Beta-nicotinamide Mononucleotide (NMN), yimveliso indlela NAMPT kunye nad isitshixo + esiphakathi, ameliorates ukunyamezelana iswekile ngokubuyisela nad + amanqanaba mpuku T2D HFD-uqhutyelwe. NMN kwakhona siphucula hepatic insulin ubuntununtunu kwaye ibuyisela ibinzana gene ezinxulumene noxinzelelo oxidative, impendulo kwiintetho ezikralayo, nesingqisho lomzimba, ngokuyinxenye ngenxa SIRT1 lusebenze. NMN isetyenziswa ukufunda mibala ezibophelelayo ngaphakathi aptamers RNA kunye neenkqubo ribozyme lokuvula ebandakanya mononucleotide β-nicotinamide (Beta-NMN) iziqwenga RNA -activated.
Mononucleotide Nicotinamide ( "NMN" yaye "β-NMN") i nucleotide ezivela ribose kunye nicotinamide. Niacinamide (nicotinamide) luhlobo ivithamin B3 (niacin.) Njengoko njengomanduleli zengqo- ka nad +, kusenokuba luncedo ekuthinteleni pellagra.
Ifomu yayo unconcentrated, niacin, ifumaneka kwiintlobo ngeentlobo zemithombo zesondlo: namandongomane, Mushrooms (portobello, eqhotsiweyo), ii-avokhado, Peas Green (fresh), kunye inyama ezithile intlanzi kunye nezilwanyana.
Xa izifundo [kwi mpuku], NMN lubonise ukuba umva ezinxulumene-yobudala esimbaxa kwekhono ngokunciphisa ntshikilelo oxidative.
Name: Beta-Nicotinamide Mononucleotide
CAS #: 1094-61-7
Igama Product: Beta-Nicotinamide Mononucleotide; NMN
Okunye Igama: β-D-NMN; BETA-NMN; beta-D-NMN; NMN zwitterion-Nicotinamide Ribotide-Nicotinamide nucleotide-Nicotimide mononucleotide; Nicotinamide mononuclotide
CAS: 1094-61-7
Ezinto ifomula: C11H15N2O8P
ezinto Ubunzima: 334,22
Purity: 98%
Storage lobushushu: 2-8 ° C
Inkangeleko: White powder
Sebenzisa: anti-nokuguga
umsebenzi:
1.Nicotinamide mononucleotide kwiiseli zabantu zidlala indima ebalulekileyo isizukulwana amandla, kodwa ukubandakanyeka nad intracellular (nicotinamide adenine dinucleotide, ukuguqulwa energy iseli coenzyme ebalulekileyo) yokuqaphela, esetyenziswa kwi anti-ukwaluphala, niwe iswekile yegazi kunye nezinye iimveliso zokhathalelo lwempilo.
2. Nicotinamide Mononucleotide i vitamin ngamanzi-enyibilikayo, Le imveliso powder emhlophe crystalline, esha okanye phantse ayinavumba, ukrakra incasa, ezinyibilikayo ngokukhululekileyo emanzini okanye ethanol, dissolvable in glycerin.
3.Nicotinamide Mononucleotide kulula ukuba simunce zomlomo, kwaye zisasazwa emzimbeni, le metabolites kwemfuneko okanye ngere- ngokukhawuleza ukukhupha ukusuka nomchamo. Nicotinamide yinxalenye coenzyme mna coenzyme II, udlala indima yokuba unikezelo hydrogen eziphilayo igcwala chain yokuphefumla, uyakwazi ukukhuthaza iinkqubo igcwala eziphilayo kunye izihlunu umzimba, ukugcina izicwili yesiqhelo (ingakumbi eluswini, wokugaya kunye luvo) ingqibelelo unendima ebalulekileyo .
Ukongeza, nicotinamide uye nokuthintela kunye nokunyanga block intliziyo, umsebenzi sinus esiludumbo kunye arrhythmias anti-fast yokulinga, nicotinamide unako kakhulu ngcono izinga lentliziyo kunye block atrioventricular okubangelwa verapamil.
