tsis muaj ntxim rau cov zaub mov zoo thiab paub tseeb hais tias hais tias OEA tsis ua nyob rau hauv lub hlwb, tab sis, theej, nws ua ib tug nyias muaj nyias ib lub teeb liab uas muaj feem xyuam rau kev tshaib kev nqhis thiab noj mov tus cwj pwm.

Oleylethanolamide VS cannabinoid anandamide

Cov teebmeem ntawm OEA twb xub kawm vim hais tias nws txoj zoo sib xws nrog lwm cov tshuaj, ib tug cannabinoid lub npe hu ua anandamide. Cannabinoids yog hais txog cov nroj tsuag Cannabis, thiab anandamides tam sim no nyob rau hauv cov nroj tsuag (thiab cov yeeb tshuaj xas) yuav ua rau kom ib tug neeg tus ntshaw kom khoom noj txom ncauj los ntawm triggering ib tug noj teb. Raws li Wikipedia, Oleoylethanolamide yog lub monounsaturated analogue ntawm lub endocannabinoid anandamide. Txawm tias OEA muaj ib tug tshuaj qauv uas yog zoo xws li cov anandamide, nws cov teebmeem zaub mov noj thiab ceeb thawj tswj yog cov sib txawv. Tsis zoo li anandamide, OEA ua ntawm nws tus kheej ntawm lub cannabinoid pathway, regulating PPAR-α kev ua si mus tsim kho lipolysis.

Structures of various fatty-acid ethanolamides: oleoylethanolamide (OEA), palmitoylethanolamide (PEA) and anandamide (arachidonoylethanolamide, AEA). (Cima Science Co., Ltd is the only manufacturer of bulk raw materials of OEA, PEA and AEA in China, if you need sample and price quote, please drop us an email in the contact us page.)

OEA uake uas muaj affinity rau lub peroxisome-proliferator-tshuab txais receptor-ib (PPAR-a), ib tug nuclear receptor uas regulates ob peb yam ntawm lipid metabolism.

Ntuj qhov chaw ntawm oleoylethanolamide

Oleoylethanolamide yog ib tug natural metabolite ntawm oleic acid. Yog li ntawd, cov zaub mov containg oleic acid yog ib tug ncaj qhov chaw ntawm OEA.

Oleic acid yog thawj rog nyob rau hauv zaub roj xws li txiv roj, canola thiab sunflower. Oleic acid kuj muaj nyob rau hauv cov noob txiv roj, nqaij, nqaij qaib, cheese, thiab lwm yam

Kev noj haus qhov chaw nplua nuj nyob rau hauv oleic acid muaj xws li: canola roj, txiv roj roj, Avocado Roj, Almond roj, Avocados, High Oleic Safflower roj

Ib txhia cov lus tseeb hais txog Oleic Acid:

Ib qho ntawm feem ntau cov rog hauv tib neeg lub mis mis nyuj

Ua li 25% ntawm rog nyob rau hauv nyuj cov kua mis

monounsaturated

Omega-9 fatty acid

Tshuaj mis yog C18H34O2 (CAS 112-80-1)

Hangs tawm nrog triglycerides

Yog siv nyob rau hauv siab luv nqi tshuaj pleev ib ce raws li ib tug heev zoo moisturizer

Pom nyob rau hauv cov mis nyuj muaj roj, cheese, txiv roj roj, grapeseed roj, ceev, avocados, qe thiab nqaij

Tej zaum yuav lub luag hauj lwm rau feem ntau ntawm cov kev pab kho mob ntawm txiv roj roj!

Cov ntaub ntawv super hero ceg nrog rau lwm cov mis nyuj proteins uas kom sib ntaus sib tua cancer hlwb

Oleoylethanolamide pab cuam

Oleoylethanolamide (OEA) yog zoo kom poob ceeb thawj raws li qab los noj mov regulator thiab txhawb kev noj qab nyob cov roj ntau ntau nyob rau hauv cov neeg laus.

OEA li qab los noj mov suppressant

Kev qab los yog hluav yog ib tug loj tswj taw tes rau lub zog (khoom noj khoom haus) kom tsawg, tswj qab los noj mov yog qhov tseem ceeb heev nyob rau hauv kev tswj kev noj qab lub cev hnyav. Yuav ua li cas puas OEA controlyour qab los noj mov? Tej zaum koj yuav saib lub mechanism ntawm kev ua hauv qab no.

OEA thiab roj uas txhaws taus

Txiv roj roj yog ib tug noj haus superstar, thiab yuav pab qis "phem" LDL roj uas txhaws taus thiab ua rau kom "zoo" HDL. Yog vim li cas? Mus txog 85% ntawm txiv roj roj yog oleic acid, thiab lub ntsiab noj qab nyob zoo metabolite ntawm oleic acid yog OEA (Oleoylethanolamide yog tag nrho lub npe). Yog li ntawd, muaj yog tsis muaj cov tsis ntseeg tias OEA pab healty cholesterol.

Ib txhia rereearch qhia tau hais tias oleoylethanolamide muaj zoo los ntawm kev ntxhov siab vim, thiab ntau txoj kab thiab pov thawj uas yuav tsum tau mus txhawb.

Manufacutring txheej txheem ntawm Oleoylethanolamide

The flow char of Oleoylethanolamide is below:

Genral kauj ruam yog: reactiong → Purification txheej txheem → Pom → Re-yaj nyob rau hauv ethanol → hydrogenation → filtrate Clear Kua → crystallization → Pom → Xeem → Packing → End khoom

Mechanism ntawm kev txiav txim ntawm oleoylethanolamide

Yuav kom muab tso nws tsuas, oleoylethanolamide ua hauj lwm raws li ib tug kev tshaib kev nqhis regulator. OEA yog muaj peev xwm tswj koj cov zaub mov kom tsawg los ntawm kev qhia lub hlwb uas lub cev yog tag nrho, thiab tsis muaj ntau cov khoom noj uas yuav tsum tau. Koj noj tsawg txhua txhua hnub, thiab koj lub cev tej zaum yuav tsis nyhav dhau heev lawm nyob rau hauv lub ntev mus dhia.

Cov anti-rog kev ua ntawm oleoylethanolamide (OEA) yog raws li qhia hauv daim duab. OEA yog tsim thiab mobilized nyob rau hauv lub proximal hnyuv los ntawm noj cov zaub mov-derived oleic acid, xws li txiv roj roj. High-roj noj cov zaub mov yuav inhibit OEA ntau lawm nyob rau hauv cov hnyuv. OEA thiaj li noj kom tsawg los activating homeostatic oxytocin thiab histamine hlwb circuitry raws li hedonic dopamine txoj. Muaj pov thawj hais tias OEA kuj attenuate hedonic cannabinoid receptor 1 (CB1R) signaling, qhov ua kom cov uas yog txuam nrog nce cov zaub mov kom tsawg. OEA thiaj lipid thauj mus rau hauv adipocytes kom txo tau cov roj loj. Ntxiv elucidation txog cov teebmeem ntawm OEA rau cov zaub mov kom tsawg thiab lipid metabolism yuav pab nyob rau hauv qhov kev txiav txim ntawm muaj sia mechanisms uas yuav tsom rau tsim ntau zoo rog kev kho mob.

OEA ua hauj lwm mus qhib ib yam dab tsi hu ua PPAR thiab ib txhij du li roj-burning thiab txo rog cia. Thaum twg koj noj, OEA theem nce thiab koj qab los noj mov txo thaum lub piav thoob hlo qab haus huv uas txuas tau mus rau koj lub paj hlwb qhia rau nws tias koj nyob nraum tag nrho. PPAR-α yog ib pab pawg neeg ntawm ligand-tshuab txais nuclear receptor uas muab kev koom tes nyob rau hauv lub noob hais tawm ntawm lipid metabolism thiab energyhomeostasis txoj.

OEA qhia tau hais tias tag nrho cov defining yam ntxwv ntawm ib tug satiety tau:

(1) Nws cheeb pub los ntawm tom lub caij nyoog mus tom ntej no noj mov;

(2) Nws synthesis yog tswj los ntawm as txaus thiab

(3) Nws cov theem yauv circadian hloov mus hloov los.

Oleoylethanolamide phiv

Oleoylethanolamide kev nyab xeeb yog ib tug loj kev txhawj xeeb nrog ntxiv hom neeg uas xav mus sim no tshiab muaj nyob rau hauv lawv cov luj poob qauv.

Tom qab kev rov xyuas dua ntawm tag nrho cov muaj nyob rau ntaub ntawv thiab cov ntaub ntawv, lub US Food thiab Drug Administration (FDA) tau tsis muaj kev txhawj xeeb txog OEA txoj kev nyab xeeb. RiduZone yog thawj branded oleoylethanolamide hmoov muaj txij li thaum 2015.

Oleoylethanolamide yog ib tug metabolite ntawm oleic acid, uas yog ib feem ntawm ib tug noj qab nyob zoo txhua hnub khoom noj. Nws yog muaj kev ruaj ntseg mus sim OEA tshuaj, thiab tsis muaj mob loj los tau qhia.

los tau qhia.

Oleoylethanolamide tib neeg tej kev txom nyem

Nyob rau hauv ib txoj kev tshawb, tsib caug (n = 50) tib neeg kawm xav nyob rau hauv poob phaus tau kom koj noj OEA 2-3 lub sij hawm / hnub, 15-30 feeb ua ntej ib pluag mov rau 4-12 lub lis piam. Kawm muaj cov neeg uas twb tsis siv poob khoom ua ntej, cov neeg uas tej kev phiv cov txheej xwm uas lwm poob phaus khoom, cov neeg uas nws poob plateaued rau lwm poob agents xws li phentermine, cov neeg sim siv lub neej style kev hloov (feem tswj thiab kev qoj ib ce ), thiab cov neeg koom tau tswj rau kev kho mob tej yam kev mob xws li tsis hnov ​​zib kam rau ua, dyslipidemia, tawg thiab kab mob plawv.

Nyob rau hauv ib tug thib ob txoj kev tshawb no, 4 yam kev kawm uas muaj hauv paus tes taw hnyav li ntawm 229, 242, 375 thiab 193 lbs feem, twb qhia coj tus Oleoylethanolamide tsiav tshuaj (ib cov tshuaj ntsiav uas muaj 200mg 90% OEA). Kawm coj 4 tsiav tshuaj (1 capsule 15-30 feeb ua ntej noj mov thiab lawv yuav tsum coj ib tug ntxiv capsule ua ntej lawv coob noj mov ntawm lub hnub) txhua hnub rau 28 hnub. Qhov kawg raug tau yav tas los undergone ncej puab band kev tso kawm. Kawm twb qhia yuav ua rau tsis muaj kev hloov mus rau lawv kev noj haus thiab kev qoj ib ce.

tau

Nyob rau hauv thawj txoj kev tshawb no, kawm poob ib tug nruab nrab ntawm 1-2 lbs / lub lim tiam. Muaj tsis muaj kev phiv tsuas yog rau ib tus neeg mob muaj nraum xeev siab uas tau daws nyob rau hauv tsawg tshaj li ib lub lim tiam. Nyob rau hauv lub thib ob txoj kev tshawb no, 3 tawm ntawm 4 yam kev kawm qhia poob (3, 7, 15 thiab 0 lbs ntsig txog). Tag nrho 4 yam kev kawm qhia txog ib tug 10-15% txo nyob rau hauv feem me me, heev inter-noj mov cov Team sib, thiab tsis muaj kev phiv.

Yog hais tias koj xav nyob rau hauv ntau cov ntaub ntawv ntawm tib neeg raug nrog OEA, thov mus xyuas lub downloadable PDF mus.

Oleoylethanolamide ntau npaum

Muaj tsawg kev tshawb fawb ntaub ntawv tam sim no OEA supplementation nyob rau hauv tib neeg, thiab thaum ntshai li muaj kev nyab xeeb, muaj yog tsis muaj pom zoo npaum li cas. Txawm li cas los, muaj ib co tshuaj nyob rau hauv kev ua lag luam, thiab tej zaum koj yuav nrhiav tau ib co rau koj siv.

Lub dosing ib hnub twg ntawm RiduZone (branded OEA / Oleoylethanolamide 90%) yog 200mg (1capsule nrog tsuas OEA nyob rau hauv nws). Yog hais tias zoo ua ke nrog rau lwm cov khoom xyaw poob, txhua hnub dosing nkawd yuav tsawg, hais 100mg los yog 150mg. Somesupplements

Nws yog pom zoo kom noj oleoylethanolamide tshuaj 30 feeb ua ntej noj tshais thiab noj hmo, koj yuav hnov ​​ntau tag nrho thaum lub sij hawm noj mov thiab raws li ib tug tshwm sim tej zaum yuav noj tsawg.

Kev tshawb fawb cov ntaub ntawv nyob rau hauv oleoylethanolamide

Oleoylethanolamide: ib tug tshiab neeg uas ua ntawv nyob rau hauv lub zog metabolism hauv kev tswj. Lub luag hauj lwm nyob rau hauv cov zaub mov kom tsawg

Oleoylethanolamide tsub kom cov kev qhia ntawm PPAR-Α thiab thiaj li qab los noj mov thiab lub cev hnyav nyob rau hauv rog neeg: Ib tug soj ntsuam mus sib hais

Lub hlwb Molecules thiab qab: Lub Case ntawm Oleoylethanolamide

Oleylethanolamide regulates noj thiab lub cev hnyav los ntawm ua kom ntawm lub nuclear receptor PPAR-ib

Kom ntawm TRPV1 los ntawm cov satiety Factor Oleoylethanolamide

Cai ntawm khoom noj khoom haus kom tsawg los ntawm oleoylethanolamide

Mechanism ntawm oleoylethanolamide rau fatty acid uptake nyob rau hauv me me hnyuv tom qab noj kom tsawg thiab lub cev kom yuag

Oleoylethanolamide: Lub luag hauj lwm ntawm ib tug bioactive lipid amidein modulating noj coj tus cwj pwm

Oleoylethanolamide: A roj pab pawg phooj ywg nyob rau hauv sib ntaus tawm tsam rog

Oleoylethanolamide: A Tshiab Tej zaum Pharmacological Lwm rau cannabinoid Antagonists rau lub Control ntawm qab los