Igama lomkhiqizo: 5-aminolevulinic acid Phosphate
Igama elifanayo:5-ALA
Inombolo ye-CAS:868074-65-1
Ubumsulwa:≧98.0%
Umbala:Ophuzi okhanyayo ukuya kumpushana omhlophe
Isimo se-GMO:GMO Mahhala
Ukupakisha: ku-25kgs fiber drums
Isitoreji: Gcina isitsha singavulwa endaweni epholile, eyomile, gwema ukukhanya okuqinile
I-Shelf Life: izinyanga ezingu-24 kusukela ngosuku lokukhiqiza
I-5-Aminolevulinic Acid Phosphate (I-ALA) Incazelo Yomkhiqizo
Uhlolojikelele Lomkhiqizo
I-5-Aminolevulinic Acid Phosphate (5-ALA phosphate)iwukuphuma ngokwemvelo kwe-amino acid, eyaziwa kabanzi ngendima yayo ebalulekile ezinqubweni zebhayoloji njenge-heme ne-chlorophyll biosynthesis. Ngenombolo ye-CAS engu-868074-65-1, ibonakala iyimpushana yekristalu emhlophe ukuya kokumhlophe futhi itholakala ekwenziweni kwebanga lokudla (ubumsulwa obungama-95%) kanye nebanga lezemithi (ubumsulwa obungama-98%) . Ifomula yayo yamangqamuzana ithi C5H12NO7P (isisindo samangqamuzana: 229.125), futhi ibonisa ukuncibilika okuphezulu emanzini (50 mg/mL) .
Izinhlelo zokusebenza ezibalulekile
- Ukusetshenziswa Kwezokwelapha Nokwelapha
- I-Photodynamic Therapy (PDT):I-ALAiwumuthi osetshenziswayo oguqulelwe ku-protoporphyrin IX (PpIX), i-photosensitizer esetshenziselwa ukukhomba nokubhubhisa amangqamuzana omdlavuza ngaphansi kwamaza okukhanya athile. Kugunyazwe i-FDA ekususeni i-glioma kanye nokwelashwa komdlavuza wesikhumba.
- Ukulawulwa Kwe-Atherosulinosis: Ucwaningo lukhombisa ukwelapha kwe-sonodynamic okuphakathi kwe-ALA kunciphisa ukwakheka kwama-plaque ngokuthuthukisa umsebenzi we-macrophage.
- I-Diagnostic imaging: Izinsiza ze-fluorescence ezenziwe yi-ALA ekutholakaleni kwasendaweni okunembile kwesimila phakathi nokuhlinzwa.
- Izicelo Zezolimo
- Njengomlawuli wokukhula kwezitshalo, i-ALA ithuthukisa i-photosynthesis, ukuphefumula, nokubekezelela ingcindezi, ithuthukise isivuno nekhwalithi .
- Imboni yezimonyo
- Ukwakheka okuqukethe i-ALA kuthuthukisa ukugeleza kwamanzi kwesikhumba futhi kunciphise imibimbi, ngokuhlolwa komtholampilo okubonisa ukusebenza kahle ngemithamo ephansi (isb, 31 ng/ngosuku).
Ukuphepha & Pharmacokinetics
- Iphrofayili Yokuphepha: Idosi ephansi ye-ALA phosphate ibekezelelwa kahle. I-bioavailability yomlomo ifinyelela ku-100%, kanti u-34% ukhishwa ungashintshiwe emchamweni phakathi kwamahora ayi-12. Ucwaningo lwangaphambi komtholampilo aluqinisekisi ubuthi obubalulekile kumithamo enconyiwe.
- Isexwayiso: I-ALA eyeqile ingase ibangele ingcindezi ye-oxidative ezimweni ezingavamile (isb, i-porphyria), kodwa ukusetshenziswa okulawulwayo kunciphisa izingozi.
Ukukhiqiza & Ikhwalithi
- I-Advanced Synthesis: EyakhiweE. coliizinhlobo (isb., I-PIECE) zilungiselela ukukhiqizwa kwe-ALA ngokuqondisa kabusha kwe-metabolic flux, ithola isivuno esingafika ku-8.21 g/L .
- Amazinga Aqinile: Umkhiqizo wethu uthobela imihlahlandlela ye-GMP, uqinisekisa ukuvumelana kwezicelo zemithi nokudla .
Ukupakisha & Isitoreji
- Ukupakishwa: Kutholakala nge-25 kg/drum (yezimboni) noma 1 kg/isikhwama (ukusetshenziswa kocwaningo) .
- Isitoreji: Gcina ezitsheni ezivaliwe, ezivikeleke kalula ku-2–8°C ukuze ugcine uzinzo kuze kube iminyaka engu-2.
Kungani Khetha I-ALA Phosphate Yethu?
- I-Multifunctional: Izicelo ezihlukahlukene kwezokwelapha, ezolimo, nezimonyo.
- Ukuhlanzeka Okuphezulu: I-QC eqinile iqinisekisa ≥95% (ukudla) kanye ≥98% (pharma) ubumsulwa.
- Ucwaningo-Kusekelwe: Kusekelwa izivivinyo zomtholampilo kanye nezifundo ze-metabolic.
Amagama angukhiye: I-5-ALA phosphate, i-heme biosynthesis, ukwelashwa kwe-photodynamic, isilawuli sokukhula kwezitshalo, i-CAS 868074-65-1
