Piperlongumine ufa

Dzina la malonda:Piperlongumineufa

Dzina Lina: Piplatin, Piperlongumine Tingafinye, Piplatine, 5,6-Dihydro-1-[(2E) -1-oxo-3- (3,4,5-trimethoxyphenyl) -2-propen-1-yl] -2 (1H) -pyridinone,PPLGM, pippali ufa, Piper Longum Tingafinye

Nambala ya CAS: 20069-09-4

Gwero la Botanical: Piper Longum Linn

Chiwerengero: 98% min

Zitsanzo Zaulere: Zilipo
Maonekedwe: ufa woyera wa crystalline
Ubwino: Anti-cancer, anti-kukalamba, senolytic
Alumali Moyo: 2 years

Piperlongumine Powder| | Chiyero Chapamwamba (98%+) | CAS 20069-09-4 | Kugwiritsa Ntchito Kafukufuku

Zowonetsa Zamalonda
Piperlongumine (Piplatine), alkaloid ya bioactive yochokera kuPiper longumplant, ndi mankhwala achilengedwe omwe ali ndi mankhwala oletsa khansa. Imapangitsanso mitundu ya okosijeni yokhazikika (ROS) m'maselo a khansa, zomwe zimatsogolera ku apoptosis popanda kuvulaza ma cell abwinobwino, ndikupangitsa kuti ikhale yodalirika pa kafukufuku wa oncology.

Zofunika Kwambiri

• Kuyera: ≥98% (HPLC yotsimikizika)
• Nambala ya CAS: 20069-09-4
• Fomula Yamaselo: C₁₇H₁₉NO₅
• Kulemera kwa Maselo: 317.34 g/mol
• Maonekedwe: ufa woyera mpaka woyera
• Kusungunuka: Kusasungunuka m'madzi; sungunuka mu DMSO (≥10.45 mg/mL), ethanol, ndi zosungunulira zina organic
• Kusungirako: Sungani pa -20 ° C pamalo owuma, amdima. Wokhazikika kwa zaka 3 .

Njira Yochitira
Piperlongumine imayang'ana ma cell a khansa kudzera m'njira zingapo:

1. ROS Induction: Imakweza ma intracellular ROS, kuyambitsa kupsinjika kwa okosijeni ndi apoptosis m'maselo a khansa.
2. GSTP1 Kuletsa: Imalepheretsa glutathione S-transferase Pi 1 (GSTP1), kusokoneza redox bwino m'maselo oipa.
3. Kuponderezedwa kwa Njira ya STAT3: Imalepheretsa kusaina kwa STAT3, kuchepetsa kuchuluka kwa chotupa ndi kupulumuka.
4. Thioredoxin Reductase (TrxR1) Kuletsa: Imalunjika mosasinthika zotsalira za selenocysteine, kukulitsa chemosensitivity.

Ntchito Zofufuza

1. Chithandizo cha Khansa:
   • Imayambitsa apoptosis m'mawere, prostate, ndi myeloma cell mizere (IC₅₀: 1-5 μM).
   • Amagwirizanitsa ndi mankhwala a chemotherapy (mwachitsanzo, doxorubicin, cisplatin) kuti athetse kusamva mankhwala.
2. Maphunziro a Njira ya Signal:
   • Imasinthira NF-κB, MAPK, ndi JAK/STAT3 njira .
3. Neuroprotection & Kukalamba:
   • Imathandizira thanzi la neuronal ndikuchepetsa kupsinjika kwa oxidative mumitundu yokhudzana ndi zaka.
4. Kafukufuku wamtima:
   • Imalepheretsa atherosulinosis mwa kuletsa kuchulukana kwa minofu yosalala ya mitsempha.

Zofotokozera Zamalonda

Kusamalira & Chitetezo

• Kukonzanso: Sungunulani mu DMSO kwamu vitromaphunziro. Zamu vivopogwiritsira ntchito, gwiritsani ntchito polysorbate 80 kapena cyclodextrin-based formulations kuti muwonjezere kusungunuka.
• Kukhazikika: Kukhazikika pa pH 4-7. Pewani kuyatsa kwanthawi yayitali chifukwa chakuwonongeka kwa zithunzi.
• Chitetezo Chidziwitso: Zogwiritsa ntchito kafukufuku kokha. Sizinapangidwe kuti zigwiritsidwe ntchito pochiza matenda kapena kuchiza .

Chifukwa Chiyani Sankhani Piperlongumine Yathu?

• Chitsimikizo Choyera Kwambiri: Zolimba za QC kudzera pa HPLC ndi zolemba za MSDS/COA.
• Kupezeka Kwambiri: Kuphatikizika mwamakonda pazofuna zazikulu zofufuza.
• Kugwirizana Padziko Lonse: Kumakwaniritsa miyezo yapadziko lonse lapansi yamankhwala amtundu wa reagent.

Maumboni

1. Zosankha zothana ndi khansa kudzera mu induction ya ROS.
2. Kuchita bwino kwamankhwala ophatikiza.
3. Kusungunuka ndi kukhazikika mbiri.

Keywords: Piperlongumine ufa, kafukufuku wa anticancer, ROS induction, STAT3 inhibitor, alkaloid yapamwamba kwambiri.