High reputation Z-Ligustilide - Nicotinamide riboside chloride powder – Tong Rui Bio

Product name: Nicotinamide riboside chloride powder
Other name:3-(Aminocarbonyl)-1-P-D-ribofuranosyl-pyridinium chloride(1 :1);Nicotinamide

Riboside.Cl;3-Carbamoyl-1-beta-D-ribofuranosyl-pyridinium chloride; NR, vitamin NR;Niagen, TRU NIAGEN

CAS NO:23111-00-4
Molecular formula: C11H15N2O5.Cl
Molecular Weight: 90.70 g/mol
Purity:98%
Melting Point:115℃-125℃

Appearance:Off White to Pale Yellow Powder
Use:Boosts NAD+ levels, Supports healthy Aging and brain/cognitive

Applications:as a dietary supplement, functional foods, and beverages

Recommended dosage:not more than 180 mg/day

Nicotinamide riboside is a newly appreciated form of Vitamin B3, with unique properties; it is a formal precursor of NAD+.

Nicotinamide riboside (NR), first described in 1944 as a growth factor (Factor V) for Haemophilus influenza, and in 1951, NR, first investigated as a metabolic fate in mammalian tissues.

As you may notice that, there are two forms of NR available, one is Nicotinamide Riboside, and the other is Nicotinamide Riboside chloride.

Chemically speaking, they are two completely different compounds since they have different CAS numbers, NR with 1341-23-7 while NR chloride with 23111-00-4. NR is not stable at room temperature, while NR chloride is stable. Famous patented Brand named NIAGEN®, released by Chromadex Inc in 2013, is the form of Nicotinamide riboside chloride, aiming to reverse signs of aging from inside your body. Nicotinamide Riboside manufactured from Cima Science is also in the chloride powder form. If not specified, NR will refer to the NR chloride form in the article below.

Nicotinamide riboside food sources

The amount of NR in foods is minute, compared with that in nutritional supplements. However, what are the primary food sources that contain nicotinamide riboside (NR)?

Cow milk

Cow milk usually has ∼12 μmol NAD(+) precursor vitamins/L, of which 60% was present as nicotinamide, and 40% was current as NR. (Conventional milk contained more NR than organic milk), a study published by the University of Iowa, in 2016

Yeast

An old study has stated, “One inhibitory substance was isolated from yeast and was found to be nicotinamide riboside, it may have from NAD (P) during the preparation of yeast extracts, or from dietary yeast supplements during digestion in vivo.” While there is no quantitative data on yeast

Beer

The beer has a fair amount of carbs and drinking those in a liquid form like that will have a glycemic impact; various research papers have mentioned beer as being a food source of nicotinamide riboside.

Also, there may be trace amounts of NR like whey protein, mushrooms, etc.

For many people, dairy is off limits for other reasons. The food sources of nicotinamide riboside might be useful, but are less efficient than an NR supplement.

Why Nicotinamide Riboside (NR) designate as an authentic NAD+ precursor vitamin invertebrates?

There are five lines of reasoning support it:

Haemophilus influenza, a flu-causing bacterium, which has no de novo pathway and cannot utilize Na or Nam, is strictly dependent on NR, NMN, or NAD+ for growth in the host bloodstream.

Milk is a source of NR.

NR protects murine DRG neurons in an ex vivo axonopathy assay via transcriptional induction of the nicotinamide riboside kinase (NRK) 2 gene.

Exogenously added NR and derivatives increase NAD+ accumulation in a dose-dependent fashion in human cell lines.

Candida glabrata, an opportunistic fungus that depends on NAD+ precursor vitamins for growth, utilizes NR during disseminated infection.

Nicotinamide Riboside VS Nicotinamide VS Niacin

Niacin (or nicotinic acid), is an organic compound and a form of vitamin B3, an essential human nutrient. It has the formula C6H5NO2.

Nicotinamide or called niacinamide is a form of vitamin B3 found in food and used as a dietary supplement and medication. It has the formula C6H6N2O.

Nicotinamide riboside is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+. It has the formula C11H15N2O5+.

Nicotinamide Riboside Health Benefits

Nicotinamide Riboside helps energy generation

In animals, NR supplementation reduced NAD consumption, which improved mitochondrial function, rapidly restored muscle mass, and conserve strength NAD levels and exercise volume in older mice, helping maintain muscle mass and function, supports more energy generation.

Nicotinamide Riboside improves cognitive function

NR preserves the nerve cells in the brain by activating the SIRT3, Supplementation stimulates the NAD pathways and helps prevent degeneration in mind.

NR boosted cognitive function and slowed progression of Alzheimer’s disease in mice given NR for three months.

Nicotinamide Riboside prevents hearing loss

By activating the SIRT3 pathway, a UNC study found it helped protect rodents against noise-induced hearing loss.

Nicotinamide Riboside protects the liver

Taken NR orally increases NAD in the body, which helps protect the liver. NR stopped fat accumulation, lowered oxidative stress, prevented inflammation, and improved insulin sensitivity in the liver of mice.

Furthermore, NR could extend longevity, Increases metabolism, supports the fight against cancer, reduce diabetic symptoms, increases metabolism, may help with weight loss.

Is Nicotinamide Riboside Safe?

Yes, NR is safe.

NR has three published clinical trials confirming it is safe for human consumption.

Careful analyzing and stressed all the preclinical and clinical information available on NR assure it is safe and well tolerated.

Niagen is safe and GRAS, using scientific procedures, under the Federal Food, Drug, and Cosmetic Act (FFDCA).

Nicotinamide Riboside Human Trials

There are many pre-clinical studies have been conducted testing NR in various model systems.

In 2015, the first human clinical studies completed, and the results demonstrated that NR safely and effectively boosts levels of NAD in healthy human volunteers.

A placebo-controlled clinical trial of nicotinamide riboside in obese men by randomized: safety, insulin-sensitivity, and lipid-mobilizing effects

–Published in The American/Journal of Clinical Nutrition

Results: 12 wk of NR supplementation in doses of 2000 mg/d appears safe, but does not improve insulin sensitivity and whole-body glucose metabolism in obese, insulin-resistant men.

Chronic nicotinamide riboside supplementation is well-tolerated and raises NAD+ in healthy middle-aged and older adults.

–Published in Nature Communications

Nicotinamide Riboside is Especially and Orally Bioavailable in Mice and Humans

–Published in Nature Communications

Here we define the time and dose-dependent effects of NR on blood NAD metabolism in humans. The report shows that human blood NAD can rise as much as 2.7-fold with a single oral dose of NR in pilot research of one individual and that oral NR elevates mouse hepatic NAD with apparent and superior pharm