Wholesale Elderberry Liquid Extract - Methyl-Sulfonyl-Methane (MSM) – Tong Rui Bio

Methylsulfonylmethane (MSM) is an organosulfur compound with the formula (CH3)2SO2. It is also known by several other names including DMSO2, methyl sulfone, and dimethyl sulfone. This colorless solid features the sulfonyl functional group and is considered relatively inert chemically. It occurs naturally in some primitive plants, is present in small amounts in many foods and beverages, and is marketed as a dietary supplement. It is also commonly found in the atmosphere above marine areas, where it is used as a carbon source by the airborne bacteria Afipia, and is found distinctively in human melanoma cells.

Product Name:Methyl-Sulfonyl-Methane (MSM)

CAS No:67-71-0

Assay:99.0% min by HPLC

Series:20-40mesh  40-60mesh   60-80mesh  80-100mesh

Colour:White to off-white powder with characteristic odor and taste 

GMO Status:GMO Free

Packing: in 25kgs fiber drums

Storage:Keep container unopened in cool, dry place,Keep away from strong light

Shelf Life:24 months from date of production

Function:

Although no medical uses for MSM have been approved by any government, a variety of health benefits have been claimed and studied. Stanley W. Jacob reported having administered MSM to over 18,000 patients with a variety of ailments; he co-authored a book promoting MSM with a variety of claims, including a utility as a natural source of “biologically active sulfur,” suggesting that people are deficient in such forms of sulfur in their dietary intake. There is no Dietary Reference Intake (DRI) or Daily Value established for sulfur and sufficient dietary sources are readily available in onions, garlic and cruciferous vegetables and in protein-containing foods, including nuts, seeds, milk and eggs (whites and yolks).

The claims for the need for sulfur supplementation originate with Robert Herschler, a biochemist who patented “Dietary and pharmaceutical uses of methylsulfonylmethane and compositions comprising it” in 1982; he claimed that MSM was useful in stress, mucous-membrane inflammation, allergies and gastrointestinal conditions.

MSM is sold as a dietary supplement and marketed with a variety of claims, often in combination with glucosamine and or chondroitin for helping to treat or prevent osteoarthritis. According to one review, “The benefits claimed [for MSM] far exceed the number of scientific studies. It is hard to build a strong case for its use other than for treating arthritis problems.”

Moreover, in cases involving topical therapeutics, the role of MSM as an active agent, per se, versus its having a role in promoting skin permeation (in manner, akin to its solvent relative DMSO) must be characterized/controlled. The biochemical effects of supplemental methylsulfonylmethane are poorly understood. Some researchers have suggested that MSM has anti-inflammatory effects.The spectrum of biological effects of dimethyl sulfoxide (DMSO) and MSM differ, but those of DMSO may be mediated, at least in part, by MSM.

Herschler’s patent documents, and much of the alternative medical literature supporting MSM use, claim that “the average diet is deficient in methylsulfonylmethane because it is readily lost during conventional food processing, such as frying, dehydrating, dilution with synthetic fillers and other poorly nutritional additives, cooking, radiation or pasteurizing, and long-term storage”.

FDA action

In 2008 Bergstrom Nutrition, a U.S. manufacturer of MSM, submitted a notification to the FDA claiming generally recognized as safe (GRAS) status. The FDA responded with a letter of non-objection, functionally designating OptiMSM, the branded form of MSM manufactured by Bergstrom Nutrition, as GRAS. The designation allows MSM to be added to meal supplement and meal replacement foods, fruit smoothie-type drinks, fruit-flavored thirst quencher-type beverages, and food bars such as granola bars and energy-type bars.

Evidence from clinical trials

Small-scale studies of possible treatments with MSM have been conducted on both animals and humans. These studies of MSM have suggested some benefits, particularly for treatment of oxidative stress and osteoarthritis, but evidence for other uses is lacking. Natural Medicines Comprehensive Database contains a continually updated list of health-related MSM studies.

Safety

Extensive research in animal models indicates MSM has a very low toxicity when administered both orally and topically. In clinical trials, several studies reported minimal or absence of side effects after 12 weeks of dosing. Reported side effects from these studies included mild gastrointestinal issues, fatigue, and headache, although they did not appear to differ from placebo. A more recent 26 week study on large joint osteoarthritis observed no adverse events or abnormal changes in lab monitoring when taking 6 grams MSM per day. MSM is considered ‘Possibly Safe’ at therapeutic doses, although further research is still needed to assess its safety for long-term use.

Application:

-As Food and beverage ingredients.
-As Healthy Products ingredients.
-As Nutrition Supplements ingredients.
-As Pharmaceutical Industry & General Drugs ingredients.
-As a health food and cosmetic ingredients