Ityuwa yePyrroloquinoline Quinone disodium (PQQ)

I-Pyrroloquinoline quinone (PQQ), eyaziwa ngokuba yi-Methoxy Platinum, yi-cofactor ye-redox.Ikhona emhlabeni, i-kiwifruit, ukutya, kunye nobisi lwebele lomntu.Ukuthetha ngokuthe ngqo, igama elithi "pyrroloquinoline quinone" lincinci kancinci, ke uninzi lwabantu lukhetha ukusebenzisa isishunqulelo sePQQ.Ijenali yenzululwazi iNature yapapasha iphepha nguKasahara noKato ngo-2003, elithathela ingqalelo i-PQQ yivithamin entsha.Nangona kunjalo, emva kokuqhubeka malunga nophando lwe-pyrroloquinoline quinone, abaphandi bafumanisa ukuba nangona ineepropathi ezinjenge-vitamin, sisondlo esinxulumeneyo kuphela.I-PQQ inokusetyenziswa njenge-co-factor okanye umgqugquzeli we-enzymatic kwinkqubo ye-redox.I-PQQ inesiphumo esithile se-antioxidant ngenxa yokuthatha inxaxheba kwi-redox.

Igama lemveliso:Ityuwa yePyrroloquinoline Quinone Disodium

Inombolo yeCAS: 122628-50-6/ 72909-34-3

Ubunzima beMolekyuli: 374.17/ 330.21

Ifomula yemolekyuli: C14H4N2Na2O8/ C14H6N2O8

Inkcazo:PQQ Disodium yeTyuwa 99%;PQQ Acid 99%

Imbonakalo: Ebomvu e-orenji ukuya kwiPowder eNgcono eBomvu.

Isicelo: Isetyenziswa ngokubanzi kwisondlo sokutya kunye ne-nutraceuticals.

Ukugcinwa: Igcinwe kwindawo ekhululekile kunye neyomileyo, suka kwilanga elithe ngqo.

Pyrroloquinoline Quinoneimithombo yokutya

I-PQQ ngokwemvelo ikhona kuninzi lokutya kwemifuno, iziqhamo, kunye nemifuno (umkhondo), kwaye amanqanaba aphezulu e-PQQ anokubonwa kwiimveliso zesoya ezibilisiweyo, ezifana ne-kiwifruit, i-lychee, iimbotyi eziluhlaza, i-tofu, i-rapeseed, i-mustard, iti eluhlaza (camellia) , ipepile eluhlaza, isipinatshi, njl.

G.UHaug wafumanisa ukuba yayiyeyesithathu i-redox cofactor kwiibhaktheriya emva kwe-nicotinamide kunye ne-flavin (nangona wayecinga ukuba yi-naphthoquinone).U-Anthony noZatman bafumene iicofactors ze-redox ezingaziwayo kwi-ethanol dehydrogenase.Ngo-1979, u-Salisbury kunye noogxa bakhe kunye no-Duine kunye noogxa babo bakhupha esi siseko se-pseudo kwi-methanol dehydrogenase ye-dinoflagellate kwaye bachonga isakhiwo sayo se-molecular.U-Adachi kunye noogxa bakhe bafumanisa ukuba i-Acetobacter nayo iqulethe i-PQQ.

Indlela yokusebenza yePyrroloquinoline Quinone

I-Pyrroloquinoline quinone (PQQ) yi-molecule encinci ye-quinone, enefuthe le-redox, inokunciphisa i-oxidant (i-antioxidant);emva koko ibuyiselwe kwifom esebenzayo nge-glutathione.Kubonakala ngathi izinzile ngenxa yokuba inokuhamba amawaka emijikelo ngaphambi kokuncipha, kwaye intsha kuba inxulumene nolwakhiwo lweprotheyini yeeseli (ezinye i-antioxidants, i-carotenoids ephambili efana ne-beta-carotene kunye ne-astaxanthin, zikwindawo ezithile zeeseli, apho badlala iindima ezininzi ze-antioxidant ngokulinganayo).Ngenxa yokusondela, i-PQQ ibonakala idlala indima kufutshane neeproteni ezinje nge-carotenoids kwiinwebu zeseli.

Le misebenzi ye-redox inokuguqula imisebenzi yeprotheyini kunye neendlela zokudlulisa umqondiso.Nangona zininzi izifundo ezithembisayo kwi-vitro (iimodeli zokuhlala zangaphandle), ezinye iziphumo ezithembisayo zongezelelo lwe-PQQ zinxulumene ikakhulu nokutshintsha ezinye iindlela zokuhambisa umqondiso okanye izibonelelo zabo kwi-mitochondria.(Ukuvelisa ngakumbi kunye nokuphucula ukusebenza kakuhle).

I-coenzyme kwiibhaktheriya (ngoko ibhaktheriya, ifana ne-B-vitamins), kodwa ayibonakali ukuba yandisa ebantwini.Ekubeni oku kungasebenzi ebantwini, inqaku lika-2003 kwiNature, ulindixesha wenzululwazi, liphikisa ukuba ingcamango yokuba i-PQ yikhompawundi yevithamini iphelelwe lixesha kwaye eyona nto ithathwa njenge "into efana ne-vitamin."

Mhlawumbi eyona nto iphawulekayo yimpembelelo ye-PQQ kwi-mitochondria, enika amandla (ATP) kunye nokulawula i-cell metabolism.Abaphandi baye baqaphela ngokubanzi impembelelo ye-PPQ kwi-mitochondria kwaye bafumanisa ukuba i-PQQ inokunyusa inani le-mitochondria kunye nokuphucula ukusebenza kakuhle kwe-mitochondria.Esi sisizathu esibalulekileyo sokuba kutheni iPPQ iluncedo.Iienzymes eziqulethe i-PQQ zaziwa njengeglucose dehydrogenase, iprotein yequinoa esetyenziswa njengesivamvo seswekile.

Izibonelelo zePyrroloquinoline Quinone

Ukuba ne-mitochondria kokona kulungileyo kubaluleke kakhulu kubomi obunempilo kangangokuba unokufumana izibonelelo ezininzi ngelixa uthatha i-ppq.Nazi ezinye zezona zinto zibalulekileyo malunga neenzuzo ze-pyrroloquinoline quinone.

Ukwandisa amandla eSeli

Ngenxa yokuba i-mitochondria ivelisa amandla kwiiseli, kwaye i-PQQ inceda i-mitochondria isebenze ngokufanelekileyo, amandla kwiiseli ayanda xa ewonke;le yindlela yePyrroloquinoline Quinone mitochondrial.Amandla eselula angasetyenziswanga athunyelwa kwamanye amalungu omzimba.Ukuba umzimba wakho awunamandla imini yonke, okanye uziva udiniwe okanye usozela, ke ukonyuka kwamandla e-PPQ kubalulekile kuwe.Olunye uphononongo lwafumanisa ukuba emva kokuthatha i-PQQ, izifundo ezineengxaki zamandla ezixeliweyo zinemigangatho esezantsi kakhulu yokudinwa.Ukuba ujonge into yokwandisa amandla akho, i-PQQ inokunceda kuloo nto.

Ukuthintela ukuhla kwengqondo

Ngophuhliso lwesayensi, izazinzulu ziye zafumanisa ukuba i-nerve growth factor (NGF) inokukhula kwaye ihlaziyeke.Ngelo xesha, i-PQQ ibonakaliswe ukuba inefuthe elihle kwi-NGF kunye nokwandisa ukukhula kwe-nerve ngamaxesha e-40.I-NGF ibalulekile ekubunjweni nasekugcinweni kwee-neurons ezintsha, kwaye inokubuyisela i-neurons eyonakalisiweyo enokuthintela umsebenzi wokuqonda.I-Neurons ziiseli ezihambisa ulwazi, ngoko ubuchopho bethu bunokunxibelelana phakathi kwabo kunye namanye amalungu omzimba.Ukuphucula umgangatho kunye nobuninzi bee-neurons kunokuphucula ukuqonda.Ke ngoko, i-PQQ inokuphuculwa kwexesha elifutshane.

Ukuxhasa impilo ye-cardiovascular

I-Pyrroloquinoline quinine ibonelela ngenkxaso ye-antioxidant kunye ne-mitochondrial.Izifundo zibonise ukuba zombini i-PQQ kunye ne-CoQ10 zixhasa umsebenzi we-myocardial kunye nokusetyenziswa okufanelekileyo kwe-oksijini yeselula.I-Pyrroloquinoline quinone ikhusela uxinzelelo lwe-oxidative ngokuvuselelwa kwayo.

Okunye Ukusebenza:

Ngaphandle kwezibonelelo ezintathu eziphambili ezidweliswe ngasentla, i-PQQ ibonelela ngezinye izibonelelo ezingaziwayo.I-PQQ inokudlala indima ekudambiseni ukudumba komzimba, ukulala ngcono kwaye kunokuphucula ukuchuma, kodwa uphando oluninzi luyafuneka ukwenza izigqibo eziqinisekileyo.Njengoko uphando luqhubela phambili, izibonelelo ezininzi zokuthatha i-PQQ zinokufunyanwa.

Umthamo wePyrroloquinoline Quinone

Okwangoku, akukho rhulumente okanye i-WHO ichaze idosi ye-pyrroloquinoline quinone.Nangona kunjalo, abanye abantu kunye namaziko enze iimvavanyo ezininzi zebhayoloji kunye neemvavanyo zabantu kwidosi efanelekileyo ye-pyrroloquinoline quinone powder.Ngokujonga kunye nokuthelekisa ukusebenza ngokomzimba kwezifundo, kugqitywa ukuba idosi efanelekileyo ye-PQQ yi-20 mg-50 mg.Hlala uthumela ugqirha wakho ukuba kukho nayiphi na imibuzo esalindileyo.Enje ngebiopqq pyrroloquinoline quinone disodium ityuwa.

Iziphumo ebezingalindelekanga zePQQ

Ukususela kwi-2009, izongezo zokutya eziqulethe i-PQQ Na 2 ziye zathengiswa e-United States emva kokwaziswa ngokusemthethweni yi-Food and Drug Administration (FDA), kwaye akukho zithintelo ezimbi eziye zabikwa.Ukuba ufuna ukongeza izongezo ze-pyrroloquinoline quinone kukutya kwakho, kubalulekile ukukhumbula into enye.Kuba ayifuni i-PQQ eninzi kakhulu ukuvelisa isiphumo, uninzi lweedosi zigcinwa kuluhlu oluncinci.Ke ngoko, uninzi lwabantu alunaxhala malunga neziphumo ebezingalindelekanga zePyrroloquinoline Quinone.(Nguwo lo uthenge isongezelelo se-pyrroloquinoline quinone PQQimakethi)