Tetrandrine Powder

Short Description:

Tetrandrine powder (Tet), also known as Hanfangchin A, is derived from the dried root of the plant Stephania tetrandra S. Moore. It’s a bisbenzyl isoquinoline chemical, and it’s an alkaloid. It expells wind, eases pain, benefits water, and reduces swelling, according to the Compendium of Materia Medica.

  • FOB Price: US $0.5 - 2000 / KG
  • Min.Order Quantity: 1 KG
  • Supply Ability: 10000 KG/per Month
  • Payment Terms: L/C,D/A,D/P,T/T
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  • Product Detail

    Product Tags

    Product Name Tetrandrine Bulk Powder
    Botanical Name 1.     Stephania tetrandra S. Moore (Fam. Menispermaceae),2. Cocculus trilobus (Thunb.) DC. (Family: Menispermaceae) ,3.Aristolochia fang chi Wu et L. D. Chou et S. M. Hwang (family: Aristolochiaceae)
    Other Names Fanchinine, hanfangchin A, NSC 77037, (S,S)-(+)-tetrandrine, sinomenine A, TTD, tetrandrin, d-tetrandrine, and GW-201
    CAS Number 518-34-3
    Molecular Formula C38H42N2O6
    Molecular Weight 622.73
    Appearance White to off white powder
    Specifications 10%, 98%
    Package 1kg/bag, 25kg/drum

    What is Tetrandrine?

    Tetrandrine powder (Tet), also known as Hanfangchin A, is derived from the dried root of the plant Stephania tetrandra S. Moore. It’s a bisbenzyl isoquinoline chemical, and it’s an alkaloid. It expells wind, eases pain, benefits water, and reduces swelling, according to the Compendium of Materia Medica.

    Tetrandrine Structural Formula

    Scientists discovered it had anti-inflammatory, analgesic, systolic, anti-silicosis, hypoglycemic, anti-free radical damage, anti-liver fibrosis, and other anti-tumor pharmacological actions as the modern medical study progressed.

    Tetrandrine plant and root

    It is clinically used for simple silicon lung and coal silicon lung; the latest research shows that it may also be an adjunctive treatment for COVID-19.

    Tetrandrine Plant Sources:

    Stephania tetrandra Powder is extracted from Fourstamen Stephania Root, a pure wild medicinal herb growing on the edge of mountainous hills, grasses, or dwarf forests, in the formation below one meter deep, dry and drought-resistant.

    The growth cycle is prolonged due to the absence of nutrients in deep soil, and the overall powder defense must grow underground for several years if not more than ten years.

    Tetrandrine Specifications :

    Tetrandrine solubility is not good, insoluble in water, petroleum ether, soluble in ethanol, etc.

    To meet different brands’ requirements, we developed several specifications.

    • Soluble in Alcohol: Tetrandrine 10% powder, Tetrandrine 98% powder
    • Soluble in Water: Tetrandrine 98% (Cosmetic Grade)

    How does Tetrandrine work?

    According to new research, Tetrandrine reduces Ebola virus infection in vitro and in vivo by blocking endosomal calcium channels. Tetrandrine can also protect cells from oxidative stress by inhibiting lipid peroxidation and reducing the generation of reactive oxygen species (ROS).

    How does Tetrandrine Work

    Mechanism of Action in COVID-19 treatment

    Tetrandrine has the potential effect on treating COVID-19. The mechanism of action is its ability to block two-pore channel 2 (TPC2) in host cells, thereby inhibiting viral replication at low micromolar concentrations.

    Tetrandrine VS Fangchinoline

    Stephania tetrandra contains a variety of isoquinoline alkaloids, Tetrandrine, fangchinoline, cyclanoline, dimethyltetrandrine, berbamine, etc.

    Tetrandrine and fangchinoline are the main active ingredients. They have the same color and similar functions.

    Both have two tertiary amine nitrogen atoms, which are more alkaline. In addition, there are derivatives of dibenzyl isoquinoline, which are more lipophilic.

    The difference is that in molecular structure, one in the seven positions is a methoxy group, and the other is a phenolic hydroxyl group, so the polarity of methyl is less than that of ethyl.

    Pharmaceutical Name Fangchinoline
    Other Name Hanfangichin B
    CAS Number 518-34-3
    Molecular Formula C37H40N2O6
    Molecular Weight 608.71
    Appearance White to off white powder
    Specification 98%
    Package 1kg/bag, 25kg/drum
    Shipment by international courier, by air, by sea

    Tetrandrine VS Fangchinoline

    Tetrandrine Manufacturing Process

    • Extraction. After the powder anti-self, raw material is crushed to reach about 20 mesh, and it is taken three times with 95% ethanol thermal reflux. Finally, the extract is concentrated with an extract of 1.2 specific gravity.
    • Precipitation. The extracted extract was added to the appropriate concentration of hydrochloric acid, washed several times, let stand to filter the insoluble, adjusted the PH value with ammonia, and purified the precipitation after the precipitation
    • Chromatography. After dissolving the sediment, it was mixed into an appropriate amount of silica gel, dried with 200-300 silica gel ethyl acetate, cyclohexane gradient chromatography, TLC detection, separation of tetrandrine VS fangchinoline, and concentrated in segments
    • Crystallization. The obtained 95% of Tetrandrine is repeatedly crystallite zed with ethanol and acetone so that the content of Tetrandrine is more than 98%.
    • Crush and dry. The resulting product is placed in phosphorus pentoxide and dried at a constant temperature in a vacuum drying box for 48 hours.
    • Inspection of packaging. The finished product is sampled and tested according to the enterprise standard and packaged into storage after passing.

    Tetrandrine benefits

    Calcium ion channel obstruction effect

    Abnormal calcium ion signaling and elevated concentration of calcium ions in the cytoplasm are the pathophysiological basis of various diseases. By inhibiting the influx of extracellular calcium ions, the powder tetrandrine intervenes in the distribution of intracellular calcium ions and maintains intracellular calcium homeostasis, blocking the relevant pathological processes.

    Immune Health

    Clinically, plant powder Tet is often used to treat autoimmune diseases like rheumatoid arthritis. And its main biologically active ingredient, Tetrandrine, has a robust immunomodulatory function.

    Induce apoptosis

    Powder hanfangchin A time and dose dependence inhibit the proliferation of human leukemia cell line U937 and cell clonal formation.

    Reverse multi-drug resistance

    Tumor cell MDR is the key to influencing the effectiveness of cancer chemotherapy. Powdered Tet can enhance the cytotoxicity of MDR-related drugs by modulating P-pg.

    Clinical Application of Tetrandrine

    As a traditional Chinese medicine, Tetrandrine belongs to the bladder, lung, and green meridian. The function benefits water, dispels wind and detumescence, and relieves pain. It is used for edema, swelling, rheumatism, lousy urination, beriberi,  and eczema. It will also show great function if used as a nutrition supplement.

    Allergy Relief

    It can be used both in OTC and skincare products, for instance, Allergy masks, Allergy creams.

    Tetrandrine for skincare

    Immune system diseases

    Hanfangchin A can significantly inhibit the development of arthritis, and its effect is more potent than aspirin, which can be applied to the treatment of rheumatoid arthritis.

    Cardiovascular system diseases

    Tet has calcium antagonism and inhibits ventricular muscle cells’ T-type and L-type calcium channels. Therefore, Tetrandrine has become a method for treating paroxysmal supraventricular tachycardia.

    Beneficial for the liver

    The digestive system has a specific role in protecting liver cells and anti-liver fibrosis.

    Eye health

    Antihexyl methanol is used to treat ocular inflammation, including uveitis, keratitis, and the resulting retinopathy.

    Protect kidney

    Tetrandrine has a pronounced antagonistic effect on the acute nephrotoxic development caused by streptomycin. In addition, Tetrandrine can alleviate the apoptosis and proliferation of renal tubular epithelial cells and protect kidney function.

    Tetrandrine for tinnitus

    Tetrandrine can treat tinnitus caused by salicylic acid and by noise.

    Safety of Tetrandrine

    FDA hasn’t paid attention to this Chinese Traditional Chinese medicine (TCM) supplement.

    Re tetrandrine toxicity, overall, low levels of TET were relatively non-toxic when administered as a single dose of 20 mg/kg, 100 mg/kg, 180 mg/kg, 260 mg/kg, or 340 mg/kg, and safe when administered daily for 14 consecutive days at 90 mg/kg.

    Tetrandrine side effects

    It has a bitter and chilly temperament. Therefore, according to Traditional Chinese Medicine (TCM) theory, it is not recommended for patients with spleen and stomach deficiencies, cold, or loss of appetite, according to Traditional Chinese Medicine (TCM) theory.

    Tetrandrine recommended dosage

    • Anti-rheumatism and relief pain, 20mg——40mg/time, 3 times /day
    • Anti cancer, 40mg——60mg/time, 3 times /day
    • Anti silicosis (Pneumosilicosis), 60mg——100mg/time, 3 times /day

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