5-Aminolevulinic acid Phosphate (ALA)

Nkọwa dị mkpirikpi:

5-ALA bụ ngwakọta nke tetrahydropyrrole (nke bụ ihe mejupụtara heme, cytochrome, na vitamin B12). Amino acid sitere n'okike nke 5-amino acetylpropionic acid (5-ALA) nwere mmetụta mgbochi na Coronavirus! Enwere ike igbu Coronavirus n'ime ahụ mmadụ mgbe amino acid 5-ALA ruru ntakịrị mkpokọta.

Ọnụ ahịa FOB:US 5-2000/KG

Ọnụ ọgụgụ nke Min.1KG

Ikike inye:10000 KG / kwa ọnwa

Port:Shanghai/Beijing

Usoro ịkwụ ụgwọ:L/C,D/A,D/P,T/T,O/A

Usoro mbupu:Site n'oké osimiri/Site n'ikuku/Site na ozi

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Nkọwa ngwaahịa

Mkpado ngwaahịa

Aha ngwaahịa: 5-aminolevulinic acid phosphate

Otu okwu:5-ALA

CAS Mba:868074-65-1

Ịdị ọcha: ≧98.0%

Agba: Agba odo ruo ọcha

Ọnọdụ GMO: GMO efu

Mbukota: na 25kgs fiber drum

Nchekwa: Debe akpa na-emegheghị n'ebe dị jụụ, ebe kpọrọ nkụ, zere ọkụ siri ike

Ndụ shelf: ọnwa 24 site na ụbọchị mmepụta

5-Aminolevulinic acid phosphate.ALA) Nkọwa ngwaahịa

Nchịkọta ngwaahịa

5-Aminolevulinic Acid Phosphate (5-ALA phosphate)bụ ihe sitere n'okike nke amino acid, nke a ma ama maka oke ọrụ ya na usoro ndu dịka heme na chlorophyll biosynthesis. Site na nọmba CAS 868074-65-1, ọ na-apụta dị ka ntụ ntụ na-acha ọcha na-acha ọcha ma dị na ọkwa nri (95% ịdị ọcha) na ọkwa ọkwa ọgwụ (98% ịdị ọcha). Usoro ihe omimi ya bụ C5H12NO7P (ihe dị arọ: 229.125), ọ na-egosiputa nnukwu solubility na mmiri (50 mg / mL).

Ngwa igodo

Ojiji ọgwụ & Ọgwụgwọ
- Usoro ọgwụgwọ fotodynamic (PDT):ALAbụ pro-ọgwụ ghọrọ protoporphyrin IX (PpIX), a photosensitizer eji elekwasị anya na-ebibi mkpụrụ ndụ cancer n'okpuru kpọmkwem ìhè wavelengths. Ọ bụ FDA-akwadoro maka resection glioma na ọgwụgwọ ọrịa kansa anụ ahụ.
- Nlekọta Atherosclerosis: Nnyocha na-egosi usoro ọgwụgwọ sonodynamic nke ALA na-eme ka ọ na-ebelata nhazi plaque site na ịkwalite ọrụ macrophage.
- Onyonyo nchọpụta: ALA na-ebute fluorescence na-enyere aka na nhazi akpụ akpụ n'oge ịwa ahụ.
Ngwa ọrụ ugbo
- Dị ka onye na-ahụ maka uto ihe ọkụkụ, ALA na-eme ka photosynthesis, iku ume na ndidi na nrụgide, na-eme ka mkpụrụ osisi na ịdị mma dịkwuo mma.
Ụlọ ọrụ ịchọ mma
- Usoro nke nwere ALA na-eme ka hydration akpụkpọ ahụ dịkwuo mma ma belata wrinkles, yana ule ụlọ ọgwụ na-egosi ịdị irè na obere doses (dịka, 31 ng / ụbọchị).

Nchekwa & Pharmacokinetics

Profaịlụ nchekwa: ALA phosphate nwere obere dose anabatara nke ọma. bioavailability nke ọnụ na-eru 100%, yana 34% wepụ na-agbanweghị na mmamịrị n'ime awa 12. Ọmụmụ ihe izizi na-egosi na ọ nweghị nsi dị mkpa na usoro ọgwụgwọ akwadoro.
Ịkpachara anya: ALA karịrị akarị nwere ike ịkpata nrụgide oxidative n'ọnọdụ ndị a na-adịghị ahụkebe (dịka ọmụmaatụ, porphyria), mana ojiji a na-achịkwa na-ebelata ihe egwu.

Mmepụta & Ogo

Mmekọrịta dị elu: E mere yaE. coliụdị (dịka ọmụmaatụ, PIECE) na-ebuli mmepụta ALA site na ntụgharị mgbanwe mgbanwe metabolic, na-enweta ihe ruru 8.21 g/L.
Ụkpụrụ siri ike: Ngwaahịa anyị na-agbaso ụkpụrụ GMP, na-ahụ na ọ na-agbanwe agbanwe maka ngwa ọgwụ na nri.

Nkwakọ ngwaahịa & Nchekwa

Nkwakọ ngwaahịa: Ọ dị na 25 kg / drum (ụlọ ọrụ mmepụta ihe) ma ọ bụ 1 kg / akpa (iji nyocha).
Nchekwa: Chekwaa n'ime ihe mkpuchi mkpuchi, ọkụ na 2-8 Celsius C iji kwado nkwụsi ike ruo afọ 2.