Nicotinamide mononucleotide /NMN
Beta-nicotinamide Mononucleotide (NMN), a product of the NAMPT reaction and a key NAD+ intermediate, ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. NMN also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation. NMN is used for studying binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (Beta-NMN)-activated RNA fragments.
Nicotinamide mononucleotide (“NMN” and “β-NMN”) is a nucleotide derived from ribose and nicotinamide. Niacinamide (nicotinamide,) is a form of vitamin B3 (niacin.) As a biochemical precursor of NAD+, it may be useful in the prevention of pellagra.
Its unconcentrated form, niacin, is found in a variety of nutritional sources: Peanuts, Mushrooms (portobello, grilled), Avocados, Green Peas (fresh), and certain fish and animal meats.
In studies [on mice], NMN has shown to reverse age-related arterial dysfunction by decreasing oxidative stress.
Name: Beta-Nicotinamide Mononucleotide
CAS ＃: 1094-61-7
Product name: Beta-Nicotinamide Mononucleotide；NMN
Other name:β-D-NMN;BETA-NMN;beta-D-NMN;NMN zwitterion;Nicotinamide Ribotide;Nicotinamide nucleotide;Nicotimide mononucleotide;Nicotinamide mononuclotide
Molecular formula: C11H15N2O8P
Molecular Weight: 334.22
Storage Temperature: 2-8°C
Appearance: White powder
1.Nicotinamide mononucleotide in human cells play an important role in energy generation, it involved in intracellular NAD (nicotinamide adenine dinucleotide, cell energy conversion important coenzyme) synthesis, used in anti-aging, fall blood sugar and other health care products.
2. Nicotinamide Mononucleotide is a water-soluble vitamin, The product is white crystalline powder, odorless or nearly odorless, bitter in taste, freely soluble in water or ethanol, dissolvable in glycerin.
3.Nicotinamide Mononucleotide is easy to absorb oral, and can be widely distributed in the body, the excess metabolites or prototype quickly expel from urine. Nicotinamide is part of coenzyme I and coenzyme II, plays the role of hydrogen delivery in biological oxidation respiratory chain, can promote biological oxidation processes and tissue metabolism, maintain normal tissue (especially the skin, digestive tract and nervous system) integrity has an important role.
In addition, nicotinamide has prevention and treatment of heart block, sinus node function and anti-fast experimental arrhythmias, nicotinamide can significantly improve the heart rate and atrioventricular block caused by verapamil.