I-Pyrroloquinoline Quinone disodium Salt(PQQ)

I-Pyrroloquinoline Quinone disodium Salt(PQQ) Isithombe Esifakiwe
  • I-Pyrroloquinoline Quinone disodium Salt(PQQ)

Incazelo emfushane:

I-Pyrroloquinoline quinone (PQQ), eyaziwa nangokuthi i-Methoxy Platinum, iyi-cofactor ye-redox. Itholakala enhlabathini, i-kiwifruit, ukudla, nobisi lwebele lomuntu. Uma sikhuluma ngokuqondile, igama elithi “pyrroloquinoline quinone” alikho kahle, ngakho-ke abantu abaningi bakhetha ukusebenzisa isifinyezo esithi PQQ. Ijenali yesayensi i-Nature yashicilela iphepha likaKasahara noKato ngo-2003, elalibheka i-PQQ ivithamini entsha. Kodwa-ke, ngemuva kokuqhubeka ngocwaningo lwe-pyrroloquinoline quinone, abacwaningi banqume ukuthi nakuba inezinto ezifana ne-vitamin, iwumzimba ohlobene kuphela. I-PQQ ingasetshenziswa njenge-co-factor noma umgqugquzeli we-enzymatic kunqubo ye-redox. I-PQQ inomphumela othize we-antioxidant ngenxa yokubamba iqhaza kwayo ku-redox.

I-PQQ yi-pyrroloquinoline quinone. Kwesinye isikhathi ibizwa nge-methoxatin, i-pyrroloquinoline quinone disodium usawoti, kanye nevithamini yokuphila isikhathi eside. Kuyinhlanganisela eyenziwe amagciwane futhi itholakala ezithelweni nemifino. I-PQQ ekubhaktheriya ibasiza ekugayeni utshwala noshukela, okwenza amandla.


  • Intengo ye-FOB:US 5 - 2000 / KG
  • Inani elincane le-oda:1 KG
  • Ikhono Lokuhlinzeka:10000 KG/ngenyanga
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  • Imigomo Yokuthumela:Ngasolwandle/Ngomoya/Nge-Courier
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    Imininingwane Yomkhiqizo

    Omaka bomkhiqizo

    Igama lomkhiqizo:Pyrroloquinoline Quinone disodium Salt

    Inombolo ye-CAS: 122628-50-6/ 72909-34-3

    Isisindo samangqamuzana: 374.17/ 330.21

    I-Molecular Formula: C14H4N2Na2O8/ C14H6N2O8

    Ukucaciswa:PQQ Disodium Salt 99%;PQQ Acid 99%

    Ukubukeka: Owolintshi obomvu ukuya ku-Reddish Brown Fine Powder.

    Isicelo: Isetshenziselwa kakhulu isithasiselo sokudla kanye ne-nutraceuticals.

    Isitoreji: Igcinwe endaweni ekhululekile futhi eyomile, balekela ilanga eliqondile.

    Imithombo yokudla ye-Pyrroloquinoline Quinone

    I-PQQ ngokwemvelo ikhona ekudleni kwemifino eminingi, izithelo, kanye nemifino (umkhondo), futhi amazinga aphezulu e-PQQ angatholwa emikhiqizweni kabhontshisi wesoya, njenge-kiwifruit, i-lychee, ubhontshisi oluhlaza, i-tofu, imbewu ye-rapese, isinaphi, itiye eliluhlaza (camellia), upelepele oluhlaza, isipinashi, njll.

    G.U-Haug uthole ukuthi kwakuyi-cofactor yesithathu ye-redox kubhaktheriya ngemva kwe-nicotinamide ne-flavin (nakuba ayecabanga ukuthi kwakuyi-naphthoquinone). U-Anthony no-Zatman baphinde bathola ama-cofactors e-redox angaziwa ku-ethanol dehydrogenase. Ngo-1979, u-Salisbury nozakwabo kanye no-Duine nozakwabo bakhipha lesi sisekelo mbumbulu ku-methanol dehydrogenase ye-dinoflagellate futhi bahlonza isakhiwo sayo samangqamuzana. U-Adachi nozakwabo bathola ukuthi i-Acetobacter nayo iqukethe i-PQQ.

    Indlela yokusebenza ye-Pyrroloquinoline Quinone

    I-Pyrroloquinoline quinone (PQQ) iyingqamuzana elincane le-quinone, elinomphumela we-redox, linganciphisa i-oxidant (antioxidant); bese ibuyiselwa esimweni esisebenzayo nge-glutathione. Ibukeka izinzile ngoba ingadlula izinkulungwane zemijikelezo ngaphambi kokuncipha, futhi yintsha ngoba ihlobene nesakhiwo samaprotheni samaseli (amanye ama-antioxidants, ama-carotenoid ayinhloko afana ne-beta-carotene ne-astaxanthin, atholakala ezindaweni ezithile zamaseli, lapho adlala khona izindima eziningi ze-antioxidant ngokulinganayo). Ngenxa yokusondelana, i-PQQ ibonakala idlala indima eduze kwamaprotheni anjenge-carotenoid kulwelwesi lwamaseli.

    Le misebenzi ye-redox ingashintsha imisebenzi yamaprotheni kanye nezindlela zokudlulisela isignali. Yize kunezifundo eziningi ezithembisayo ku-vitro (amamodeli aphilayo angaphandle), eminye imiphumela ethembisayo yokwengeza i-PQQ ihlobene kakhulu nokuguqula ezinye izindlela zokudlulisa amasignali noma izinzuzo zazo zibe yi-mitochondria. (Khiqiza okwengeziwe futhi uthuthukise ukusebenza kahle).

    Kuyi-coenzyme kubhaktheriya (ngakho kubhaktheriya, kufana namavithamini B), kodwa akubonakali kudlulele kubantu. Njengoba lokhu kungasebenzi kubantu, isihloko sango-2003 ku-Nature, iphephabhuku lesayensi, sithi umbono wokuthi i-PQ iyinhlanganisela yamavithamini usuphelelwe yisikhathi futhi ubhekwa “njengento efana ne-vitamin.”

    Mhlawumbe okuphawuleka kakhulu umphumela we-PQQ ku-mitochondria, enikeza amandla (ATP) futhi ilawule umzimba weseli. Abacwaningi bawubone kakhulu umthelela we-PPQ ku-mitochondria futhi bathola ukuthi i-PQQ ingakhuphula inani le-mitochondria futhi ithuthukise nokusebenza kahle kwe-mitochondria. Lesi yisizathu esibalulekile esenza i-PPQ isebenziseke kangaka. Ama-enzyme aqukethe i-PQQ aziwa njenge-glucose dehydrogenase, iphrotheni ye-quinoa esetshenziswa njengenzwa ye-glucose.

    Izinzuzo ze-Pyrroloquinoline Quinone

    Ukuba ne-mitochondria ngesikhathi esihle kakhulu kubaluleke kakhulu empilweni enempilo kangangokuthi ungathola izinzuzo eziningi ngenkathi uthatha i-ppq. Nazi ezinye zezinzuzo eziphawuleka kakhulu nge-pyrroloquinoline quinone.

    Ukwandisa Amandla Eseli

    Ngenxa yokuthi i-mitochondria ikhiqiza amandla amangqamuzana, futhi i-PQQ isiza i-mitochondria ukuthi isebenze ngokuphumelelayo, amandla kumaseli akhula ewonke; lena indlela ye-Pyrroloquinoline Quinone mitochondrial. Amandla eselula angasetshenzisiwe adluliselwa kwezinye izingxenye zomzimba. Uma umzimba wakho ungenamandla usuku lonke, noma uzizwa ukhathele noma wozela, khona-ke amandla akhulayo e-PPQ abalulekile kuwe. Olunye ucwaningo lwathola ukuthi ngemva kokuthatha i-PQQ, izifundo ezinezinkinga zamandla ezibikiwe zazinamazinga aphansi kakhulu okukhathala. Uma ufuna okuthile okungakhulisa amandla akho, i-PQQ ingasiza ngalokho.

    Ukuvimbela ukwehla kwengqondo

    Ngokuthuthuka kwesayensi, ososayensi bathole ukuthi i-nerve growth factor (NGF) ingakhula futhi ilulame. Ngesikhathi esifanayo, i-PQQ iboniswe ukuthi inomthelela omuhle ku-NGF futhi yandisa ukukhula kwezinzwa ngezikhathi ze-40. I-NGF ibalulekile ekwakhekeni nasekugcinweni kwama-neuron amasha, futhi ingabuyisela ama-neurons awonakele angase avimbele ukusebenza kwengqondo. Ama-Neurons amangqamuzana adlulisa ulwazi, ngakho ubuchopho bethu bungakwazi ukuxhumana phakathi kwabo nezinye izingxenye zomzimba. Ukuthuthukisa ikhwalithi nenani lama-neurons kungathuthukisa ukuqonda. Ngakho-ke, i-PQQ inokuthuthukiswa kwesikhashana.

    Ukusekela impilo yenhliziyo nemithambo yegazi

    I-Pyrroloquinoline quinine inikeza ukwesekwa kwe-antioxidant ne-mitochondrial. Ucwaningo luye lwabonisa ukuthi kokubili i-PQQ ne-CoQ10 isekela ukusebenza kwe-myocardial kanye nokusetshenziswa okufanele komoyampilo weselula. I-Pyrroloquinoline quinone ivimbela ingcindezi ye-oxidative ngokuvuselelwa kwayo.

    I-Pyrroloquinoline Quinone Disodium Salt (PQQ): Izinzuzo, Ukusetshenziswa, kanye Nomhlahlandlela Wokuphepha

    Isingeniso
    I-Pyrroloquinoline Quinone Disodium Salt (PQQ) iwuhlobo oluzinzile, oluncibilika emanzini lwe-PQQ, i-redox cofactor enezici ezinamandla zokulwa ne-antioxidant. Itholakala ngokwemvelo ngamanani amancane ekudleni okufana ne-kiwifruit, i-parsley, nopelepele oluhlaza, i-PQQ isetshenziswa kabanzi ezithasiselweni zokudla ngezinzuzo zayo zamaselula nezinzwa. Ngaphezu kuka-80% wezithako ezithengiswayo zisebenzisa usawoti we-disodium ngenxa yokuqina kwawo okuthuthukisiwe kanye nokuba khona kwe-bioavailability.

    Izici Eziyinhloko

    • I-Chemical Formula: C₁₄H₄N₂Na₂O₈ (Isisindo se-Molecular: 374.17)
    • Ukubukeka: Okubomvu-kunsundu ukuya kokubomvu-owolintshi okuyimpushana
    • Ubumsulwa: ≥98% (HPLC iqinisekisiwe)
    • Ukunyibilika: 3 g/L emanzini ku-25°C
    • Impilo Yeshelufu: Izinzile izinyanga ezingama-36 lapho igcinwe ezitsheni ezivaliwe, kude nokukhanya kanye nomswakama.

    Izinzuzo Zezempilo

    1. Ithuthukisa Amandla Eselula: I-PQQ yenza kusebenze i-mitochondrial biogenesis, ithuthukisa ukukhiqizwa kwe-ATP namandla eselula.
    2. Isekela Umsebenzi Wokuqonda: Ucwaningo lwezokwelapha lubonisa inkumbulo ethuthukisiwe, ukuguquguquka kwengqondo, nesivinini sokuphatha, ikakhulukazi kubantu abadala abancane (iminyaka engu-20-40).
    3. I-Antioxidant & Neuroprotective Effects: Ingathathi hlangothi ama-radicals mahhala, inciphisa ukucindezeleka kwe-oxidative, futhi ikhuthaze ukuhlanganiswa kwe-nerve growth factor (NGF).
    4. Impilo Yenhliziyo: Ivikela ekulimaleni kwe-oxidative emithanjeni yegazi futhi isekele ukusebenza kwenhliziyo.
    5. I-Anti-Aging Amandla: Ithuthukisa impilo yesikhumba ngokunciphisa ukulimala kwe-oxidative futhi ithuthukise ukwakheka kwe-collagen.

    Izicelo Nesilinganiso

    • Amafomu Ajwayelekile:Ukudla Okunconyiwe Kwansuku zonke: 10–20 mg empilweni jikelele; imithamo ephezulu (kufika ku-40 mg) ingasetshenziswa ngaphansi kokuqondisa kodokotela.
      • Amaphilisi/Ama-Softgels: 10–20 mg (ngokuvamile ahlanganiswe ne-CoQ10 ngemiphumela ye-synergistic) .
      • Ama-Powders/Liquids: 7-20 mg ngokuphakwa ngakunye, ilungele izingxube zeziphuzo noma ukudla okusebenzayo .
    • Ukuguquguquka Kokwakheka:
      • I-PQQ Disodium Salt: Incibilika emanzini, ilungele amaphilisi, amaphilisi, neziphuzo eziyimpuphu.
      • I-PQQ Acid: Incibilika kuwoyela, ilungele ama-softgels neziphuzo ezifakwe emulsified.

    Ikhwalithi Nokuphepha

    • Ukuhlola Kwenkampani Yangaphandle: Kuqinisekiselwe ubumsulwa (≥98%) nokuqukethwe kwensimbi esindayo ephansi (umthofu ≤0.5 ppm, i-arsenic ≤1 ppm) .
    • Iphrofayili Yezokuphepha: Ngokuvamile ibonwa njengephephile (i-GRAS) kumithamo enconyiwe. Xhumana nomhlinzeki wezempilo uma ukhulelwe, uncelisa, noma uphuza imithi .
    • Isitoreji: Gcina endaweni epholile, eyomile (2–8°C) ukuze ugcine uzinzo.

    Ukucatshangelwa Okubalulekile

    • Imithombo Yemvelo vs. Izithasiselo: Nakuba i-PQQ ikhona ekudleni, ukugcwalisa kuyadingeka ukuze kuzuzwe imithamo esebenza ngempumelelo emtholampilo .
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