Beta-nicotinamide Mononucleotide (NMN), umkhiqizo ukusabela NAMPT kanye nad isihluthulelo + Lesisemkhatsini, ameliorates ukungabekezelelani glucose ngokubenza baphinde nad + amazinga e HFD olubangelwa T2D amagundane. NMN sijulisa hepatic insulini ukuzwela futhi ubuyisela isakhi sofuzo Inkulumo ezihlobene nokucindezeleka oxidative, impendulo ukuvuvukala, futhi isigqi lomzimba, ngokwengxenye ngokusebenzisa SIRT1 kusebenze. NMN isetshenziselwa ukutadisha Motifs esibophezelayo phakathi RNA aptamers futhi ribozyme kusebenze izinqubo ezihilela β-nicotinamide mononucleotide (Beta-NMN) -activated RNA izinsalela.
Mononucleotide Nicotinamide ( "NMN" futhi "β-NMN") iyinhlangano nucleotide ethathwe ribose futhi nicotinamide. Niacinamide (nicotinamide,) kuwuhlobo Vitamin B3 (niacin.) Njengoba eyandulela kwamakhemikhali nad +, kungase kube usizo ekuvimbeleni pellagra.
Igama layo lesi-unconcentrated, niacin, itholakala kwimithombo ehlukahlukene lwethu lokudla okunempilo: Amantongomane, Amakhowe (portobello, eyosiwe), Ukwatapheya, Peas Green (fresh), futhi othile izinhlanzi nezilwane inyama.
Ezifundweni [ku amagundane], NMN asibonise ukuhlanekezela ezihlobene nokukhula lwemithambo ukungasebenzi ngokunciphisa inani ukucindezeleka oxidative.
Name: Beta-Nicotinamide Mononucleotide
CAS #: 1094-61-7
Igama lomkhiqizo: Beta-Nicotinamide Mononucleotide; NMN
Okunye igama: β-D-NMN; BETA-NMN; beta-D-NMN; NMN zwitterion; Nicotinamide Ribotide; Nicotinamide nucleotide; Nicotimide mononucleotide; Nicotinamide mononuclotide
CAS: 1094-61-7
Yamamolekhula ifomula: C11H15N2O8P
Yamamolekhula isisindo: 334,22
Uhlanzekile: 98%
Isitoreji lokushisa: 2-8 ° C
Ukubukeka: White powder
Sebenzisa: anti-ukuguga
umsebenzi:
1.Nicotinamide mononucleotide e amangqamuzana omuntu ukudlala indima ebalulekile amandla isizukulwane, kwakuhilela e nad intracellular (nicotinamide adenine ihambisane dinucleotide, iseli energy conversion coenzyme ezibalulekile) zamagama, elisetshenziswa anti-ukuguga, iwe kashukela kanye neminye imikhiqizo ukunakekelwa kwezempilo.
2. Nicotinamide Mononucleotide kuyinto uvithamini amanzi-encibilikayo, Umkhiqizo crystalline ezimhlophe powder, ayinaphunga noma cishe ayinaphunga okwakumunyu ukunambitheka, encibilikayo ngokukhululekile emanzini noma ethanol, dissolvable e glycerin.
3.Nicotinamide Mononucleotide Kulula ukuncela zemibuzo nezimpendulo kabanzi ingasatshalaliswa emzimbeni, i-metabolites ngokweqile noma prototype ngokushesha saxosha kusukela umchamo. Nicotinamide kuyingxenye coenzyme mina coenzyme II, udlala indima hydrogen kwezidingo begazi namachibi uchungechunge zokuphefumula, ongakwazi ukukukhuthaza begazi namachibi izinqubo nezicubu umzimba, silondoloze izicubu evamile (ikakhulukazi esikhumbeni, ipheshana yesisu nesimiso sezinzwa) ubuqotho unendima ebalulekile .
Ngaphezu kwalokho, nicotinamide has nokwelashwa inhliziyo block, umsebenzi itheku node anti-okusheshayo arrhythmias zokuhlola, nicotinamide kungaba ngokuphawulekayo ngcono ukushaya kwenhliziyo block atrioventricular kubangelwa verapamil.
