Iyo Covid-19, kana imwe inozivikanwa se2019-nCoV kana SARS-CoV-2 hutachiona, ndeyemhuri yeCoronavirus. Sezvo SARS-CoV-2 iri yeiyo genus Coronavirus yakabatana zvakanyanya neMERS-CoV uye SARS-CoV - ayo anonziwo anokonzera zviratidzo zvakakomba zvemabayo mumaronda apfuura. Maumbirwo e2019-nCoV akaratidzirwa uye akaburitswa. [I] [ii] Mapuroteni makuru muutachiona uhwu neaya akamboonekwa muSARS-CoV kana MERS-CoV anoratidza kufanana kukuru pakati pawo.
Hutsva hweiri dambudziko rehutachiona hunoreva kuti pane kusava nechokwadi kwakawanda kwakakomberedza hunhu hwayo, nekudaro kwayedza kuti tione kana miti yemakwenzi kana makomponi anogona kubatsira munharaunda seprophylactic vamiririri kana zvinhu zvakakodzera mumishonga inorwisa-coronavirus inopesana neCovid. -19. Nekudaro, nekuda kweiyo Covid-19 kufanana kwakanyanya neakafanotaurwa maSARS-CoV uye maMERS-CoV mavairasi, yakamboburitswa tsvagiridzo yemakwenzi emakwenzi, ayo akaratidzirwa kuve anoshandisa anti-coronavirus mhedzisiro, inogona kuve yakakosha gwara rekutsvaga anti-coronavirus miti yemiriwo, inogona kunge ichirwisa hutachiona hweSARS-CoV-2.
Mushure mekuparara kweSARS-CoV, yakatanga kutaurwa kutanga kwa2003 [iii], vesaenzi vanga vachiedza nesimba kushandisa makemikari anoverengeka ehutachiona kurwisa SARS-CoV. Izvi zvakange zvave kutungamira boka renyanzvi muChina kuti riongorore zvinopfuura mazana maviri maChinese ekurapa mishonga yemakwenzi yezve antiviral zviitiko zvinopesana neiyi coronavirus strain.
Pakati peizvi, zvikamu zvina zvakaratidza zvine mwero kune zvine simba zvinodzivirira zvinopesana neSARS-CoV - Lycoris radiata (Red Spider Lily), Pyrrosia lingua (fern), Artemisia annua (Chinovava chinotapira) uye Lindera aggregate (inonhuhwirira inogara iri girini shrub nhengo yemhuri yaLaurel ). Iwo antiviral mhedzisiro yeaya aive madosi anoenderana uye akaenzana kubva pakadzika kuwanda kwechibodzwa kusvika kumusoro, zvichisiyana pane imwe neimwe yemakwenzi. Kunyanya Lycoris radiata yakaratidza chakasimba zvikuru kurwisa hutachiona. [Iv]
Mhedzisiro iyi yaienderana neyemamwe mapoka maviri ekutsvagisa, ayo akataura kuti nzvimbo inoshanda iri mumidzi yeLicorice, Glycyrrhizin, yakaratidzirwa kuve ine anti-SARS-CoV chiitiko nekudzivisa kudzokororwa kwayo. kudzidza, Glycyrrhizin yakaratidzawo antiviral chiitiko payakaedzwa yayo in vitro antiviral mhedzisiro pane gumi akasiyana emakiriniki ari oga eSARS coronavirus. Baicalin - chinoumba chirimwa Scuttelaria baicalensis (Skullcap) - yakaedzwawo muchidzidzo ichi pasi pemamiriro akafanana uye yaratidzawo chiito cheantivirioni kurwisa SARS coronavirus. [Vii] Baicalin yakaratidzirwawo kuti inodzivisa kudzokororwa kweHIV -1 hutachiona mu vitro muzvidzidzo zvakapfuura. [Viii] [ix] Zvisinei zvinofanirwa kucherechedzwa kuti in vitro zvakawanikwa zvinogona kusabatana ne in vivo kiriniki inoshanda. Izvi zvinodaro nekuti muyero wemumuromo weava vamiririri muvanhu ungasakwanise kuwana serum yekumanikidza yakafanana neyakaedzwa mu vitro.
Lycorine yakaratidza zvakare simba rekurwisa hutachiona kurwisa SARS-CoV.3 Mishumo yakati wandei yapfuura inoratidza kuti Lycorine inoita kunge iine zviitiko zvakawandisa zvehutachiona uye inonzi yakaratidza chiitiko chekudzivirira hutachiona hweHerpes Simplex (mhando I) [x] uye Poliomyelitis utachiona zvakare. [xi]
"Mimwe miriwo yakanzi yakaratidza hutachiona husingaenzaniswi neSARS-CoV iLonicera japonica (ChiJapanese Honeysuckle) nemuti unonyanya kuzivikanwa weEucalyptus, uye Panax ginseng (mudzi) kuburikidza nechinhu chayo chinoshanda Ginsenoside-Rb1." [Xii]
Humbowo kubva kuongororo dzataurwa pamusoro apa nedzimwe ongororo dzinoverengeka dzepasirese dzinoratidza kuti mishonga yemakwenzi yakawanda yakaratidza zviitiko zvehutachiona kurwisa coronaviruses [xiii] [xiv] uye maitiro avo makuru anoita kunge ari kuburikidza nekudzivirirwa kwekudzokororwa kwehutachiona. [Xv] China yakashandisa zvakanyanya mishonga yechiChinese yemishonga yekurapa SARS zvinobudirira muzviitiko zvakawanda. [xvi] Zvisinei hachina humbowo hwakasimba pamusoro pekushanda kwechipatara kwevarwere vane Covid-19 vane hutachiona.
Vanogona here kutora miriwo yakadaro vangave vanogona kukwikwidza mukugadzirwa kwemishonga mitsva yemishonga yekudzivirira kana kurapwa kweSARS?
DISCLAMER: Chinyorwa ichi chakanyorerwa ruzivo chete uye haina kuitirwa kutsiva zano rehunyanzvi, kurapwa kana kurapwa. Kana iwe uchifunga kuti unogona kuve uine zviratidzo zvine chekuita nezve izvo zveCovid-19 kana chero chimwe chirwere, danaidza chiremba wako nekukasira.
[i] Zhou, P., Yang, X., Wang, X. et al., 2020. Kuputika kwemabayo kwakabatana necoronavirus nyowani yemubhedha ungangodaro. Zvisikwa 579, 270-273 (2020). https://doi.org/10.1038/s41586-020-2012-7
[ii] Andersen, KG, Rambaut, A., Lipkin, WI, Holmes, EC naGarry, RF, 2020. Kwakatangira mavambo eSARS-CoV-2. Natural Mushonga, mapeji 1-3.
[iii] CDC SARS Nguva yekupindura. Inowanikwa pa https://www.cdc.gov/about/history/sars/timeline.htm. Yakawanikwa
[iv] Li, SY, Chen, C., Zhang, HQ, Guo, HY, Wang, H., Wang, L., Zhang, X., Hua, SN, Yu, J., Xiao, PG uye Li, RS, 2005. Kuzivikanwa kwezvinhu zvakasikwa nemishonga inorwisa hutachiona inopesana neSARS-inosanganisirwa coronavirus. Ongororo yeAntiviral, 67 (1), mapeji 18-23.
[v] Cinatl, J., Morgenstem, B. naBauer, G., 2003. Glycyrrhizin, chinhu chinoshanda chemidzi ye licorice uye kudzokorora kweSARS-inosanganisirwa coronovirus. Lancet, 361 (9374), mapeji 2045-2046.
[vi] Hoever, G., Baltina, L., Michaelis, M., Kondratenko, R., Baltina, L., Tolstikov, GA, Doerr, HW naCinatl, J., 2005. SARS− Coronavirus. Chinyorwa chemishonga chemistry, 48 (4), mapeji 1256-1259.
[vii] Chen, F., Chan, KH, Jiang, Y., Kao, RYT, Lu, HT, Fan, KW, Cheng, VCC, Tsui, WHW, Hung, IFN, Lee, TSW naGuan, Y., 2004. In vitro susceptibility ye10 kiriniki yakazvimiririra yeSARS coronavirus kumakemikari akasarudzwa antiviral. Zvinyorwa zveKliniki Virology, 31 (1), mapeji 69-75.
[viii] Kitamura, K., Honda, M., Yoshizaki, H., Yamamoto, S., Nakane, H., Fukushima, M., Ono, K. naTokunaga, T., 1998. Baicalin, an inhibitor HIV-1 kugadzirwa mu vitro. Ongororo yeAntiviral, 37 (2), mapeji 131-140.
[ix] Li, BQ, Fu, T., Dongyan, Y., Mikovits, JA, Ruscetti, FW naWang, JM, 2000. Flavonoid baicalin inodzivirira hutachiona hweHIV-1 padanho rekupinda kwehutachiona. Biochemical uye biophysical research kutaurirana, 276 (2), mapeji 534-538.
[x] Renard-Nozaki, J., Kim, T., Imakura, Y., Kihara, M. naKobayashi, S., 1989. Mhedzisiro yea alkaloid yakasarudzika kubva kuAmaryllidaceae pane herpes simplex virus. Tsvagiridzo mu virology, 140, mapeji 115-128.
[xi] Ieven, M., Vlietinick, AJ, Berghe, DV, Totte, J., Dommisse, R., Esmans, E. naAlderweireldt, F., 1982. Dyara maantiviral agents. III. Isolate yealkaloids kubva Clivia miniata Regel (Amaryl-lidaceae). Zvinyorwa zveZvisikwa Zvigadzirwa, 45 (5), mapeji 564-573.
[xii] Wu, CY, Jan, JT, Ma, SH, Kuo, CJ, Juan, HF, Cheng, YSE, Hsu, HH, Huang, HC, Wu, D., Brik, A. naLiang, FS, 2004 Mamorekuru madiki anotarisana neakanyanya kufema kufema chirwere chevanhu coronavirus. Kuenderera kweNational Academy yeSainzi, 101 (27), mapeji 10012-10017.
[xiii] Wen, CC, Kuo, YH, Jan, JT, Liang, PH, Wang, SY, Liu, HG, Lee, CK, Chang, ST, Kuo, CJ, Lee, SS uye Hou, CC, 2007. chirimwa terpenoids uye lignoids vane masimba ane simba ekurwisa hutachiona anorwisa zvakakomba zvakanyanya kufema chirwere coronavirus. Zvinyorwa zvemushonga kemesitiri, 50 (17), mapeji 4087-4095.
[xiv] McCutcheon, AR, Roberts, TE, Gibbons, E., Ellis, SM, Babiuk, LA, Hancock, REW uye Towers, GHN, 1995. Kuongororwa kweAntiviral kweBritish Columbian mishonga yekurapa. Zvinyorwa zveEthnopharmacology, 49 (2), mapeji 101-110.
[xv] Jassim, SAA naNaji, MA, 2003. Novel antiviral agents: chimiro chemushonga wemushonga. Zvinyorwa zveakaiswa microbiology, 95 (3), mapeji 412-427.
[xvi] Luo, H., Tang, QL, Shang, YX, Liang, SB, Yang, M., Robinson, N. naLiu, JP, 2020. Mishonga yechiChinese ingashandiswa kudzivirira chirwere checorona virus 2019 (COVID -19)? Kuongororwa kwezvakaitika kare zvekare, humbowo hwekutsvagisa uye zvirongwa zvezvino zvekudzivirira. Chinese Chinyorwa cheKubatanidza Mushonga, mapeji 1-8.
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Post nguva: Kubvumbi-18-2020