Igama Lomkhiqizo: 5-aminolevulinic acid Phosphate
Igama elifanayo:5-ALA
Inombolo ye-CAS:868074-65-1
Ubumsulwa: ≧ 98.0%
Umbala: Impuphu ephuzi kuya komhlophe okhanyayo
Isimo se-GMO: Ayinayo i-GMO
Ukupakisha: kuma-drum e-fiber angu-25kgs
Indawo Yokugcina: Gcina isitsha singavulwanga endaweni epholile, eyomile, Gcina kude nokukhanya okunamandla
Impilo Yeshelufu: Izinyanga ezingama-24 kusukela ngosuku lokukhiqizwa
I-5-Aminolevulinic Acid Phosphate (I-ALA) Incazelo Yomkhiqizo
Ukubuka Konke Komkhiqizo
I-5-Aminolevulinic Acid Phosphate (i-5-ALA phosphate)iyi-amino acid etholakala ngokwemvelo, eyaziwa kabanzi ngendima yayo ebalulekile ezinqubweni zebhayoloji ezifana ne-heme kanye ne-chlorophyll biosynthesis. Ngenombolo ye-CAS868074-65-1, ibonakala njengempuphu yekristalu emhlophe kuya kwemhlophe futhi itholakala emafomuleni ebanga lokudla (ubumsulwa obungama-95%) kanye nezinga lemithi (ubumsulwa obungama-98%). Ifomula yayo yama-molecule yi-C5H12NO7P (isisindo sama-molecule: 229.125), futhi ikhombisa ukuncibilika okuphezulu emanzini (50 mg/mL).
Izinhlelo Zokusebenza Eziyinhloko
- Ukusetshenziswa Kwezokwelapha Nokwelapha
- Ukwelashwa Nge-Photodynamic (PDT): I-ALA iyisidakamizwa esisekela ukuguqulwa sibe yi-protoporphyrin IX (PpIX), i-photosensitizer esetshenziselwa ukukhomba nokubhubhisa amangqamuzana omdlavuza ngaphansi kwamaza athile okukhanya. Ivunyelwe yi-FDA ukususwa kwe-glioma kanye nokwelashwa komdlavuza wesikhumba.
- Ukuphathwa kwe-Atherosclerosis: Izifundo zibonisa ukuthi ukwelashwa kwe-sonodynamic okwenziwa yi-ALA kunciphisa ukwakheka kwe-plaque ngokuthuthukisa umsebenzi we-macrophage.
- Ukuthwebula Izithombe: Ukukhanya okubangelwa yi-ALA kusiza ekutholeni indawo eqondile yesimila ngesikhathi sokuhlinzwa.
- Izicelo Zezolimo
- Njengomlawuli wokukhula kwezitshalo, i-ALA ithuthukisa i-photosynthesis, ukuphefumula, kanye nokubekezelela ukucindezeleka, ithuthukisa isivuno sezitshalo kanye nekhwalithi.
- Imboni Yezimonyo
- Imithi equkethe i-ALA ithuthukisa umswakama wesikhumba futhi inciphise imibimbi, kanti izivivinyo zemitholampilo zibonisa ukusebenza kahle ngemithamo ephansi (isb., 31 ng/ngosuku).
Ukuphepha kanye ne-Pharmacokinetics
- Iphrofayili Yokuphepha: I-ALA phosphate yomthamo ophansi ibekezelelwa kahle. Ukutholakala kwe-bioavailability ngomlomo kufinyelela ku-100%, kanti u-34% ukhishwa engashintshiwe emchameni zingakapheli amahora ayi-12. Izifundo zangaphambi kokwelashwa aziqinisekisi ubuthi obubalulekile kumithamo enconyiwe.
- Isexwayiso: I-ALA eningi kakhulu ingabangela ukucindezeleka kwe-oxidative ezimweni ezingavamile (isb., i-porphyria), kodwa ukusetshenziswa okulawulwayo kunciphisa izingozi.
Ukukhiqizwa Nekhwalithi
- Ukwenziwa Okuthuthukisiwe: Okwenziwe NgobunjiniyelaI-E. coliizinhlobo (isb., PIECE) zithuthukisa ukukhiqizwa kwe-ALA ngokuqondisa kabusha i-metabolic flux, zifinyelela isivuno esifinyelela ku-8.21 g/L.
- Izindinganiso Eziqinile: Umkhiqizo wethu uhambisana neziqondiso ze-GMP, oqinisekisa ukuhambisana kwezicelo zemithi nokudla.
Ukupakisha Nokugcina Izinto
- Ukupakisha: Kutholakala ngo-25 kg/isigubhu (sezimboni) noma ngo-1 kg/isikhwama (ukusetshenziswa kocwaningo).
- Indawo Yokugcina: Gcina ezitsheni ezivaliwe, ezivikelwe ukukhanya ku-2–8°C ukuze kugcinwe ukuqina kuze kube yiminyaka emibili.
Kungani Kufanele Sikhethe i-ALA Phosphate Yethu?
- Imisebenzi Eminingi: Ukusetshenziswa okuhlukahlukene kwezokwelapha, ezolimo, kanye nezimonyo.
- Ukuhlanzeka Okuphezulu: I-QC eqinile iqinisekisa ubumsulwa obungu-≥95% (ukudla) kanye no-≥98% (imithi).
- Ucwaningo Olusekelwe: Lusekelwa yizivivinyo zemitholampilo kanye nezifundo ze-metabolic.
Amagama angukhiye:5-ALAi-phosphate, i-heme biosynthesis, ukwelashwa nge-photodynamic, umlawuli wokukhula kwezitshalo, i-CAS 868074-65-1
