igoa ole oloa:Piperlonguminepauta
Isi Igoa: Piplartin, Piperlongumine extract, Piplartine, 5,6-Dihydro-1- [(2E) -1-oxo-3-(3,4,5-trimethoxyphenyl) -2-propen-1-yl] -2(1H) -pyridinone,PPLGM, pippali powder, Piper Longum extract
Numera CAS:20069-09-4
Punavai Fa'asao:Piper Longum Linn
Su'ega: 98% min
Fa'ata'ita'iga fua: Avanoa
Fa'aaliga: Pa'epa'e tioata pa'epa'e
Faamanuiaga: Anti-kanesa, anti-matua, senolytic
Soifua Fa'asao: 2 tausaga
Piperlongumine Powder| Mama maualuga (98%+) | CAS 20069-09-4 | Mo Su'esu'ega Fa'aaogā
Va'aiga lautele o oloa
Piperlongumine (Piplartine), o se alkaloid bioactive e maua mai lePiper longumla'au, ose mea fa'anatura fa'atasi ai ma mea e fa'agata ai le kanesa. E faʻamalosia lelei ituaiga okesene (ROS) i sela o le kanesa, e oʻo atu ai i le apoptosis e aunoa ma le afaina ai o sela masani, ma avea ai ma sui tauva mo suʻesuʻega oncology.
Vaega Autu
- Mama: ≥98% (fa'amaonia HPLC)
- Numera CAS: 20069-09-4
- Fuafuaga mole: C₁₇H₁₉NO₅
- Malosi mole: 317.34 g/mol
- Fa'aaliga: Pa'epa'e i le pa'epa'e pa'epa'e
- Solubility: E le mafai ona solu ile vai; solu i le DMSO (≥10.45 mg/mL), ethanol, ma isi solvents organic
- Teuina: Teu i le -20°C i se si'osi'omaga mago, pogisa. Stable mo le 3 tausaga .
Mechanism of Action
O le Piperlongumine e fa'atatau tonu i sela o le kanesa e ala i le tele o auala:
- ROS Induction: Faʻateleina le maualuga o le ROS intracellular, faʻaosoina faʻamaʻi faʻamaʻi ma apoptosis i sela o le kanesa.
- GSTP1 Inhibition: Taofi le glutathione S-transferase Pi 1 (GSTP1), faʻalavelave le paleni redox i sela leaga.
- STAT3 Pathway Taofi: Faʻasalaina STAT3 faʻailoga, faʻaitiitia le faʻateleina o le tuma ma le ola.
- Thioredoxin Reductase (TrxR1) Taofi: E le mafai ona faʻaogaina le toega selenocysteine, faʻaleleia le chemosensitivity.
Talosaga Suesuega
- Togafitiga o le Kanesa:
- Fa'aoso apoptosis i le susu, prostate, ma laina sela o le myeloma (IC₅₀: 1–5 μM) .
- Fa'atasi ma vaila'au o le chemotherapy (fa'ata'ita'iga, doxorubicin, cisplatin) e fa'ato'ilalo ai le tete'e atu i vaila'au.
- Su'esu'ega Auala Fa'ailoga:
- Faʻatonu auala NF-κB, MAPK, ma JAK / STAT3 .
- Neuroprotection ma le matua:
- Lagolagoina le soifua maloloina o le neuronal ma faʻaitiitia le faʻamaʻi faʻamaʻi i faʻataʻitaʻiga faʻatausaga.
- Su'esu'ega fatu:
- Taofi le atherosclerosis e ala i le taofiofia o le faateleina o maso lamolemole vascular.
Fa'amatalaga o oloa
| Tele o le afifi | Fomu | mama |
|---|---|---|
| 10 mg | Lyophilized pauta | ≥98% |
| 50 mg | Lyophilized pauta | ≥98% |
| Poloaiga Fa'apitoa | Avanoa i luga ole talosaga |
Taulimaina & Saogalemu
- Toe fa'aleleia: Fa'amuta i DMSO moin vitrosu'esu'ega. Moi le vivofa'aoga, fa'aaoga le polysorbate 80 po'o le cyclodextrin fa'avae fa'avae e fa'aleleia ai le solubility .
- Mausalī: Mausalī ile pH 4–7. Aloese mai le fa'a'umi'umi o le malamalama ona o le fa'aleagaina o ata.
- Saogalemu Fa'amatalaga: Mo su'esu'ega fa'aoga. E le'i fa'amoemoeina mo fa'ama'i po'o fa'ata'ita'iga.
Aisea e Filifili ai a matou Piperlongumine?
- Faʻamautinoaga Maualuga Maualuga: QC malosi e ala ile HPLC ma MSDS/COA faʻamaumauga.
- Avanoa Tele: Fa'asologa fa'apitoa mo mana'oga su'esu'e tetele .
- Tausisia i le Lalolagi: Fa'amalieina tulaga fa'ava-o-malo mo vaila'au fa'a'ese'ese.
Fa'asinomaga
- Filifiliga faʻamaʻi faʻamaʻi e ala i le ROS induction.
- Faʻaleleia le aoga i togafitiga faʻatasi .
- Solubility ma mautu talaaga otooto .
upu autu: Piperlongumine paʻu, suʻesuʻega faʻamaʻi, ROS induction, STAT3 inhibitor, alkaloid maualuga-mama.
