Covid-19, ama waxa kale oo loo yaqaan fayraska '2019-nCoV' ama 'SARS-CoV-2', waxaa iska leh qoyska Coronavirus. Maaddaama SARS-CoV-2 ay ka tirsan tahay β hiddo-wadaha Coronavirus wuxuu xiriir dhow la leeyahay MERS-CoV iyo SARS-CoV - kuwaas oo sidoo kale lagu soo warramey inay sababayaan astaamo daran oof-wareen cudur hore. Qaab dhismeedka hidde-sidaha ee 2019-nCoV waa lagu sifeeyay lana daabacay. [I] [ii] Borotiinnada ugu waaweyn ee ku jira fayraskan iyo kuwii horay loogu aqoonsaday SARS-CoV ama MERS-CoV waxay muujinayaan isu ekaansho sare oo u dhexeeya.
Waxyaabaha cusub ee noocan ah ee fayrasku waxay ka dhigan tahay inay jiraan waxyaabo badan oo aan la hubin oo ku xeeran dabeecaddiisa, sidaa darteed waa xilli hore in la go'aamiyo in dhirta dhirta ama isku-darka ay dhab ahaantii gacan ka geysan karaan bulshada sida wakiilo kahortaga ama walxaha ku habboon daawooyinka ka hortagga coronavirus ee ka dhanka ah -19. Si kastaba ha noqotee, isku xirnaanta sare ee Covid-19 ay la mid tahay fayrasyada SARS-CoV iyo MERS-CoV ee horay loo soo sheegay, cilmi baaris hore oo la daabacay oo ku saabsan xeryaha dhirta, oo lagu caddeeyay inay ku lug leeyihiin saameynta anti-coronavirus, waxay noqon kartaa hage qiimo leh oo lagu helo anti-coronavirus dhirta dhirta, oo laga yaabo inay firfircoonaan kahortagaan fayraska SARS-CoV-2.
Ka dib markii ay jabtay SARS-CoV, oo markii ugu horreysay la soo sheegay horaantii 2003 [iii], saynisyahannadu waxay si xoog leh isugu dayayeen inay ka faa'iidaystaan dhowr xeryood oo ka hortagga fayraska ah oo ka dhan ah SARS-CoV. Tani waxay u horseeday koox khubaro ah oo ku sugan Shiinaha inay soo baaraan in ka badan 200 oo ah geedaha dawada ee Shiinaha ee loogu talagalay waxqabadyada ka hortagga fayraska ee looga hortago dhibaatadan coronavirus.
Kuwaas waxaa ka mid ah, afar waxyaalood oo soosaaray ayaa muujiyey saameyn dhexdhexaad ah oo xoog leh oo ka dhan ah SARS-CoV - Lycoris radiata (Red Spider Lily), Pyrrosia lingua (a fern), Artemisia annua (Macmacaanka macaan) iyo xubinta Lindera (xubin geed cagaaran oo cagaaran oo cagaaran) ). Saamaynta fayraska ee kuwan ka mid ahi waxay ahayd mid ku tiirsan qiyaasta waxayna u dhaxeysay heerar hooseeya ee soo-saarista illaa heer sare, oo ku kala duwan soosaar kasta oo geedo ah. Gaar ahaan Lycoris radiata waxay soo bandhigtay waxqabadka ugu badan ee ka hortagga fayraska ee looga hortago culeyska feyraska. [Iv]
Natiijadani waxay la jaanqaadaysay tan laba kooxood oo kale oo cilmi-baadhiseed ah, oo soo jeediyay in qayb firfircoon oo ka kooban xididdada Licorice, Glycyrrhizin, la caddeeyay inay leedahay wax-ka-hortagga SARS-CoV iyada oo la joojinayo soo-saarkeeda. [V] [vi] Mid kale daraasad, Glycyrrhizin ayaa sidoo kale soo bandhigtay waxqabadka fayraska markii la baaray saamaynta ay ku leedahay faytarka fayraska ee ku saabsan 10 go'doominno caafimaad oo kala duwan oo ah SARS coronavirus. Baicalin - wuxuu ka tirsan yahay warshadda Scuttelaria baicalensis (Skullcap) - sidoo kale waxaa lagu tijaabiyey daraasaddan isla xaaladahaas isla markaana wuxuu muujiyey tallaabo ka hortag ah oo ka dhan ah SARS coronavirus. -1 virus in vitro daraasadihii hore. [Viii] [ix] Si kastaba ha noqotee waa in la ogaadaa in baaritaanka fitamiinada uusan xiriir la yeelan karin wax ku oolnimada daaweynta vivo. Tani waa sababta oo ah qiyaasta afka ee wakiiladan bani'aadamka laga yaabo inaysan gaarin isku-uruurinta dhiigga ee dhiigga oo la mid ah tan lagu tijaabiyay faytarka.
Lycorine ayaa sidoo kale muujisay tallaabo xoog leh oo ka hortagga fayraska ah oo ka dhan ah SARS-CoV.3 Warbixinno dhowr ah oo hore ayaa sheegaya in Lycorine ay u muuqato inay leedahay waxqabadyo fara badan oo ka hortagga fayraska ah waxaana lagu soo warramey inay muujisay tallaabo ka hortag ah oo ku saabsan fayraska Herpes Simplex (nooca I) [x] iyo Polioyelitis sidoo kale fayraska. [xi]
"Dhirta kale ee la soo sheegay inay muujisay waxqabadka fayraska ee ka dhanka ah SARS-CoV waa Lonicera japonica (Japanese Honeysuckle) iyo dhirta caanka ah ee loo yaqaan 'Eucalyptus plant', iyo Panax ginseng (xidid) iyada oo loo marayo qeybteeda firfircoon ee Ginsenoside-Rb1." [Xii]
Caddaymaha ka soo baxay daraasadaha kor lagu soo sheegay iyo daraasado kale oo badan oo adduunka ah ayaa sheegaya in dawooyin badan oo ka kooban dhirta ay soo bandhigeen waxqabadyo ka hortag ah oo ka dhan ah coronaviruses [xiii] [xiv] iyo habka ugu weyn ee ficilkoodu u muuqdo inuu yahay iyada oo loo marayo ka hortagga faafida fayraska. ayaa si baaxad leh u isticmaashay geedo dhaqameedka shiinaha si loogu daaweeyo SARS xaalado badan si wax ku ool ah.
Soosaarka dhirta noocan oo kale ah mala noqon karaa musharraxiin suuragal u ah soo saarista dawooyinka cusub ee fayraska looga hortago ama lagu daweeyo SARS?
DISCLAMER: Maqaalkan waxaa loo qoray ujeedooyin macluumaad oo keliya mana loogu talagalin in lagu beddelo talobixin caafimaad, baaritaan ama daaweyn xirfad leh. Haddii aad u malaynayso inaad leedahay calaamado la xiriira kuwa loo yaqaan 'Covid-19' ama cudur kasta oo kale, isla markiiba wac dhakhtarkaaga.
[i] Zhou, P., Yang, X., Wang, X. et al., 2020. Cudurka oof-wareenka oo dillaaca oo la xiriira coronavirus cusub oo asal ahaan ka soo jeeda fiidmeerta. Dabeecadda 579, 270-273 (2020). https://doi.org/10.1038/s41586-020-2012-7
[ii] Andersen, KG, Rambaut, A., Lipkin, WI, Holmes, EC iyo Garry, RF, 2020. Asalka ugu dhow ee SARS-CoV-2. Daawada Dabeecadda, pp.1-3.
[iii] Jadwalka Jawaabta CDC SARS. Waxaa laga heli karaa https://www.cdc.gov/about/history/sars/timeline.htm. La helay
[iv] Li, SY, Chen, C., Zhang, HQ, Guo, HY, Wang, H., Wang, L., Zhang, X., Hua, SN, Yu, J., Xiao, PG iyo Li, RS, 2005. Aqoonsiga xeryahooda dabiiciga ah ee leh waxqabadyada fayraska ee ka dhanka ah coronavirus-ka la xiriira SARS. Cilmi-baarista fayraska, 67 (1), pp.18-23.
[v] Cinatl, J., Morgenstem, B. iyo Bauer, G., 2003. Glycyrrhizin, oo ah qayb firfircoon oo ka mid ah xididdada licorice-ka iyo soo-saarista SARS ee la xiriirta coronovirus. Lancet, 361 (9374), pp.2045-2046.
[vi] Hoever, G., Baltina, L., Michaelis, M., Kondratenko, R., Baltina, L., Tolstikov, GA, Doerr, HW iyo Cinatl, J., 2005. Waxqabadka ka hortagga fayraska ee Glycyrrhizic Acid Derivatives SARS− Coronavirus. Joornaalka kiimikada daawada, 48 (4), pp.1256-1259.
[vii] Chen, F., Chan, KH, Jiang, Y., Kao, RYT, Lu, HT, Fan, KW, Cheng, VCC, Tsui, WHW, Hung, IFN, Lee, TSW iyo Guan, Y., 2004. U nuglaanta fitamiinada 10 keli keli kiliinikada ee SARS coronavirus si loo xusho xeryahooda antiviral. Joornaalka Daaweynta Virology, 31 (1), pp.69-75.
[viii] Kitamura, K., Honda, M., Yoshizaki, H., Yamamoto, S., Nakane, H., Fukushima, M., Ono, K. iyo Tokunaga, T., 1998. Baicalin, oo ah kahortaga Wax soo saarka HIV-1 ee faytarka. Cilmi-baarista fayraska, 37 (2), pp.131-140.
[ix] Li, BQ, Fu, T., Dongyan, Y., Mikovits, JA, Ruscetti, FW iyo Wang, JM, 2000. Flavonoid baicalin wuxuu joojiyaa infekshanka HIV-1 ee heerka gelitaanka fayraska. Isgaarsiinta cilmi-baarista bayoolaji iyo biophysical, 276 (2), pp.534-538.
[x] Renard-Nozaki, J., Kim, T., Imakura, Y., Kihara, M. iyo Kobayashi, S., 1989. Saamaynta alkaloids-ka ee laga soocay Amaryllidaceae ee fayraska herpes simplex. Cilmi-baaris ku saabsan cilmiga virology, 140, pp.115-128.
[xi] Ieven, M., Vlietinick, AJ, Berghe, DV, Totte, J., Dommisse, R., Esmans, E. iyo Alderweireldt, F., 1982. Wakiilo ka hortaga fayraska dhirta. III. Go'doominta alkaloids ka Clivia miniata Regel (Amaryl-lidaceae). Joornaalka Alaabta Dabiiciga ah, 45 (5), pp.564-573.
[xii] Wu, CY, Jan, JT, Ma, SH, Kuo, CJ, Juan, HF, Cheng, YSE, Hsu, HH, Huang, HC, Wu, D., Brik, A. iyo Liang, FS, 2004 Molekuyuleellada yaryar ee beegsanaya cilladda neefsashada daran ee daran ee loo yaqaan 'coronavirus human'. Talaabooyinka Akadeemiyada Qaranka ee Sayniska, 101 (27), pp.10012-10017.
[xiii] Wen, CC, Kuo, YH, Jan, JT, Liang, PH, Wang, SY, Liu, HG, Lee, CK, Chang, ST, Kuo, CJ, Lee, SS iyo Hou, CC, 2007. Gaar ah dhirta terpenoids iyo lignoids waxay leeyihiin waxqabadyo ka hortag ah oo fayras ah oo ka dhan ah coronavirus-ka daran ee neefsashada. Joornaalka kiimikada daawada, 50 (17), pp.4087-4095.
[xiv] McCutcheon, AR, Roberts, TE, Gibbons, E., Ellis, SM, Babiuk, LA, Hancock, REW iyo Towers, GHN, 1995. Baaritaanka ka hortagga fayraska ee dhirta daawada ee British Columbian. Wargeyska Ethnopharmacology, 49 (2), pp.101-110.
[xv] Jassim, SAA iyo Naji, MA, 2003. Novel wakiilada fayraska: aragtida dhirta daawada. Joornaalka jimicsiga lagu dabaqay, 95 (3), pp.412-427.
. -19)? Dib-u-eegis ku saabsan classics taariikheed, caddaynta cilmi-baarista iyo barnaamijyada ka-hortagga hadda. Joornaalka Shiinaha ee Daaweynta Isku-dhafan, pp.1-8.
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Waqtiga boostada: Abriil-18-2020