Sialic Acid Powder

Sialic acid (SA), scientifically known as “N-acetylneuraminic acid,” is a naturally occurring carbohydrate. It was originally isolated from the submandibular gland mucin, hence the name. Sialic acid is usually present in the form of oligosaccharides, glycolipids or glycoproteins. In the human body, the brain has the highest sialic acid content. The sialic acid content in the gray matter is 15 times that of the internal organs such as liver and lung. The main food source of sialic acid is breast milk, which is also found in milk, eggs and cheese.

In medicine, glycolipids containing sialic acid are called gangliosides, which play a very important role in the production and development of the brain and nervous system. At the same time, animal studies have shown that the reduction of ganglioside levels is associated with early malnutrition and reduced learning ability, while supplementation with sialic acid can improve animal learning behavior. Adequate supply of sialic acid may be particularly important for the normal development of brain function in children with low birth weight. After the baby is born, the sialic acid in the breast milk is essential to ensure their normal development. Investigations have shown that sialic acid levels in mothers after childbirth decline over time. Therefore, continuous intake of sufficient amount of sialic acid during pregnancy and after pregnancy can help maintain sialic acid levels in the body. Moreover, the content of sialic acid is also significantly correlated with the content of DHA, suggesting that it is highly likely to be associated with brain structure and brain function development in infants, both of which may be beneficial for early brain development.

Studies have shown that the golden period of human brain development is between the ages of 2 and 2 years of age. This stage is a critical period for brain cell number adjustment, volume increase, functional perfection, and neural network formation. Therefore, smart mothers will naturally pay attention to the intake of sufficient amount of sialic acid during pregnancy. After the baby is born, breast milk is an effective way to add sialic acid to the baby, because about 0.3-1.5 mg of sialic acid per milliliter of breast milk. In fact, all mammals, including humans, are able to synthesize sialic acid from the liver by themselves. However, the liver development of newborns is not yet mature, and the need for rapid growth and development of the brain may limit the synthesis of sialic acid, especially for premature infants. Therefore, sialic acid in breast milk is essential for ensuring normal growth and development of the baby.
Australian researchers have found that breast-fed infants have a higher concentration of sialic acid in the frontal cortex than formula-fed infants. This may promote the formation of synapses, help the baby’s memory to form a more stable structural basis, and strengthen the development of the nervous system.

What is Sialic acid

Sialic Acid is a group of derivatives of neuraminic acid (N- or O-substituted derivatives neuraminic acid). Usually in the form of oligosaccharides, glycolipids or glycoproteins.

Sialic Acid is also the name for this group’s most common member – N-acetylneuraminic acid (Neu5Ac or NANA).

Sialic acid family

It has been known for nearly 50 members, all derivatives of the negatively charged 9-carbon sugar neuraminic acid.

N-acetylneuraminic acid (Neu5Ac), N-glycolylneuraminic

acid (Neu5Gc) and deaminoneuraminic acid (KDN) are its core monomer.

N-acetylneuraminic acid is the only kind of Sialic Acid in our body.

Sialic Acid and Bird’s nest

Because Sialic acid is rich in bird’s nest, it is also called bird’s nest acid, which is an essential indicator of bird’s nest grading.

Sialic Acid is the main nutrition ingredients in Bird’s nest, around 3%-15% by weight.

Among all the known foods, Bird’s nest contains the highest content of Sialid acid, around 50 times higher than other foods.

1g Bird’s nest equals 40 eggs if we get the same quantity of Sialic Acid.

Sialic Acid food sources

Generally, plants contain no Sialic acid. The leading supply of Sialic acid is human milk, meat, egg, and cheese.

Contents of total Sialic acid in conventional foods (µg/g or µg/ml).

We can see that the Sialic acid in Human milk is high, which is the key ingredient for a baby’s brain development.

But Sialic Acid content is different in different Periods Human milk

Breast milk colostrum  1300 +/- 322 mg/l

10 days later    983 +/- 455 mg/l

Preterm infant milk powder    197 +/- 31 mg/l

Adapted milk formulas  190 +/- 31 mg/l

Partially adapted milk formulas 100 +/- 33 mg/l

Follow-up milk formulas 100 +/- 33 mg/l

Soy-based milk formulas 34 +/- 9 mg/l

Compared with Breast milk, Infant milk powder contains around 20% Sialic acid from Human milk, while the baby can only get 25% Sialic acid from Breast milk.

For a Preterm baby, Sialic acid is more essential than a healthy baby in Brain development.

Sialic Acid Study on Milk powder

“The results indicated that brain sialic acid content plays an important role in determining behavior. Another group observed improved learning with free sialic acid treatment in rodents.”

CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition, and Natural

Resources 2006 1, No. 018， Is sialic acid in milk food for the brain?， Bing Wang

“The Conclusion is Higher brain ganglioside and glycoprotein sialic acid concentrations in infants fed human milk suggests increased synaptogenesis and differences in neurodevelopment.”

Am J Clin Nutr 2003;78:1024–9. Printed in the USA. © 2003 American Society for Clinical Nutrition，Brain ganglioside, and glycoprotein sialic acid in breastfed compared with formula-fed infants， Bing Wang

“Neural cell membranes contain 20 times more sialic acid than other types of membranes, indicating that sialic acid has a clear role in neural structure.”

The European Journal of Clinical Nutrition, (2003) 57, 1351–1369, The role and potential of sialic acid in human nutrition, Bing Wang

N-Acetylneuraminic acid Application

Milk Powder

Currently, More and more Breastfeeding mothers’ milk powder, Babies’ Milk powder, and Nutritional supplements contain Sialic Acid on the Market.

For Breastfeeding Mothers

For Baby Milk powder 0-12 months

For Healthcare product

For Beverage

Since Sialic acid has a good water-soluble ability, many companies are trying to development Sialic acid beverages for Brain health or add into milk products.

N-Acetylneuraminic acid Safety

N-Acetylneuraminic acid is very safe. Currently, no negative news reported on Sialic acid.

The USA, China, and EU governments approve Sialic acid to be used in Food and Health care products.

USA

In 2015, N-Acetyl-D-neuraminic acid (Sialic acid) was determined Generally Recognized as Safe (GRAS)

China

In 2017, China Government approved N-Acetylneuraminic acid as a New Resource Food Ingredient.

EU

Safety of synthetic N-acetyl-d-neuraminic acid as a novel food under Regulation (EC) No 258/97

On 16 October 2015, orphan designation (EU/3/12/972) was granted by the European Commission to Ultragenyx UK Limited, United Kingdom, for sialic acid (also known as aceneuramic acid) for treatment of GNE myopathy.

Scientific Opinion on the substantiation of health claims related to sialic acid and learning and memory (ID 1594) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

Dosage

CFDA suggest 500mg/day

Novel food suggests 55mg/day for Infant and 220mg/day for Young and middle-aged women

N-acetylneuraminic acid Function

Memory and Intelligence improvement

By interacting with brain cell membranes and synapses, Sialic acid increases the response rate of synapses in the brain’s nerve cells, thereby promoting the development of memory and intelligence.

New Zealand scientists have done a series of experiments to confirm the critical role of bird’s nest acid in children’s intellectual development. Finally, the researchers concluded that supplementing bird’s nest acid in infants could increase the concentration of bird’s nest acid in the brain, thereby improving the brain’s ability to learn.

Improve intestinal absorption capacity

According to the simple physical phenomenon of the opposite sex, the positively charged minerals and some vitamins that enter the intestine are easily combined with the strong negatively charged bird’s nest acid, so the intestinal absorption of vitamins and minerals. The ability has been enhanced from it.

Promote intestinal antibacterial detoxification

Sialic Acid on the cell membrane protein plays a crucial role in improving cell recognition ability, detoxification of cholera toxin, prevention of pathological Escherichia coli infection, and regulation of blood protein half-life.

Longevity

Sialic acid has a protective and stabilizing effect on cells, and the lack of sialic acid can lead to a decrease in blood cell life and a decrease in glycoprotein metabolism.

Develop new medicine for Sialic Acid

Scientists try to treat gastrointestinal diseases with sialic acid anti-adhesion drugs. Sialic acid anti-adhesive drugs can treat Helicobacter pylori to treat gastric ulcers and duodenal ulcers.

Sialic acid is a glycoprotein. It determines the mutual recognition and binding of cells and has clinically similar anti-inflammatory effects as aspirin.

Sialic acid is a drug for central or topical neurological diseases and demyelinating diseases; sialic acid is also a cough expectorant.

Sialic acid as a raw material can develop a series of essential sugar drugs, anti-virus, anti-tumor, anti-inflammatory, and treatment of senile dementia have outstanding results.

The production process of Sialic Acid

The starting raw materials are mainly glucose, corn steep liquor,glycerinum, and magnesium sulfate. And we use fermented technology. During this process, we use the way of sterilization to keep the materials clean. Then by hydrolysis, concentration, drying, and smashing. After all the processes, we get the final product. And our QC will use HPLC to test the material quality for every batch before we deliver it to the clients.

Product Name: Sialic acid ; N-Acetylneuraminic acid

Other Name:5-Acetamido-3,5-dideoxy-D-glycero-D-galactonulosonic acid o-Sialic acid Galactononulosonic acid Lactaminic acid NANA N-Acetylsialic acid

Origin: Edible bird’s nest
Spec: 20%–98%
Appearance: white fine powder
CAS NO.: 131-48-6
MW: 309.27
MF: C11H19NO9

Place of Origin: China

Storage: Store in a cool & dry area, keep away from the direct light and heat.
Validity: Two years if properly stored.

FUNCTION:

1. Anti-virus function.
2. Anti-cancer function.
3. Anti-inflammation function.
4. Defensive function against bacteriological infectiong.
5. Controlling ability of immune system.
6. Restraining ability against pigmentation.
7. Signal transformation in nerve cells.
8. Play a key role in brain development and learning.
9. As precursor for the manufacture of many pharmaceutical drugs.