Beta-nicotinamide Mononucleotide (nMn), inogadzirwa NAMPT kuita uye kiyi ZWL + zvenguva, ameliorates shuga kusashivirira kuburikidza pakudzorera ZWL + nhanho muna HFD Kutemeswa T2D mbeva. NMn hunowedzerawo hepatic jekiseni nehanya pavezve Gene okuti chokuita oxidative kushushikana, anogumbura mhinduro, uye Ritmos mutinhimira, pamwe kuburikidza SIRT1 activation. NMn rinoshandiswa kuti kudzidza kunyorerana motifs mukati RNA aptamers uye ribozyme activation pezvakaitwa chokuita β-nicotinamide mononucleotide (Beta-nMn) -activated RNA zvimedu.
Nicotinamide mononucleotide ( "nMn" uye "β-nMn") riri nucleotide zvinobva ribose uye nicotinamide. Niacinamide (nicotinamide,) inzira vhitamini B3 (niacin.) Sezvo nokukanganisika aizotangira pamusoro ZWL +, zvingava zvinobatsira mune kudzivirira pellagra.
Its unconcentrated chimiro, niacin, unowanikwa zvakasiyana muviri manyuko: nzungu, Mushrooms (portobello, grilled), makotapeya, Green Peas (itsva), uye vamwe hove uye mhuka zvikafu.
Muzvidzidzo [iri mbeva], nMn akaratidza kuti achinje zera-chokuita arterial dysfunction kuburikidza kudzikira oxidative mupfungwa.
Name: Beta-Nicotinamide Mononucleotide
CAS #: 1094-61-7
Product zita: Beta-Nicotinamide Mononucleotide; nMn
Other zita: β-D-nMn; BETA-nMn; Beta-D-nMn; nMn zwitterion; Nicotinamide Ribotide; Nicotinamide nucleotide; Nicotimide mononucleotide; Nicotinamide mononuclotide
CAS: 1094-61-7
Molecular fomura: C11H15N2O8P
Molecular Weight: 334,22
Chakachena: 98%
Storage Temperature: 2-8 ° C
Chitarisiko: White upfu
Use: Anti-zvokukwegura
basa:
1.Nicotinamide mononucleotide mumasero dzevanhu basa rinokosha mune simba pazera, akavarambidza mu intracellular ZWL (nicotinamide adenine dinucleotide, sero simba kutendeuka inokosha coenzyme) kwetunhu, rakashandiswa Anti kukwegura, achawira ropa shuga uye nezvimwe zvoutano zvigadzirwa.
2. Nicotinamide Mononucleotide iri mvura-soluble vhitamini, The chigadzirwa iri chena crystalline upfu, odorless kana zvinenge odorless, shungu kuravira, pachena soluble mumvura kana panyaya iyi, dissolvable mu glycerin.
3.Nicotinamide Mononucleotide zviri nyore kupinza nemumuromo, uye zvinogona rinoparadzirwa mumuviri, zvakawandisa metabolites kana kumumvuri nokukurumidza dzingai kubva weti. Nicotinamide chikamu coenzyme I uye coenzyme II, anoridza basa rehydrogen hurukuro mune chaivo oxidation kufema cheni, anogona kusimudzira zvoutachiona oxidation pezvakaitwa uye zvinyama muviri, kuramba zvakajairika zvinyama (kunyanya ganda, zvomudumbu turakiti uye tsinga) kuvimbika ane basa rinokosha .
Uyezve, nicotinamide ane kudzivirira uye kurapwa nomwoyo mufurati, sinus raiva pedyo nebundu nerevane Anti-yokutsanya experimental arrhythmias, nicotinamide anogona yekudyidzana kuvandudza mwoyo mwero uye atrioventricular misa anokonzerwa verapamil.
