China Manufacturer for Witch Hazel Distilled Extract - CDP-CHOLINE – Tong Rui Bio

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China Manufacturer for Witch Hazel Distilled Extract - CDP-CHOLINE – Tong Rui Bio Detail:

Name：CDP-CHOLINE,CITICOLINE
Chemical name：cytidine5’-diphosphatecholine
Molecular Formula：C14H26N4O11P2
CAS:987-78-0
Einecs NO:213-580-7
Formula Weight:488.33
Apearance: Off white powder.
Purity：98%

Citicoline (INN), also known as cytidine diphosphate-choline (CDP-Choline) or cytidine 5′-diphosphocholine is nootropic. It is an intermediate in the generation of phosphatidylcholine from choline.
Studies suggest that CDP-choline supplements increase dopamine receptor densities, and suggest that CDP-choline supplementation helps prevent memory impairment resulting from poor environmental conditions. Preliminary research has found that citicoline supplements help improve focus and mental energy and may possibly be useful in the treatment of attention deficit disorder.
Citicoline has also been shown to elevate ACTH independently from CRH levels and to amplify the release of other HPA axis hormones such as LH, FSH, GH and TSH in response to hypothalamic releasing factors. These effects on HPA hormone levels may be beneficial for some individuals but may have undesirable effects in those with medical conditions featuring ACTH or cortisol hypersecretion including PCOS, type II diabetes and major depressive disorder.

Certificate of Analysis

Product Information
Product Name:	Citicoline(CDP-Choline)
CAS No.:	987-78-0
Molecular formula:	C14H26N4O11P2
Batch No.	TRB-CDP-20190620
MFG Date:	June 20,2019

Item	Specification	Test Results
Active Ingredeints
Assay(%.On Dried Base)	98.0%~102.0% by HPLC	100.30%
Physical Control
Appearance	Fine crystalline Powder	Complies
Color	White to Off White	Complies
Identification	NMR	Complies
PH	2.5~3.5	3.3
Loss on Drying	1.0% Max	0.041%
Water	1.0% Max	0.052%
5’-CMP	NMT1.0%	0.10%
Chemical Control
Heavy metals	NMT10PPM	Complies
Arsenic(As2O3)	NMT1PPM	Complies
Sulfate(SO4)	NMT 0.020%	Complies
Iron(Fe)	NMT10PPM	Complies
Chloride(Cl)	NMT 0.020%	Complies
Solvent Residual	Meeting EU/USP Standard	Complies
Microbiological Control
Total Plate Count	10,00cfu/g Max	Complies
Yeast & Mold	100cfu/g Max	Complies
E.Coli	Negative/10g	Complies
Salmonella sp.	Negative/25g	Complies
Staph Aureus	Negative/10g	Complies
Pseudomonas aeruginosa	Negative/25g	Complies
Packing and Storage
Packing	Pack in paper-drums. 25Kg/Drum 1Kg per plastic bag
Storage	Store in a well-closed container away from moisture and direct sunlight.
Shelf Life	2 years if sealed and stored properly.

More information of TRB
Regulation certification
U.S.FDA,CEP,KOSHER HALAL GMP ISO Certificates
Reliable Quality
Nearly 20 years,export 40 countries and regions,more than 2000 batches produced by TRB have no any quality problems,unique purification process,impurity and purity control meet USP,EP and CP
Comprehensive Quality System
	▲Quality Assurance System	√
	▲ Document control	√
	▲ Validation System	√
	▲ Training System	√
	▲ Internal Audit Protocol	√
	▲ Suppler Audit System	√
	▲ Equipment Facilities System	√
	▲ Material Control System	√
	▲ Production Control System	√
	▲ Packaging Labeling System	√
	▲ Laboratory Control System	√
	▲ Verification Validation System	√
	▲ Regulatory Affairs System	√
Control Whole Sources and Processes
Strictly controlled all raw material,accessories and packaging materials.Preferred raw materials and accessories and packaging materials supplier with U.S. DMF number.Several raw material suppliers as supply assurance.
Strong Cooperative Institutions to support
Institute of botany/Institution of microbiology/Academy of Science and Technology/University

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The key to our success is "Good Product or service High quality, Reasonable Rate and Efficient Service" for China Manufacturer for Witch Hazel Distilled Extract - CDP-CHOLINE – Tong Rui Bio, The product will supply to all over the world, such as: Malaysia, America, Costa Rica, we are fully determined to control the whole supply chain so as to provide quality products at competitive price in a timely manner. We are keeping up with the advanced techniques, growing through creating more values for our clients and society.

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