Tangeretin 98%

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We’ve got the most highly developed manufacturing machines, experienced and qualified engineers and workers, acknowledged good quality management systems and also a friendly specialist gross sales team pre/after-sales support for China Citrus and Tangeretin, We aim to become the modern enterprise with the commercial ideal of “Sincerity and confidence” and with the aim of “Offering customers the most sincere services and best quality products”. We sincerely ask for your unchanged support and appreciate your kind advice and guidance.

What’s Tangeretin?

Tangeretin is a flavonoid that comes from citrus fruit peels. It has been proven that Tangeretin plays a vital role in anti-inflammatory responses and neuroprotective effects from several disease models.

Tangeretin bioavailability

Take rats as an example to study Tangeretin bioavailability:

The results show that the absolute oral bioavailability of tangeretin in rats was 27.11%. The main components are concentrated in the kidney, lung, and liver. And less than 8% of tangeretin is excreted in their urine or feces.

The low solubility of Tangeretin may be one of the main reasons for the low bioavailability of Tangeretin in human bodies.

TANGERETIN vs Sinensetin

Sinensetin is a polymethoxylated flavonoid that can be found in many citrus fruits. In contrast, Tangeretin is an O-polymethoxylated flavonoid found in tangerine and other citrus peels.

Tangeretin and sinensetin have the same molecular formula but different molecular structural formulas and functions for our bodies. In several disease models, Tangeretin has been proven to play a pretty important role in neuroprotective effects and anti-inflammatory responses. Sinensetin can enhance adipogenesis and lipolysis. What’s more, it possesses potent antiangiogenesis and anti-inflammatory.

TANGERETIN Specifications

• 95% ~99% Tangeretin powder
• 98% Tangeretin powder
• nobiletin + tangeretin >20% Hplc
• nobiletin + tangeretin >30% Hplc
• nobiletin + tangeretin >60% Hplc
• Shipment (by Courier like FedEx, UPS, by air, by sea)
• Package (1kg/bag, 25kg/drum)

Polymethoxylated Flavones (PMFs)

Citrus fruits are the most important and direct source of Polymethoxylated Flavones (PMFs), which significantly affect consumers’ health.

Experiments on hamsters with high cholesterol show that PMF has particular cholesterol-lowering potential in this kind of hamster. In addition, it is found that PMF can also reduce serum triacylglycerol (blood lipid). PMF is a new flavonoid with the potential of lowering cholesterol and blood lipid.

Nobiletin vs Tangeretin

Both of them, Nobiletin and Tangeretin, are flavonoids that can be isolated from citrus peels. Nobiletin is an O-methylated flavone, almost the same as Tangeretin. However, their molecular structural formulas and functions for our bodies are not the same.

Recent pieces of evidence show that Nobiletin powder is a multifunctional pharmaceutical agent. The various pharmacological activities of Nobiletin include neuroprotection, cardiovascular protection, antimetabolic disorder, anti-cancer, anti-inflammation, and antioxidation.

And what about Tangeretin? Many studies have already shown that it possesses antioxidant and anti-cancer properties.

Tamoxifen vsTangeretin

Tamoxifen is a selective estrogen receptor modulator (SERM) that is usually used to treat all stages of hormone receptor-positive breast cancer, both in women and men. In addition, Tangeretin is an effective tumor growth and invasion inhibitor of human MCF 7/6 breast cancer cells in vitro.

Tamoxifen and Tangeretin flavonoid tangeretin showed similar inhibitory effects on the growth and invasion of human breast cancer cells in vitro. However, when both of them are taken in vivo of our bodies, Tangeretin will neutralize the beneficial tumor inhibitory effect of Tamoxifen and reduce the number of natural killers of tumor cells. So it is suggested that both of them should not be taken orally simultaneously.

5-acetyloxy-6,7,8,4′-tetramethoxyflavone (5-AcTMF)

Tangeretin has been proved for its anti-cancer effect. However, its bioavailability is not good enough. A derivative of 5- acetoxy -6,7,8,4′- tetramethyl-methoxy flavone was synthesized by acetylation.

This derivative has an exceptionally effective inhibitory effect on the proliferation of human leukemia and breast cancer cells.

In addition, it has been proven in vitro studies that 5-AcTMF has cytotoxicity to MCF-7 cells by inducing intrinsic apoptosis, which indicates that 5-AcTMF has much more potent inhibitory effects on the growth of MCF-7 cancer cells than its parent compound Tangeretin.

TANGERETIN Manufacturing Process

Raw materials used include hot water, citrus fruit, solvent, dilute alkali, and methanol. The simple steps for manufacturing include:

1. Treat citrus fruit with hot water to obtain product;
2. Dry it to get a dried product;
3. Treat it with a solvent that can dissolve Tangeretin to obtain a solution;
4. Concentrate and dry Tangeretin solution to get condensate;
5. Treat the concentrate with dilute alkali to obtain composition;
6. Treat the concentrate by adding Methanol to get Tangeretin pure powder.

TANGERETIN Benefits

Reduce cancer

Numerous experiments have fully proved the tumor-inhibiting effect of Tangeretin. It has been confirmed that it can inhibit the growth and progress of several cancer cells, such as ovarian cancer, colorectal cancer, gastric cancer, and breast cancer.

Lower cholesterol

Large amounts of animal studies have already indicated that Tangeretin has cholesterol-lowering properties. One of these studies has found that rats fed with diets with Tangeretin showed reduced (nearly up to 40%) serum levels of LDL cholesterol in their bodies.

Tangeretin Parkinson

Recently, some studies have shown that Tangeretin has been proved to have a particular neuroprotective effect, and it can protect dopaminergic nerves from toxins.

Other beneficial effects of Tangeretin against Parkinson’s disease are still under study.

Fight inflammation

Tangeretin possesses five methoxy groups, respectively, showing various activities, such as anti-cancer, anti-inflammatory, and anti-obesity effects. In addition, previous studies have shown that it can regulate the inflammation and behavior of the central nervous system.

Combat osteoporosis

An experiment on OVX mice showed that the femoral bone density of OVX mice lacking estrogen decreased significantly, but after oral administration of PMFs, the bone density of the distal femur in vivo was partially recovered. This also proves that Tangeretin can combat osteoporosis to some extent.

TANGERTIN side effects

Tangeretin is generally considered a very safe compound, and there is no report that it will harm human bodies.

Tangeretin dosage

The typical dose of citrus bioflavonoids is 500mg twice a day. And of course, Tangeretin is no exception.