Khoom npe: Pyrroloquinoline Quinone Disodium ntsev
CAS Nr .: 122628-50-6 / 72909-34-3
Molecular Luj: 374.17 / 330.21
Cov roj formula: C14H4N2Na2O8 / C14H6N2O8
Specification: PQQ Disodium ntsev 99%; PQQ Acid 99%
Cov tsos mob: Reddish txiv kab ntxwv rau Reddish Brown Fine Powder.
Daim ntawv thov: dav siv rau kev noj haus ntxiv thiab nutraceuticals.
Cia: Khaws rau hauv qhov chaw so thiab qhuav, kom deb ntawm lub hnub ncaj qha.
Pyrroloquinoline Quinone cov khoom noj
PQQ ib txwm muaj nyob rau hauv feem ntau cov zaub mov, txiv hmab txiv ntoo, thiab zaub (txog), thiab cov qib siab ntawm PQQ tuaj yeem kuaj pom hauv cov khoom noj taum pauv, xws li kiwifruit, lychee, taum ntsuab, taum pauv, rapeseed, mustard, tshuaj yej ntsuab (camellia), ntsuab kua txob, spinach, thiab lwm yam.
G.Haug pom tias nws yog tus thib peb redox cofactor hauv cov kab mob tom qab nicotinamide thiab flavin (txawm tias nws xav tias nws yog naphthoquinone). Anthony thiab Zatman kuj pom tsis paub redox cofactors hauv ethanol dehydrogenase. Xyoo 1979, Salisbury thiab nws cov npoj yaig nrog rau Duine thiab lawv cov npoj yaig tau rho tawm lub hauv paus pseudo los ntawm methanol dehydrogenase ntawm dinoflagellates thiab txheeb xyuas nws cov qauv molecular. Adachi thiab nws cov npoj yaig pom tias Acetobacteria kuj muaj PQQ.
Mechanism ntawm kev txiav txim ntawm Pyrroloquinoline Quinone
Pyrroloquinoline quinone (PQQ) yog ib qho me me quinone molecule, uas muaj cov nyhuv redox, tuaj yeem txo oxidant (antioxidant); Tom qab ntawd nws rov qab los rau hauv daim ntawv nquag los ntawm glutathione. Nws zoo nkaus li ruaj khov vim tias nws tuaj yeem dhau mus ntau txhiab lub voj voog ua ntej depletion, thiab nws yog qhov tshiab vim tias nws muaj feem xyuam rau cov qauv protein ntawm cov hlwb (qee cov tshuaj tiv thaiv kab mob, cov carotenoids tseem ceeb xws li beta-carotene thiab astaxanthin, nyob rau hauv cov cheeb tsam tshwj xeeb ntawm cov hlwb, qhov chaw uas lawv ua si ntau dua antioxidants proportionally). Vim tias qhov sib thooj, PQQ zoo li ua lub luag haujlwm ze ntawm cov proteins xws li carotenoids ntawm cell membranes.
Cov kev ua haujlwm redox no tuaj yeem hloov pauv cov haujlwm protein thiab cov teeb liab hloov txoj hauv kev. Txawm hais tias muaj ntau qhov kev kawm tau zoo hauv vitro (sab nraum cov qauv nyob), qee qhov kev cia siab ntawm PQQ supplementation yog feem ntau cuam tshuam txog kev hloov pauv qee qhov kev hloov pauv cov teeb liab lossis lawv cov txiaj ntsig rau mitochondria. (Ua ntau thiab txhim kho efficiency).
Nws yog coenzyme hauv cov kab mob (yog li rau cov kab mob, nws zoo li B-vitamins), tab sis nws tsis zoo li txuas mus rau tib neeg. Txij li qhov no tsis siv rau tib neeg, ib tsab xov xwm xyoo 2003 hauv Nature, ib phau ntawv xov xwm tshawb fawb, sib cav tias lub tswv yim tias PQ yog cov vitamin compound yog qhov qub thiab qhov zoo tshaj plaws suav tias yog "vitamin zoo li tshuaj."
Tej zaum qhov tseem ceeb tshaj plaws yog cov nyhuv ntawm PQQ ntawm mitochondria, uas muab lub zog (ATP) thiab tswj cov cell metabolism. Cov kws tshawb fawb tau tshawb pom qhov cuam tshuam ntawm PPQ ntawm mitochondria thiab pom tias PQQ tuaj yeem ua rau muaj pes tsawg tus mitochondria thiab tseem txhim kho kev ua haujlwm ntawm mitochondria. Qhov no yog qhov laj thawj tseem ceeb vim li cas PPQ thiaj li muaj txiaj ntsig. Cov enzymes uas muaj PQQ yog lub npe hu ua qabzib dehydrogenase, quinoa protein uas yog siv los ua cov piam thaj sensor.
Cov txiaj ntsig ntawm Pyrroloquinoline Quinone
Muaj mitochondria ntawm lawv qhov zoo tshaj plaws yog qhov tseem ceeb heev rau lub neej noj qab haus huv uas koj tuaj yeem ntsib ntau yam txiaj ntsig thaum noj ppq. Nov yog qee qhov tseem ceeb tshaj plaws txog cov txiaj ntsig pyrroloquinoline quinone.
Txhawb Cell Zog
Vim tias mitochondria tsim lub zog rau cov hlwb, thiab PQQ pab mitochondria ua haujlwm tau zoo, lub zog hauv hlwb nce tag nrho; Qhov no yog Pyrroloquinoline Quinone mitochondrial mechanism. Lub zog ntawm tes tsis siv yog hloov mus rau lwm qhov ntawm lub cev. Yog tias koj lub cev tsis muaj zog txhua hnub, lossis koj xav tias nkees lossis tsaug zog, ces lub zog ntawm PPQ yog qhov tseem ceeb rau koj. Ib txoj kev tshawb nrhiav pom tias tom qab noj PQQ, cov neeg mob uas tau tshaj tawm cov teeb meem ntawm lub zog muaj zog txo qis qis. Yog tias koj tab tom nrhiav ib yam dab tsi los txhawb koj lub zog, PQQ yuav pab tau qhov ntawd.
Tiv thaiv kev paub tsis meej
Nrog rau txoj kev loj hlob ntawm kev tshawb fawb, cov kws tshawb fawb tau pom tias cov paj hlwb loj hlob (NGF) tuaj yeem loj hlob thiab rov zoo. Nyob rau tib lub sijhawm, PQQ tau pom tias muaj txiaj ntsig zoo rau NGF thiab ua kom cov hlab ntsha loj hlob los ntawm 40 npaug. NGF yog qhov tseem ceeb rau kev tsim thiab kev saib xyuas ntawm cov neurons tshiab, thiab nws tuaj yeem kho cov neurons puas tuaj yeem cuam tshuam kev paub txog kev ua haujlwm. Neurons yog cov hlwb uas xa cov ntaub ntawv, yog li peb lub hlwb tuaj yeem sib txuas lus ntawm lawv tus kheej thiab lwm qhov hauv lub cev. Txhim kho qhov zoo thiab ntau ntawm cov neurons tuaj yeem txhim kho kev paub. Yog li ntawd, PQQ muaj kev txhim kho luv luv.
Txhawb kev mob plawv
Pyrroloquinoline quinine muab antioxidant thiab mitochondrial kev txhawb nqa. Cov kev tshawb fawb tau pom tias ob qho tib si PQQ thiab CoQ10 txhawb nqa kev ua haujlwm myocardial thiab siv cov pa oxygen cellular zoo. Pyrroloquinoline quinone tiv thaiv oxidative kev nyuaj siab los ntawm nws rejuvenation.
Pyrroloquinoline Quinone Disodium Salt (PQQ): Cov txiaj ntsig, Siv, thiab Phau Ntawv Qhia Kev Nyab Xeeb
Taw qhia
Pyrroloquinoline Quinone Disodium Salt (PQQ) yog ib qho ruaj khov, dej-soluble daim ntawv ntawm PQQ, redox cofactor nrog muaj zog antioxidant zog. Pom muaj nyob hauv cov kab hauv cov khoom noj xws li kiwifruit, parsley, thiab kua txob ntsuab, PQQ tau siv dav hauv cov khoom noj khoom haus rau nws cov txiaj ntsig ntawm tes thiab paj hlwb. Tshaj li 80% ntawm cov khoom lag luam ntxiv siv cov ntsev disodium vim nws txhim kho kev ruaj ntseg thiab bioavailability.
Ntsiab nta
- Tshuaj formula: C₁₄H₄N₂Na₂O₈ (Molecular Luj: 374.17)
- Cov tsos mob: Reddish-xim av rau liab-txiv kab ntxwv zoo hmoov
- Purity: ≥98% (HPLC txheeb xyuas)
- Solubility: 3 g / L hauv dej ntawm 25 ° C
- Lub neej txee: ruaj khov rau 36 lub hlis thaum khaws cia rau hauv cov thawv ntim, kom deb ntawm lub teeb thiab noo noo.
Cov txiaj ntsig kev noj qab haus huv
- Boosts Cellular Zog: PQQ activates mitochondrial biogenesis, txhim kho ATP ntau lawm thiab cellular vitality.
- Txhawb Kev Paub Txog Kev Ua Haujlwm: Cov kev tshawb fawb soj ntsuam pom tau tias txhim kho kev nco, kev nkag siab yooj yim, thiab kev ua haujlwm ceev, tshwj xeeb tshaj yog cov neeg laus (20-40 xyoo).
- Antioxidant & Neuroprotective Effects: Neutralizes dawb radicals, txo oxidative kev nyuaj siab, thiab txhawb kev loj hlob ntawm paj hlwb (NGF) synthesis.
- Cardiovascular Health: Tiv thaiv oxidative puas hauv cov hlab ntsha thiab txhawb lub plawv ua haujlwm.
- Anti-Aging Potential: Txhim kho daim tawv nqaij noj qab haus huv los ntawm kev txo oxidative puas tsuaj thiab txhim kho collagen synthesis.
Daim Ntawv Thov & Siv
- Daim Ntawv Pom Zoo: Pom zoo noj txhua hnub: 10–20 mg rau kev noj qab haus huv; Cov koob tshuaj ntau dua (txog 40 mg) tuaj yeem siv tau raws li kev saib xyuas kho mob.
- Capsules/Softgels: 10–20 mg (feem ntau ua ke nrog CoQ10 rau kev sib koom ua ke).
- Powders/Liquids: 7–20 mg per servings, zoo tagnrho rau cov dej sib tov los yog cov khoom noj ua haujlwm.
- Formulation Flexibility:
- PQQ Disodium Salt: Dej-soluble, haum rau tshuaj ntsiav, ntsiav tshuaj, thiab hmoov dej haus.
- PQQ Acid: Roj-soluble, zoo tagnrho rau softgels thiab emulsified dej haus.
Zoo & Kev Nyab Xeeb
- Kev Xeem Thib Peb: Txheeb xyuas qhov purity (≥98%) thiab cov ntsiab lus ntawm cov hlau tsis tshua muaj hnyav (lead ≤0.5 ppm, arsenic ≤1 ppm).
- Kev Nyab Xeeb Profile: Feem ntau lees paub tias muaj kev nyab xeeb (GRAS) ntawm cov koob tshuaj pom zoo. Tham nrog tus kws kho mob yog tias cev xeeb tub, saib xyuas neeg mob, lossis noj tshuaj.
- Cia: Khaws rau hauv qhov txias, qhuav (2-8 ° C) kom ruaj khov.
Cov ntsiab lus tseem ceeb
- Natural Sources vs. Supplements: Thaum PQQ muaj nyob rau hauv cov khoom noj, supplementation yog tsim nyog los ua kom tiav cov tshuaj kho tau zoo.
- Regulatory Status: Pom zoo raws li cov khoom noj tshiab hauv EU thiab Tuam Tshoj, nrog rau kev tshawb fawb txuas ntxiv los nthuav cov ntawv thov
