Inoa Huahana: Pyrroloquinoline Quinone Disodium Salt
Helu CAS: 122628-50-6/ 72909-34-3
Kaumaha Molekala: 374.17/ 330.21
Ke Kumu Molekala: C14H4N2Na2O8/ C14H6N2O8
Hōʻike: PQQ Disodium Salt 99%; PQQ Acid 99%
Ke ʻano: ʻAlani ʻulaʻula a hiki i ka ʻulaʻula ʻulaʻula ʻulaʻula.
Noi: Hoʻohana nui ʻia no ka meaʻai meaʻai a me nā nutraceuticals.
Ka mālama ʻana: mālama ʻia ma kahi ʻoluʻolu a maloʻo, e haʻalele i ka lā pololei.
Nā kumu meaʻai Pyrroloquinoline Quinone
Loaʻa maoli ka PQQ i ka hapa nui o nā meaʻai meaʻai, nā huaʻai, a me nā mea kanu (trace), a hiki ke ʻike ʻia nā pae kiʻekiʻe o ka PQQ i nā huahana soy fermented, e like me ka kiwifruit, lychee, green beans, tofu, rapeseed, mustard, green tea (camellia), green pepper, spinach, etc.
ʻO G.Ua ʻike ʻo Haug ʻo ia ke kolu o ka redox cofactor i loko o ka bacteria ma hope o ka nicotinamide a me ka flavin (ʻoiai ua manaʻo ʻo ia he naphthoquinone). Ua loaʻa pū ʻo Anthony lāua ʻo Zatman i nā cofactors redox ʻike ʻole i ka ethanol dehydrogenase. I ka makahiki 1979, ua unuhi ʻo Salisbury a me kāna mau hoa a me Duine a me kā lākou mau hoa hana i kēia kumu pseudo mai ka methanol dehydrogenase o nā dinoflagellate a ʻike i kona ʻano mole. Ua ʻike ʻo Adachi a me kāna mau hoa i ka Acetobacter pū kekahi PQQ.
ʻO ka hana o ka Pyrroloquinoline Quinone
ʻO Pyrroloquinoline quinone (PQQ) kahi mole quinone liʻiliʻi, he hopena redox, hiki ke hoʻemi i ka oxidant (antioxidant); a laila hoʻihoʻi ʻia i loko o ke ʻano hana e ka glutathione. Me he mea lā ua kūpaʻa ʻo ia no ka mea hiki iā ia ke hana i nā kaukani o nā pōʻai ma mua o ka pau ʻana, a he mea hou ia no ka mea pili i ke ʻano o ka protein o nā cell (kekahi mau antioxidants, carotenoids nui e like me beta-carotene a me astaxanthin, aia ma nā wahi kikoʻī o nā cell, kahi e pāʻani ai lākou i nā kuleana antioxidant proportionally). Ma muli o ka pili, ʻike ʻia ka PQQ i kahi kuleana kokoke i nā protein e like me nā carotenoids ma nā membrane cell.
Hiki i kēia mau hana redox ke hoʻololi i nā hana protein a me nā ala transduction hōʻailona. ʻOiai he nui nā haʻawina hoʻohiki i loko o ka vitro (ma waho o nā hiʻohiʻona ola), kekahi mau hopena hoʻohiki o ka hoʻohui PQQ e pili nui ana i ka hoʻololi ʻana i kekahi mau ala transduction hōʻailona a i ʻole nā pono i ka mitochondria. (Hana hou a hoʻomaikaʻi i ka pono).
He coenzyme ia i loko o ka bacteria (no laila, no ka bacteria, ua like ia me B-vitamins), akā, ʻaʻole ia e hoʻonui i ke kanaka. No ka mea ʻaʻole pili kēia i nā kānaka, ʻōlelo ʻia kahi ʻatikala 2003 ma Nature, kahi puke pai ʻepekema ʻo ka manaʻo ʻo ka PQ he pūhui huaʻai ua kahiko ʻia a ʻoi aku ka maikaʻi o ka manaʻo he "mea like me ka vitamina."
ʻO ka mea kaulana loa ka hopena o ka PQQ ma ka mitochondria, e hāʻawi ana i ka ikehu (ATP) a hoʻoponopono i ka metabolism cell. Uaʻike nui nā mea noiʻi i ka hopena o ka PPQ ma ka mitochondria a uaʻikeʻo PQQ hiki ke hoʻonui i ka helu o ka mitochondria a me ka hoʻonui i ka pono o ka mitochondria. He kumu nui kēia e pono ai ka PPQ. ʻO nā enzyme e loaʻa ana i ka PQQ ka mea i ʻike ʻia he glucose dehydrogenase, he protein quinoa i hoʻohana ʻia ma ke ʻano he ʻike glucose.
Nā pōmaikaʻi o Pyrroloquinoline Quinone
ʻO ka loaʻa ʻana o ka mitochondria i ko lākou maikaʻi loa he mea nui ia no ke ola olakino e hiki ai iā ʻoe ke ʻike i nā pono he nui i ka wā e lawe ana i ka ppq. Eia kekahi o nā mea kaulana loa e pili ana i nā pono pyrroloquinoline quinone.
Hoʻonui i ka ikehu Pūnaewele
Ma muli o ka hoʻoulu ʻana o ka mitochondria i ka ikehu no nā cell, a kōkua ka PQQ i ka hana ʻoi aku ka maikaʻi o ka mitochondria, piʻi ka ikehu i loko o nā cell ma ke ʻano holoʻokoʻa; ʻO kēia ka Pyrroloquinoline Quinone mitochondrial mechanism. Hoʻohuli ʻia ka ikehu kelepona i hoʻohana ʻole ʻia i nā wahi ʻē aʻe o ke kino. Inā nele kou kino i ka mana i ka lā a pau, a i ʻole ʻoe e luhi a hiamoe paha, a laila he mea nui ka hoʻonui ʻana i ka ikaika o PPQ iā ʻoe. Ua ʻike kekahi haʻawina ma hope o ka lawe ʻana i ka PQQ, ʻoi aku ka haʻahaʻa o ka luhi o nā kumuhana me nā pilikia ikehu. Inā ʻoe e ʻimi nei i mea e hoʻonui ai i kou ikehu, hiki i ka PQQ ke kōkua me ia.
Kāohi i ka emi ʻana o ka naʻau
Me ka hoʻomohala ʻana o ka ʻepekema, ua ʻike nā kānaka ʻepekema hiki ke ulu a hoʻōla ke kumu ulu nerve (NGF). I ka manawa like, ua hōʻike ʻia ka PQQ i ka hopena maikaʻi i ka NGF a hoʻonui i ka ulu ʻana o ke aʻalolo e 40 mau manawa. Pono ʻo NGF no ka hoʻokumu ʻana a me ka mālama ʻana i nā neurons hou, a hiki iā ia ke hoʻihoʻi i nā neurons i hōʻino ʻia i hiki ke kāohi i ka hana cognitive. ʻO nā neurons nā pūnaewele e hoʻouna i ka ʻike, no laila hiki i ko mākou lolo ke kamaʻilio ma waena o lākou iho a me nā ʻāpana ʻē aʻe o ke kino. ʻO ka hoʻomaikaʻi ʻana i ka maikaʻi a me ka nui o nā neurons hiki ke hoʻomaikaʻi i ka cognition. No laila, loaʻa iā PQQ ka hoʻomaikaʻi pōkole.
Kākoʻo i ke olakino cardiovascular
Hāʻawi ka Pyrroloquinoline quinine i ke kākoʻo antioxidant a me ka mitochondrial. Ua hōʻike nā haʻawina e kākoʻo ana ʻo PQQ a me CoQ10 i ka hana myocardial a me ka hoʻohana pono ʻana i ka oxygen cellular. Kāohi ʻo Pyrroloquinoline quinone i ke koʻikoʻi oxidative ma o kāna hana hou ʻana.
Pyrroloquinoline Quinone Disodium Salt (PQQ): Nā Pōmaikaʻi, hoʻohana, a me ke alakaʻi palekana.
Hoʻolauna
ʻO Pyrroloquinoline Quinone Disodium Salt (PQQ) he ʻano paʻa, hiki ke hoʻoheheʻe ʻia i ka wai o PQQ, he cofactor redox me nā waiwai antioxidant ikaika. Loaʻa maoli ʻia i ka nui o nā meaʻai e like me ka kiwifruit, ka pā paʻi, a me nā pepa ʻōmaʻomaʻo, hoʻohana nui ʻia ʻo PQQ i nā meaʻai meaʻai no kāna mau pono cellular a neurological. Ma luna o 80% o nā mea hoʻohui pāʻoihana e hoʻohana i ka paʻakai disodium ma muli o kona hoʻonui ʻia a me ka bioavailability.
Nā mea nui
- Ke Kinohi Kinohi: C₁₄H₄N₂Na₂O₈ (Kapaona Molekala: 374.17)
- Ke ʻano: ʻulaʻula-ʻulaʻula a i ʻulaʻula-ʻalani pauka maikaʻi
- Maʻemaʻe: ≥98% (HPLC hōʻoia)
- Solubility: 3 g/L i ka wai ma 25°C
- Ola Paʻa: Paʻa no 36 mau mahina ke mālama ʻia i loko o nā pahu i hoʻopaʻa ʻia, mamao mai ka mālamalama a me ka maʻa.
Pono Ola
- Hoʻonui i ka Energy Cellular: Hoʻoulu ka PQQ i ka biogenesis mitochondrial, hoʻonui i ka hana ATP a me ka ikaika cellular.
- Kākoʻo i ka Cognitive Function: Hōʻike nā haʻawina lapaʻau i ka hoʻomaikaʻi ʻana i ka hoʻomanaʻo, ka maʻalahi o ka naʻau, a me ka wikiwiki hoʻokō, ʻoi aku ka nui o nā poʻe ʻōpio (20-40 mau makahiki).
- Nā hopena Antioxidant & Neuroprotective: Hoʻopau i nā radical manuahi, hoʻemi i ke kaumaha oxidative, a hoʻoikaika i ka synthesis nerve growth factor (NGF).
- ʻO ke ola kino: pale i ka pōʻino oxidative i loko o nā kīʻaha koko a kākoʻo i ka hana naʻau.
- Manaʻo Anti-Aging: Hoʻonui i ke olakino o ka ʻili ma ka hōʻemi ʻana i ka pōʻino oxidative a me ka hoʻomaikaʻi ʻana i ka synthesis collagen.
Nā noi a me ka hoʻohana ʻana
- Nā ʻano maʻamau: Manaʻo ʻia i kēlā me kēia lā: 10-20 mg no ke olakino maʻamau; Hiki ke hoʻohana ʻia nā mea kiʻekiʻe (a hiki i ka 40 mg) ma lalo o ka mākaʻi olakino.
- Capsules/Softgels: 10–20 mg (hui pinepine me CoQ10 no nā hopena synergistic) .
- ʻO ka pauka/wai: 7-20 mg no ka lawelawe ʻana, kūpono no ka hui ʻana o nā mea inu a i ʻole nā meaʻai hana.
- Hiki ke hoʻololi ʻia:
- PQQ Disodium Salt: Hiki ke hoʻoheheʻe ʻia i ka wai, kūpono no nā capsules, papa, a me nā mea inu pauka.
- PQQ Acid: Hiki ke hoʻoheheʻe ʻia i ka ʻaila, kūpono no nā ʻala palupalu a me nā mea inu emulsified.
Ka maikaʻi a me ka palekana
- ʻO ka hoʻāʻo ʻana o ka ʻaoʻao ʻekolu: hōʻoia ʻia no ka maʻemaʻe (≥98%) a me ka haʻahaʻa haʻahaʻa haʻahaʻa haʻahaʻa (lead ≤0.5 ppm, arsenic ≤1 ppm) .
- Palekana Palekana: ʻIke ʻia ma ke ʻano he palekana (GRAS) i nā kau i ʻōlelo ʻia. E kūkākūkā i kahi mea mālama ola inā hāpai, hānai, a lawe lāʻau paha.
- Waihona: E kūʻai ma kahi maloʻo maloʻo (2–8°C) e mālama i ka paʻa.
Nā Manaʻo Nui
- Nā Puna Kūlohelohe vs. Nā mea hoʻohui: ʻOiai aia ka PQQ i nā meaʻai, pono ka hoʻohui ʻana no ka loaʻa ʻana o nā kumu lāʻau lapaʻau.
- Kūlana Hoʻoponopono: Ua ʻae ʻia ma ke ʻano he meaʻai meaʻai hou ma EU a me Kina, me ka noiʻi mau e hoʻonui i nā noi.
