Zita reChigadzirwa:Pyrroloquinoline Quinone disodium Munyu
Nhamba yeCAS: 122628-50-6/ 72909-34-3
Molecular Weight: 374.17/ 330.21
Molecular Formula: C14H4N2Na2O8/ C14H6N2O8
Zvinodiwa: PQQ Disodium Munyu 99%; PQQ Acid 99%
Kuonekwa: Reddish orenji kusvika kuReddish Brown Fine Powder.
Kushanda: Inoshandiswa zvakanyanya pakudya kwekuwedzera uye nutraceuticals.
Kuchengetedza: Yakachengetwa munzvimbo yakasununguka uye yakaoma, ibva kune zuva rakananga.
Pyrroloquinoline Quinone chikafu masosi
PQQ inongowanikwa muzvikafu zvakawanda zvemiriwo, michero, uye miriwo (trace), uye huwandu hwakanyanya hwePQQ hunogona kuwanikwa muzvigadzirwa zvesoya zvakaviriswa, senge kiwifruit, lychee, bhinzi bhinzi, tofu, rapeseed, mustard, green tea (camellia), green pepper, sipinachi, nezvimwe.
G.Haug akawana kuti yaive yechitatu redox cofactor mubhakitiriya mushure menicotinamide uye flavin (kunyangwe aifungidzira kuti yaive naphthoquinone). Anthony naZatman vakawanawo zvisingazivikanwe redox cofactors mu ethanol dehydrogenase. Muna 1979, Salisbury nevamwe vake pamwe naDuine nevamwe vavo vakabvisa iyi pseudo base kubva kumethanol dehydrogenase ye dinoflagellates uye vakaziva chimiro chayo chemorekuru. Adachi nevamwe vake vakawana kuti Acetobacter inewo PQQ.
Mechanism yekuita kwePyrroloquinoline Quinone
Pyrroloquinoline quinone (PQQ) idiki quinone molecule, ine redox mhedzisiro, inogona kuderedza oxidant (antioxidant); inobva yadzoserwa muchimiro chekushanda ne glutathione. Inoratidzika kunge yakagadzikana nekuti inogona kutenderera zviuru zvema cycle isati yapera, uye inyowani nekuti ine hukama neprotein chimiro chemasero (mamwe ma antioxidants, main carotenoids akadai se beta-carotene uye astaxanthin, ari munzvimbo dzakatarwa dzemasero, kwavanotamba mamwe mabasa e antioxidant zvakaenzana). Nekuda kwepedyo, PQQ inoita kunge ichiita basa padyo nemapuroteni akadai secarotenoids pamasero membranes.
Aya mabasa eredox anogona kushandura mapuroteni mabasa uye masaini ekutapurirana nzira. Kunyangwe paine akawanda anovimbisa zvidzidzo mu vitro (kunze kwemamodheru ekurarama), mamwe anovimbisa mhedzisiro yePQQ yekuwedzera ane hukama nekuchinja mamwe masaini ekufambisa nzira kana mabhenefiti avo kune mitochondria. (Gadzira zvakawanda uye uvandudze hunyanzvi).
Iyo coenzyme mubhakitiriya (saka kune mabhakitiriya, yakafanana neB-vitamini), asi hairatidzike kuwedzera kuvanhu. Sezvo izvi zvisingashande kuvanhu, chinyorwa chemuna 2003 muNature, magazini yesainzi, chinopokana kuti pfungwa yekuti PQ musanganiswa wevhitamini ndeyechinyakare uye zvinonyanya kutorwa se "chinhu chakaita sevhitamini."
Zvichida chinonyanya kucherechedzwa mhedzisiro yePQQ pane mitochondria, iyo inopa simba (ATP) uye inogadzirisa sero metabolism. Vatsvagiri vakatarisa zvakanyanya kuita kwePPQ pamitochondria uye vakawana kuti PQQ inogona kuwedzera huwandu hwemitochondria uye kunyange kunatsiridza kushanda kwe mitochondria. Ichi chikonzero chakakosha nei PPQ ichibatsira. Ma Enzymes ane PQQ anozivikanwa seglucose dehydrogenase, quinoa protein inoshandiswa seglucose sensor.
Zvakanakira zvePyrroloquinoline Quinone
Kuve nemitochondria pazvakanakisa kwakakosha kune hupenyu hune hutano zvekuti unogona kuwana mabhenefiti akawanda uchitora ppq. Heano mamwe anonyanya kukosha nezve pyrroloquinoline quinone mabhenefiti.
Kuwedzera Sero Simba
Nekuti mitochondria inogadzira simba remasero, uye PQQ inobatsira mitochondria kushanda zvakanyanya, simba mumaseru rinowedzera rose; iyi ndiyo Pyrroloquinoline Quinone mitochondrial mechanism. Simba remaserura risingashandiswe rinoendeswa kune dzimwe nhengo dzemuviri. Kana muviri wako usina simba zuva rose, kana kuti unonzwa wakaneta kana kutsimwaira, ipapo kuwedzera kwesimba rePPQ kwakakosha kwauri. Imwe ongororo yakawana kuti mushure mekutora PQQ, zvidzidzo zvine dambudziko resimba rakashumwa zvaive nemazinga akaderera ekuneta. Kana iwe uchitsvaga chimwe chinhu chekuwedzera simba rako, PQQ inogona kubatsira nazvo.
Kudzivirira kuderera kwekuziva
Nekuvandudzwa kwesainzi, masayendisiti akawana kuti nerve growth factor (NGF) inogona kukura nekupora. Panguva imwecheteyo, PQQ yakaratidzwa kuva nemigumisiro yakanaka paNGF uye kuwedzera kukura kwetsinga ne40 nguva. NGF inokosha pakuumbwa nekuchengetedza neuroni itsva, uye inogona kudzorera neuroni dzakakanganisika dzinogona kudzivisa kushanda kwekuziva. Neurons ndiwo masero anotumira ruzivo, saka uropi hwedu hunogona kutaurirana pakati pavo nedzimwe nhengo dzemuviri. Kuvandudza hunhu uye huwandu hwema neuroni hunogona kuvandudza cognition. Naizvozvo, PQQ ine kuvandudzwa kwenguva pfupi.
Kutsigira hutano hwemwoyo
Pyrroloquinoline quinine inopa antioxidant uye mitochondrial rutsigiro. Zvidzidzo zvakaratidza kuti zvese PQQ uye CoQ10 inotsigira myocardial basa uye kwakaringana cellular okisijeni kushandiswa. Pyrroloquinoline quinone inodzivirira oxidative kusagadzikana kuburikidza nekuvandudzwa kwayo.
Pyrroloquinoline Quinone disodium Munyu (PQQ): Mabhenefiti, Mashandisirwo, uye Chengetedzo Gwaro
Nhanganyaya
Pyrroloquinoline Quinone disodium Munyu (PQQ) yakagadzikana, inonyungudika mvura fomu yePQQ, redox cofactor ine simba antioxidant zvimiro. Inowanikwa zvakasununguka muhuwandu hwekutsvaga muzvikafu zvakaita se kiwifruit, parsley, uye girinhi mhiripiri, PQQ inoshandiswa zvakanyanya mukudya kwekuwedzera kune yayo maseru uye neurological mabhenefiti. Anopfuura makumi masere muzana ezvekutengesa ekuwedzera anoshandisa iyo disodium munyu fomu nekuda kwekusimba kwayo kusimba uye bioavailability.
Key Features
- Mushonga weKemikari: C₁₄H₄N₂Na₂O₈ (Muremu weMorecular: 374.17)
- Kuonekwa: Tsvuku-tsvuku kune tsvuku-orenji poda yakanaka
- Kuchena: ≥98% (HPLC yakasimbiswa)
- Solubility: 3 g/L mumvura pa25°C
- Sherufu Hupenyu: Yakagadzikana kwemwedzi makumi matatu nematanhatu kana yakachengetwa mumidziyo yakavharwa, kure nechiedza uye mwando.
Utano Benefits
- Inowedzera Serura Simba: PQQ inomutsa mitochondrial biogenesis, inosimudzira ATP kugadzirwa uye cellular simba.
- Inotsigira Cognitive Basa: Zvidzidzo zvekiriniki zvinoratidza ndangariro dzakavandudzwa, kugona kuchinjika, uye kumhanya kwepamusoro, kunyanya muvakuru vechidiki (20-40 makore).
- Antioxidant & Neuroprotective Effects: Neutralizes mahara radicals, inoderedza oxidative kusagadzikana, uye inosimudzira nerve yekukura factor (NGF) synthesis.
- Cardiovascular Health: Inodzivirira kubva mukukuvadzwa kweoxidative mutsinga uye inotsigira basa remoyo.
- Anti-Kuchembera Inogona: Inovandudza hutano hweganda nekudzikisa kukuvara kweoxidative uye kugadzirisa collagen synthesis.
Applications & Dosage
- Mafomu Anowanikwa: Inokurudzirwa Kudya Kwezuva Nezuva: 10-20 mg yehutano huzhinji; madhasi epamusoro (anosvika 40 mg) anogona kushandiswa ari pasi pekutariswa nachiremba.
- Capsules/Softgels: 10-20 mg (kazhinji inosanganiswa neCoQ10 ye synergistic effects) .
- Powders/Liquids: 7-20 mg pasevhisi, yakanakira kusanganiswa kwezvinwiwa kana chikafu chinoshanda.
- Formulation Flexibility:
- PQQ Disodium Munyu: Mvura-inonyungudika, yakakodzera macapsules, mahwendefa, uye zvinwiwa zvehupfu.
- PQQ Acid: Oiri-inonyungudika, yakanakira softgels uye emulsified zvinwiwa.
Hunhu & Kuchengetedzeka
- Chechitatu-Bato Kuedzwa: Yakavimbiswa kuchena (≥98%) uye yakaderera heavy metal content (lead ≤0.5 ppm, arsenic ≤1 ppm) .
- Chengetedzo Profile: Inowanzo zivikanwa seyakachengeteka (GRAS) pamadhora anokurudzirwa. Bvunza varapi vehutano kana vaine pamuviri, vachiyamwisa, kana kunwa mishonga .
- Kuchengeta: Chengeta munzvimbo inotonhorera, yakaoma (2–8°C) kuchengetedza kugadzikana.
Pfungwa Huru
- Natural Source vs. Zvekuwedzera: Nepo PQQ iripo muzvikafu, yekuwedzera inodiwa kuti uwane kliniki inoshanda madosi.
- Regulatory Status: Yakatenderwa sechinhu chitsva chekudya muEU neChina, netsvakiridzo inoenderera mberi yekuwedzera maapplication.
