Beta-nicotinamide Mononucleotide (NMN), sehlahisoa sa NAMPT itšoara joang le nad senotlolo + lipakeng, ameliorates tsoekere mamellane ka tsosolosa nad + maemo ka litoeba HFD-hlohlelletsoa T2D. NMN hape kgothaletsa e amanang le sebete ka insulin nahanela le tsosolosa phatsa ea lefutso poleloana ee e amanang le ho imeloa kelellong oxidative, a hlabang le karabelo, 'me morethetho circadian, karolo e' ngoe ka SIRT1 Tshebediso ya. NMN e sebediswa bakeng sa ho ithuta motifs tlamme ka hare aptamers RNA le dithulaganyo ribozyme Tshebediso ya amang β-nicotinamide mononucleotide (Beta-NMN) -activated RNA lingoathoana.
Nicotinamide mononucleotide ( "NMN" le "β-NMN") ke nucleotide tswang ribose le nicotinamide. Niacinamide (nicotinamide,) ke mofuta o mong oa vithamine ea B3 (niacin.) Ha e le selelekela skeletal tsa nad +, ho ka ba molemo ka ho thibela pellagra.
Foromo lona unconcentrated, niacin, e fumanoa mefuta e fapaneng ya mehloli phepo e nepahetseng: matokomane, li-mushroom (Portobello, halikiloeng), kha li-avocado, Green dierekisi (a hloekileng), 'me tse ling litlhapi le phoofolo nama.
Ka lithuto tsa [ka litoeba], NMN o bontšitse ho kgutlisetsa morao lilemo tse amanang ea bohlokoa ho se sebetse ka ho fokotseha khatello ea kelello oxidative.
Name: Beta-Nicotinamide Mononucleotide
CAS #: 1094-61-7
Product name: Beta-Nicotinamide Mononucleotide；NMN
Other name: β-D-NMN; beta-NMN; beta-D-NMN; NMN zwitterion; Nicotinamide Ribotide; Nicotinamide nucleotide; Nicotimide mononucleotide; Nicotinamide mononuclotide
CAS: 1094-61-7
limolek'hule moralo: C11H15N2O8P
limolek'hule Weight: 334,22
Hloekileng: 98%
Storage Mocheso: 2-8 ° C
Ponahalo: phofo White
Sebelisa:-ba khahlanong le botsofali
Function:
1.Nicotinamide mononucleotide liseleng batho phetha karolo ea bohlokoa ka ho isa molokong o mong matla, e ka setotsoana intracellular nad (nicotinamide adenine dinucleotide, matla a ka cell ho sokoloha bohlokoa coenzyme) tswakana, sebelisoa ka-ba khahlanong le botsofali, a oa mali tsoekere le lihlahisoa tse ling tlhokomelo ea bophelo.
2. Nicotinamide Mononucleotide ke metsi-qhibilihang ka har'a vithamine, sehlahiswa The e tšoeu bonaletsang phofo, odorless kapa hoo e ka bang odorless, e babang ka tatso, bolokolohi qhibilihang ka har'a ka metsi kapa ethanol, dissolvable ka glycerin.
3.Nicotinamide Mononucleotide ke ho le bonolo ho monya molomo, 'me ka e abuoeng ka' mele, ho metabolites feteletseng kapa mochine o ka potlako leleka ho tloha moroto. Nicotinamide ke karolo ea coenzyme ke le coenzyme II, o phetha karolo ea pelehi hydrogen ka likokoana-hloko ho kena moea ho hema ketane, ka ho kgothaletsa dithulaganyo tsa likokoana-hloko ho kena moea le metabolism dinama tse nyenyane tse, ho boloka lisele tloaelehile (haholo-holo ea letlalo, pampitšana tshilong ya dijo le tsamaiso ea methapo) botšepehi ba na le karolo ea bohlokoa .
Ho phaella moo, nicotinamide na thibelo le kalafo ea le literata pelo, mosebetsi sinus noute le-ba khahlanong le hore ba itime lijo liteko arrhythmias, nicotinamide ka haholo ntlafatsa ho otla ha pelo le ea le literata atrioventricular bakoang ke verapamil.
