Cov Covid-19, lossis lwm tus muaj npe hu ua 2019-nCoV lossis SARS-CoV-2 tus kabmob, yog tsev neeg ntawm tus kabmob Coronavirus. Raws li SARS-CoV-2 zwm rau hom kab mob Coronavirus nws tau ze rau MERS-CoV thiab SARS-CoV - uas tseem tau tshaj tawm tias ua rau muaj mob loj ntawm kev mob ntsws nyob rau yav tas los. Cov keeb kwm caj ces ntawm 2019-nCoV tau tsim thiab tau tshaj tawm. [I] [ii] Cov protein ntau hauv cov kab mob no thiab cov tau qhia yav tas los hauv SARS-CoV lossis MERS-CoV muaj qhov sib thooj ntawm lawv.
Qhov tshiab ntawm hom kab mob no txhais tau hais tias muaj ntau yam tsis paub tseeb nyob ib puag ncig nws tus cwj pwm, yog li nws tseem ntxov dhau los txiav txim siab tias cov nroj tsuag tshuaj ntsuab los yog cov tebchaw puas tuaj yeem ua rau muaj kev cuam tshuam rau cov tib neeg raws li cov tshuaj tiv thaiv kab mob lossis raws li cov khoom tsim nyog hauv tshuaj tiv thaiv cov kab mob tiv thaiv Covid -19. Txawm li cas los xij, vim tias Covid-19 muaj qhov zoo sib xws nrog yav dhau los tshaj tawm SARS-CoV thiab MERS-CoV cov kab mob, kev tshawb fawb luam tawm yav dhau los txog kev siv tshuaj ntsuab, uas tau raug pov thawj qhia tias muaj kev cuam tshuam los tiv thaiv coronavirus, tej zaum yuav yog cov lus qhia tseem ceeb los nrhiav kev tiv thaiv kabmob. tshuaj ntsuab hauv cov nroj tsuag, uas tuaj yeem tiv thaiv tus kab mob SARS-CoV-2.
Tom qab tau tawg tawm ntawm SARS-CoV, thawj zaug tau tshaj tawm thaum xyoo 2003 [iii], cov kws tshawb fawb tau sim siv ntau yam tshuaj tiv thaiv tus kabmob SARS-CoV. Qhov no tau coj pab pawg kws tshaj lij nyob hauv Suav teb tshuaj ntsuam ntau dua 200 suav tshuaj ntsuab tshuaj ntsuab rau tshuaj tiv thaiv kab mob kis rau tus kabmob no.
Ntawm cov no, plaub qhov kev nthuav tawm nthuav dav rau cov muaj txiaj ntsig inhibition muaj txiaj ntsig rau SARS-CoV - Lycoris radiata (Liab Kab laug Sab Lily), Pyrrosia lingua (fern), Artemisia annua (Sweet wormwood) thiab Lindera sib sau ua ke (ib qho uas muaj ntxhiab ib tsob ntoo ntsuab tsob ntoo hauv tsev neeg laurel )). Qhov teebmeem los tiv thaiv cov no yog cov tshuaj tiv thaiv kab mob thiab muaj nyob ntawm qhov tsis tshua muaj ntau ntawm cov extract rau qhov siab, sib txawv rau txhua qhov kev siv tshuaj ntsuab. Hauv Lycoris radiata nthuav tawm muaj kev ua haujlwm muaj txiaj ntsig tshaj plaws los tiv thaiv tus kab mob khaub thuas. [Iv]
Cov txiaj ntsig no tau zoo sib xws nrog ob ntawm lwm cov kev tshawb fawb, uas tau tawm tswv yim tias ib yam muaj txiaj ntsig nyob hauv Licorice cag, Glycyrrhizin, tau muaj pov thawj pom tias muaj kev tawm tsam los tiv thaiv SARS-CoV los ntawm kev txwv tsis pub nws rov ua dua. [V] [vi] Hauv lwm qhov kev kawm, Glycyrrhizin kuj tau nthuav tawm cov tshuaj tiv thaiv kev tiv thaiv thaum kuaj pom nws cov teebmeem hauv tshuaj tiv thaiv kab mob rau 10 yam mob sib txawv hauv SARS tus mob coronavirus. Baicalin - ib cheeb tsam ntawm cov nroj tsuag Scuttelaria baicalensis (Skullcap) - tseem tau sim hauv qhov kev tshawb fawb no nyob hauv tib qho kev mob thiab kuj tau qhia kev ua tawm tsam tus kabmob SARS coronavirus. [Vii] Baicalin kuj tseem tau pom tias yuav txwv tsis pub rov kis mob HIV -1 tus kab mob nyob rau hauv vitro hauv cov kev tshawb fawb yav dhau los. [Viii] [ix] Txawm li cas los xij nws yuav tsum nco ntsoov tias hauv kev tshawb pom hauv vitro tsis tuaj yeem cuam tshuam nrog hauv vivo cov chaw kuaj mob ua tau zoo. Qhov no yog vim qhov ncauj ntawm cov neeg sawv cev hauv tib neeg tej zaum yuav ua tsis tiav cov ntshav ntshiab zoo ib yam li ntsuas hauv vitro.
Lycorine kuj tseem pom muaj lub peev xwm tiv thaiv tus kab mob ua kom zoo tiv thaiv SARS-CoV.3 Cov ntaub ntawv dhau los qhia tias Lycorine zoo li muaj cov kev ua haujlwm tiv thaiv kab mob siab thiab tau tshaj tawm tias tau muaj kev cuam tshuam los kho tus kab mob Herpes Simplex (hom I) [x] thiab Poliomyelitis virus tseem. [xi]
"Lwm cov tshuaj ntsuab uas tau tshaj tawm tias tau ua yeeb yam tshuaj tua kabmob los tiv thaiv SARS-CoV yog Lonicera japonica (Japanese Honeysuckle) thiab cov npe hu ua Eucalyptus cog, thiab Panax ginseng (lub hauv paus) los ntawm nws txoj kev nquag Ginsenoside-Rb1."
Cov ntaub ntawv pov thawj los ntawm cov kev tshawb fawb tau hais los saum toj no thiab ntau lwm qhov kev tshawb fawb thoob ntiaj teb qhia tias ntau tus neeg siv tshuaj ntsuab tau tshaj tawm cov tshuaj tiv thaiv kab mob tiv thaiv kab mob coronaviruses [xiii] [xiv] thiab lawv lub ntsiab ntawm kev ua zoo li yog los ntawm kev txwv tsis pub kis mob. tau siv dav dav suav tshuaj ntsuab tshuaj ntsuab los kho mob SARS tau zoo nyob rau ntau qhov xwm txheej.
Cov tshuaj ntsuab no puas tuaj yeem yog cov neeg tuaj yeem coj los txhim kho cov tshuaj tshiab los tiv thaiv lossis kho tus mob SARS?
DISCLAMER: Tsab ntawv no tau sau tseg rau kev ua ntaub ntawv xov xwm nkaus xwb thiab nws tsis yog los hloov txoj kev tawm tswv yim kho mob, kuaj mob lossis kho mob. Yog koj xav tias koj muaj cov tsos mob ntsig txog Covid-19 lossis lwm yam mob, hu rau koj tus kws kho mob tam sim ntawd.
[i] Zhou, P., Yang, X., Wang, X. et al., 2020. Kab mob ntsws muaj kev cuam tshuam nrog tus kabmob tshiab ua mob rau cov phom sij. Xwm 579, 270–273 (2020). https://doi.org/10.1038/s41586-020-2012-7
[ii] Andersen, KG, Rambaut, A., Lipkin, WI, Holmes, EC thiab Garry, RF, 2020. Qhov txiaj ntsig kwv yees ntawm SARS-CoV-2. Tshuaj Tshuaj, pp.1-3.
[iii] CDC SARS Teb sijhawm. Muaj nyob ntawm https://www.cdc.gov/about/history/sars/timeline.htm. Nkag mus
[iv] Li, SY, Chen, C., Zhang, HQ, Guo, HY, Wang, H., Wang, L., Zhang, X., Hua, SN, Yu, J., Xiao, PG thiab Li, RS, 2005. Kev txheeb xyuas qhov tseeb ntawm cov tebchaw txuas nrog cov haujlwm tiv thaiv tus kabmob SARS-cuam tshuam tus kabmob coronavirus. Kev Tshawb Xyuas Antiviral, 67 (1), pp.18-23.
[v] Cinatl, J., Morgenstem, B. thiab Bauer, G., 2003. Glycyrrhizin, ib qho muaj ceem rau cov hauv paus hniav licorice thiab rov ua haujlwm ntawm SARS-cuam tshuam tus mob coronovirus. Lancet, 361 (9374), pp.2045-2046.
[vi] Qhov twg los xij, G., Baltina, L., Michaelis, M., Kondratenko, R., Baltina, L., Tolstikov, GA, Doerr, HW thiab Cinatl, J., 2005. Antiviral Yam Ntxim Saib Ntxim Ua ntawm Glycyrrhizic Acid Derivatives tiv thaiv SARS− Coronavirus. Phau ntawv teev cov tshuaj muaj tshuaj, 48 (4), pp.1256-1259.
[vii] Chen, F., Chan, KH, Jiang, Y., Kao, RYT, Lu, HT, Ntxuam, KW, Cheng, VCC, Tsui, WHW, Hung, IFN, Lee, TSW thiab Guan, Y., 2004. Hauv vitro ntxim rau 10 qhov kho mob raug SARS tus mob coronavirus rau xaiv tshuaj tiv thaiv kab mob sib txuas. Phau Ntawv Teev Cov Kev Khomob, 31 (1), pp.69-75.
[viii] Kitamura, K., Honda, M., Yoshizaki, H., Yamamoto, S., Nakane, H., Fukushima, M., Ono, K. thiab Tokunaga, T., 1998. Baicalin, tus tiv thaiv ntawm HIV-1 ntau lawm hauv vitro. Kev Tshawb Nrhiav Antiviral, 37 (2), pp.131-140.
[ix] Li, BQ, Fu, T., Dongyan, Y., Mikovits, JA, Ruscetti, FW thiab Wang, JM, 2000. Flavonoid baicalin tiv thaiv kev kis tus kabmob HIV-1 ntawm qib kev kis tus kabmob. Kev sib txuas lus ntawm biochemical thiab biophysical, 276 (2), pp.534-538.
[x] Renard-Nozaki, J., Kim, T., Imakura, Y., Kihara, M. thiab Kobayashi, S., 1989. Cov nyhuv ntawm alkaloids cais tawm ntawm Amaryllidaceae rau tus kab mob herpes simplex virus. Kev tshawb fawb hauv virology, 140, pp.115-128.
[xi] Ieven, M., Vlietinick, AJ, Berghe, DV, Totte, J., Dommisse, R., Esmans, E. thiab Alderweireldt, F., 1982. Cov tshuaj tua kab mob rau cov kab mob. III. Kev rho tawm ntawm alkaloids los ntawm Clivia miniata Regel (Amaryl-lidaceae). Phau ntawv Journal ntawm cov Khoom Uas Ntuj tsim, 45 (5), pp.564-573.
[xii] Wu, CY, Jan, JT, Ma, SH, Kuo, CJ, Juan, HF, Cheng, YSE, Hsu, HH, Huang, HC, Wu, D., Brik, A. thiab Liang, FS, 2004 . Cov me me lwg me rau lub hom phiaj mob hnyav ua pa los ntawm neeg tus mob coronavirus. Kev Txiav Txim Siab ntawm National Academy of Sciences, 101 (27), pp.10012-10017.
[xiii] Wen, CC, Kuo, YH, Jan, JT, Liang, PH, Wang, SY, Liu, HG, Lee, CK, Tseej, ST, Kuo, CJ, Lee, SS thiab Hou, CC, 2007. Tshwj xeeb cog terpenoids thiab lignoids muaj hwj chim ua kom muaj tus kab mob tiv thaiv kev ua pa nyuaj ua rau neeg muaj mob. Phau ntawv teev cov tshuaj muaj tshuaj, 50 (17), pp.4087-4095.
[xiv] McCutcheon, AR, Roberts, TE, Gibbons, E., Ellis, SM, Babiuk, LA, Hancock, REW thiab Towers, GHN, 1995. Antiviral kuaj ntawm British Columbian tshuaj ntsuab nroj tsuag. Phau ntawv Journal ntawm Ethnopharmacology, 49 (2), pp.101-110.
[xv] Jassim, SAA thiab Naji, MA, 2003. Cov neeg sawv cev tiv thaiv tau tshiab: qhov pom kev cog tshuaj. Phau ntawv Journal ntawm thov microbiology, 95 (3), pp.412-427.
[xvi] Luo, H., Tang, QL, Shang, YX, Liang, SB, Yang, M., Robinson, N. thiab Liu, JP, 2020. Cov tshuaj hauv Suav tuaj yeem siv los tiv thaiv tus kabmob corona kabmob 2019 (COVID -19)? Kev tshuaj xyuas cov keeb kwm keeb kwm, cov pov thawj tshawb fawb thiab cov kev tiv thaiv tam sim no. Cov Ntawv Xov Xwm Suav ntawm Cov Tshuaj Muaj Tshuaj, pp.1-8.
Raws li ib txwm muaj nrog yuav luag txhua lub vev xaib tshaj lij, peb lub xaib siv cov ncuav qab zib, uas yog cov ntawv me me uas rub tawm rau koj lub cuab yeej, txhawm rau txhim kho koj cov kev paub.
Cov ntaub ntawv no piav qhia txog cov ntaub ntawv uas lawv sib sau, peb siv nws li cas thiab vim li cas qee zaum peb yuav tsum khaws cov ncuav qab zib no. Peb tseem yuav qhia tawm li cas koj tuaj yeem tiv thaiv cov ncuav qab zib no ntawm kev khaws cia txawm li cas los xij qhov no yuav txo qis lossis 'tawg' qee yam ntawm cov xaib ua haujlwm.
Peb siv cov ncuav qab zib rau ntau qhov laj thawj hauv qab no. Hmoov tsis zoo, nyob rau hauv Feem ntau tsis muaj cov qauv kev lag luam rau kev txiav tawm cov ncuav qab zib tsis muaj kev cuam tshuam cov haujlwm thiab cov yam ntxwv ntxiv rau hauv lub xaib. Nws raug nquahu kom koj tawm ntawm txhua lub ncuav qab zib yog tias koj tsis paub meej tias koj xav tau lossis tsis xav tau, nyob rau hauv rooj plaub lawv tau siv los muab kev pabcuam uas koj siv.
Koj tuaj yeem tiv thaiv kev teeb tsa cov ncuav qab zib los ntawm kev kho cov chaw hauv koj lub browser (saib koj lub browser "Pab" kev xaiv seb yuav ua li cas). Nco ntsoov tias disrupt cookies yuav cuam tshuam rau lub luag haujlwm ntawm no thiab ntau lwm lub vev xaib uas koj mus ntsib. Yog li ntawd, nws raug nquahu tias koj yuav tsum tsis txhob tua cov khoom qab zib.
Qee qhov tshwj xeeb peb tseem siv cov ncuav qab zib muab los ntawm kev ntseeg thib peb. Peb lub vev xaib siv [Google Analytics] uas yog ib qho ntawm cov kev pom tseeb tshaj plaws thiab ntseeg cov kev daws teeb meem hauv lub vev xaib kom pab peb nkag siab tias koj siv lub xaib thiab cov hau kev li cas peb tuaj yeem txhim kho koj cov kev paub. Cov ncuav qab zib no tuaj yeem taug qab cov khoom xws li ntev li cas koj siv nyob rau lub vev xaib thiab cov nplooj ntawv uas koj tuaj ntsib koj thiaj li tuaj yeem tsim cov ntsiab lus txuas ntxiv. Yog xav paub ntau ntxiv txog Google Analytics ncuav qab zib, saib nplooj ntawv Google Analytics nplooj ntawv.
Google Analytics yog Google txoj kev ntsuas uas pab peb lub vev xaib kom nkag siab tias cov neeg tuaj ncig koom nrog lawv lub zog li cas. Tej zaum nws yuav siv cov ua txheej txheej khaws cov ntsiab lus thiab qhia txog kev siv lub website siv yam tsis tau txheeb xyuas tus kheej cov qhua rau Google. Cov kua nplaum tseem ceeb uas siv los ntawm Google Analytics yog khaub noom '__ga'.
Ntxiv rau kev tshaj tawm lub website siv cov txheeb cais, Google Analytics tseem tuaj yeem siv, ua ke nrog qee cov tshaj tawm advertising, los pab qhia ntau cov ntawv tshaj tawm ntawm Google cov yam ntxwv (xws li Google Search) thiab thoob plaws lub vev xaib thiab ntsuas kev sib cuam tshuam nrog kev tshaj tawm Google Cov.
Siv IP Chaw Nyob. Tus IP address yog lej lej uas yuav qhia koj lub ntaus ntawv hauv Is Taws Nem. Tej zaum peb yuav siv koj li IP thiab browser hom los pab txheeb xyuas kev siv qauv thiab kuaj teeb meem hauv lub vev xaib no thiab txhim kho cov kev pab cuam peb muab rau koj. Tab sis yog tsis muaj cov ntaub ntawv ntxiv koj tus IP address tsis txheeb xyuas koj tus kheej.
Koj Xaiv. Thaum koj nkag mus rau lub vev xaib no, peb lub ncuav qab zib raug xa mus rau koj lub vev xaib thiab muab cia rau hauv koj lub cuab yeej. Los ntawm kev siv peb lub vev xaib, koj pom zoo rau kev siv cov ncuav qab zib thiab cov thev naus laus zis zoo sib xws.
Vam tias cov ntaub ntawv saum toj no tau piav meej meej rau koj. Raws li nws tau hais dhau los, yog tias koj tsis paub meej tias koj xav tso cai lub ncuav qab zib los yog tsis, feem ntau nws muaj kev nyab xeeb dua los tso cov ncuav qab zib kom siv thaum nws cuam tshuam nrog ib qho uas koj siv hauv peb lub xaib. Txawm li cas los xij, yog tias koj tseem tab tom nrhiav kom paub cov ntaub ntawv ntxiv, tom qab ntawd tiv tauj peb ntawm email ntawm [email tiv thaiv]
Cov khoom qab zib nruj tsim nyog yuav tsum tau qhib txhua lub sijhawm kom peb tuaj yeem txuag koj cov kev nyiam rau cov khoom qab zib.
Yog tias koj kaw cov khaub noom no, peb yuav tsis tuaj yeem txuag koj cov kev nyiam. Qhov no txhais tau tias txhua zaus koj mus ntsib lub vev xaib no koj yuav tsum muaj peev xwm qhib los yog lov tes taw ib zaug ntxiv.
Lub sij hawm tshaj tawm: Plaub Hlis-18-2020