PRL-8-53, o le nootropic fou, lea foi ua iloa i lona igoa vailaau Methyl 3- [2-[benzyl (methyl) amino] ethyl] benzoate o se faaopoopoga nootropic gaosi. Na atiina ae i le 1970 o le e Dr. Nikolaus Hansl i Creighton Iunivesite i Nebraska. Ua i ai ni suesuega o tagata na faaalia ai tali lelei i galuega tauave o le mafaufau. Se tasi o suesuega na faaalia ai e mafai ona fesoasoani le lotoa aumai manatua leiloa (hypermnesia).
Igoa oloa: PRL-8-53
Isi Igoa: Methyl 3- (2-(benzylmethylamino) ethyl) hydrochloride benzoate
3- (2-benzylmethylaminoethyl) hydrochloride ester methyl acid benzoic
3- (2-(Methyl (phenylmethyl) amino) ethyl) hydrochloride ester methyl acid benzoic
Numera CAS: 51352-87-5
Assay: 98%
Foliga Vaaia: efuefu White
E faapefea ona galue PRL-8-53?
PRL-8-53 e maua mai i le tuufaatasiga o benzoic acid ma phenylmethylamine. Le faatulagaga vailaau e maua mai le tuufaatasiga o nei tuufaatasi lua taunuuga i se lotoa e mafai ona fegalegaleai ma receptors cholinergic, lea o loo aofia ai i modulating manatua ma aoao faiga i totonu o le faiʻai. PRL-8-53 ua foi ua iloa e le potentiate (faateleina le aafiaga o) dopamine ma taofiofia vaega receptors serotonin. talitonu Dr. Nikolaus Hansl o le a ono taitaia lenei talaaga aafiaga i se suiga o le paleni i CNS faiga neurotransmitter ma taitai atu ai faagaoioiga atamai faaleleia.
Ua na o se tasi o tagata suesue togafitiga preformed e iloilo le aafiaga o le fualaau faasaina ma faaalia se faaleleia i manatua upu, taimi tali vaaia ma pulea afi, aemaise lava i latou i luga o le tausaga o le 30. matutua tagata taumafai ia avea atili e noatia i manatua ma le faaitiitia o le mafaufau, o lea, manatua ma faaopoopo Siitia faapitoa o le mafaufau e matele lava ina galulue e sili atu ia i latou.
RPL-8-53 Galuega tauave:
Faaleleia ai le atamai o le mafaufau
Faaleleia manatua ma faalagolago gafatia
Faaleleia faiai mana e foia ai faafitauli ma puipuia ai mai so o se vailaau po o se manuʻa faaletino
Faaleleia tulaga uunaiga
Faaleleia o le faafoega o auala faiai subcortical / cortical
Faaleleia vaaiga sensory
Inumaga ma le itu aafiaga
O le pateni faamatalaga avanoa mo PRL 8-53 fautuaina le tele o 0.01-4mg / kg o bodyweight. Ae peitai, e pei o se vaega tele lava e faapea, o le vaega e aupito lelei o 0.05-1.2 mg / kg. O lenei faaliliuina e 3.4mg-81.6mg mo se 150 pauna tagata ma 4.55mg-109mg mo se tagata le 200 pauna. I le faamasinoga o tagata, na tusia se aafiaga itu; Ae peitai, na matauina faaitiitia gaoioiga afi i isumu ma isumu pe a tuuina inumaga tele o PRL 8-53
