Pyrroloquinoline Quinone Disodium Salt (PQQ)

Dzina lazogulitsa: Pyrroloquinoline Quinone Disodium Salt

Nambala ya CAS: 122628-50-6/ 72909-34-3

Kulemera kwa Maselo: 374.17/ 330.21

Molecular Formula: C14H4N2Na2O8/ C14H6N2O8

Kufotokozera: PQQ Disodium Salt 99%; PQQ Acid 99%

Maonekedwe: Reddish lalanje mpaka Reddish Brown Fine Powder.

Kugwiritsa ntchito: Amagwiritsidwa ntchito kwambiri powonjezera zakudya komanso zakudya zopatsa thanzi.

Kusungirako: Kusungidwa pamalo omasuka komanso owuma, pewani ku dzuwa.

Zakudya za Pyrroloquinoline Quinone

PQQ mwachilengedwe imakhalapo muzakudya zambiri zamasamba, zipatso, ndi ndiwo zamasamba (zotsatira), ndipo kuchuluka kwa PQQ kumatha kudziwika muzinthu za soya zofufumitsa, monga kiwifruit, lychee, nyemba zobiriwira, tofu, rapeseed, mpiru, tiyi wobiriwira (camellia), tsabola wobiriwira, sipinachi, ndi zina zambiri.

G.Haug adapeza kuti inali cofactor yachitatu ya redox mu mabakiteriya pambuyo pa nicotinamide ndi flavin (ngakhale adaganiza kuti ndi naphthoquinone). Anthony ndi Zatman adapezanso ma cofactors osadziwika a redox mu ethanol dehydrogenase. Mu 1979, Salisbury ndi anzake komanso Duine ndi anzawo adachotsa maziko abodzawa kuchokera ku methanol dehydrogenase ya dinoflagellates ndikuzindikira kapangidwe kake ka maselo. Adachi ndi anzake adapeza kuti Acetobacter ilinso ndi PQQ.

Njira ya zochita za Pyrroloquinoline Quinone

Pyrroloquinoline quinone (PQQ) ndi molekyu yaying'ono ya quinone, yomwe imakhala ndi redox, imatha kuchepetsa oxidant (antioxidant); kenako imabwezeretsedwanso kukhala mawonekedwe okhazikika ndi glutathione. Zikuwoneka ngati zokhazikika chifukwa zimatha kupitilira masauzande ambiri zisanathe, ndipo ndizatsopano chifukwa zimagwirizana ndi kapangidwe ka mapuloteni a maselo (ma antioxidants ena, ma carotenoids akuluakulu monga beta-carotene ndi astaxanthin, amakhala m'malo enaake a maselo, komwe amasewera kwambiri ma antioxidant maudindo molingana). Chifukwa cha kuyandikira, PQQ ikuwoneka kuti ikuchita gawo pafupi ndi mapuloteni monga carotenoids pama cell membranes.

Ntchito za redox izi zimatha kusintha magwiridwe antchito a protein ndi njira zotumizira ma sign. Ngakhale pali maphunziro ambiri odalirika mu vitro (mitundu yakunja), zotsatira zina zolimbikitsa za PQQ zowonjezera zimakhudzana makamaka ndi kusintha njira zotumizira ma siginali kapena mapindu ake kukhala mitochondria. (Pangani zambiri ndikuwongolera magwiridwe antchito).

Ndi coenzyme mu mabakiteriya (kotero kwa mabakiteriya, ali ngati B-vitamini), koma sakuwoneka kuti akufalikira kwa anthu. Popeza kuti zimenezi sizikukhudza anthu, nkhani ya mu 2003 ya m’magazini yasayansi yotchedwa Nature, inati lingaliro lakuti PQ ndi mankhwala a vitamini ndi lachikale ndipo limaonedwa kuti ndi “chinthu chonga vitamini.”

Mwina chodziwika kwambiri ndi momwe PQQ imakhudzira mitochondria, yomwe imapereka mphamvu (ATP) ndikuwongolera ma cell metabolism. Ofufuza awona kwambiri momwe PPQ imakhudzira mitochondria ndipo adapeza kuti PQQ imatha kuwonjezera kuchuluka kwa mitochondria komanso kupititsa patsogolo mphamvu ya mitochondria. Ichi ndi chifukwa chofunikira chomwe PPQ ndiyothandiza kwambiri. Ma enzyme omwe ali ndi PQQ amadziwika kuti glucose dehydrogenase, mapuloteni a quinoa omwe amagwiritsidwa ntchito ngati sensa ya shuga.

Ubwino wa Pyrroloquinoline Quinone

Kukhala ndi mitochondria pabwino kwambiri ndikofunikira kwambiri kuti mukhale ndi moyo wathanzi kotero kuti mutha kupeza zabwino zambiri mukamamwa ppq. Nazi zina mwazofunikira kwambiri zaubwino wa pyrroloquinoline quinone.

Kuchulukitsa Mphamvu Zamagetsi

Chifukwa mitochondria imapanga mphamvu zama cell, ndipo PQQ imathandiza mitochondria kugwira ntchito bwino, mphamvu m'maselo imawonjezeka lonse; iyi ndi Pyrroloquinoline Quinone mitochondrial mechanism. Mphamvu zama cell zosagwiritsidwa ntchito zimapatutsidwa kupita ku ziwalo zina zathupi. Ngati thupi lanu likusowa mphamvu tsiku lonse, kapena mukumva kutopa kapena kugona, ndiye kuti mphamvu yowonjezera ya PPQ ndiyofunikira kwa inu. Kafukufuku wina adapeza kuti atatenga PQQ, anthu omwe ali ndi vuto lamphamvu anali ndi kutopa kwambiri. Ngati mukuyang'ana china chake chowonjezera mphamvu zanu, PQQ ikhoza kukuthandizani.

Kuchepetsa kuchepa kwa chidziwitso

Ndi chitukuko cha sayansi, asayansi apeza kuti mitsempha kukula factor (NGF) akhoza kukula ndi kuchira. Panthawi imodzimodziyo, PQQ yasonyezedwa kuti ili ndi zotsatira zabwino pa NGF ndikuwonjezera kukula kwa mitsempha ndi nthawi za 40. NGF ndiyofunikira pakupanga ndi kukonza ma neuroni atsopano, ndipo imatha kubwezeretsa ma neuroni owonongeka omwe angalepheretse kugwira ntchito kwachidziwitso. Ma neurons ndi maselo omwe amatumiza uthenga, kotero ubongo wathu umatha kulankhulana pakati pawo ndi ziwalo zina za thupi. Kupititsa patsogolo ubwino ndi kuchuluka kwa ma neuron kumatha kupititsa patsogolo kuzindikira. Chifukwa chake, PQQ ili ndi kusintha kwakanthawi kochepa.

Kuthandizira thanzi la mtima

Pyrroloquinoline quinine imapereka chithandizo cha antioxidant ndi mitochondrial. Kafukufuku wasonyeza kuti PQQ ndi CoQ10 zimathandizira kugwira ntchito kwa myocardial komanso kugwiritsa ntchito bwino kwa oxygen. Pyrroloquinoline quinone imalepheretsa kupsinjika kwa okosijeni kudzera pakukonzanso kwake.

Pyrroloquinoline Quinone Disodium Salt (PQQ): Ubwino, Kagwiritsidwe, ndi Chitsogozo cha Chitetezo

Mawu Oyamba
Pyrroloquinoline Quinone Disodium Salt (PQQ) ndi mtundu wokhazikika, wosungunuka m'madzi wa PQQ, cofactor ya redox yokhala ndi antioxidant katundu. Imapezeka mwachilengedwe muzakudya monga kiwifruit, parsley, ndi tsabola wobiriwira, PQQ imagwiritsidwa ntchito kwambiri muzakudya zopatsa thanzi pama cell ndi ma minyewa. Zoposa 80% zazamalonda zimagwiritsa ntchito mchere wa disodium chifukwa cha kukhazikika kwake komanso kupezeka kwa bioavailability.

Zofunika Kwambiri

• Chilinganizo cha Chemical: C₁₄H₄N₂Na₂O₈ (Kulemera kwake: 374.17)
• Maonekedwe: ufa wofiyira wofiirira mpaka wofiira-lalanje
• Kuyera: ≥98% (HPLC yotsimikizika)
• Kusungunuka: 3 g/L m'madzi pa 25°C
• Shelf Life: Imakhala yokhazikika kwa miyezi 36 ikasungidwa muzotengera zomata, kutali ndi kuwala ndi chinyezi.

Ubwino Wathanzi

1. Imawonjezera Mphamvu Zamagetsi: PQQ imayambitsa mitochondrial biogenesis, kupititsa patsogolo kupanga kwa ATP ndi mphamvu zama cell.
2. Imathandizira Ntchito Yachidziwitso: Maphunziro azachipatala amawonetsa kukumbukira bwino, kusinthasintha kwachidziwitso, komanso kuthamanga kwapamwamba, makamaka mwa achichepere (zaka 20-40).
3. Antioxidant & Neuroprotective Effects: Imasokoneza ma radicals aulere, imachepetsa kupsinjika kwa okosijeni, komanso imathandizira kaphatikizidwe ka mitsempha ya kukula kwa mitsempha (NGF).
4. Cardiovascular Health: Imateteza ku kuwonongeka kwa okosijeni m'mitsempha yamagazi ndikuthandizira kugwira ntchito kwa mtima.
5. Mphamvu Zoletsa Kukalamba: Imakulitsa thanzi la khungu pochepetsa kuwonongeka kwa okosijeni komanso kukonza kaphatikizidwe ka collagen.

Mapulogalamu & Mlingo

• Mawonekedwe Odziwika: Omwe Akulimbikitsidwa Kudya Tsiku ndi Tsiku: 10-20 mg pazaumoyo wamba; Mlingo waukulu (mpaka 40 mg) ungagwiritsidwe ntchito moyang'aniridwa ndi achipatala.
  • Makapisozi / Ma Softgels: 10-20 mg (nthawi zambiri amaphatikizidwa ndi CoQ10 chifukwa cha synergistic zotsatira) .
  • Ufa / Zamadzimadzi: 7-20 mg pa kutumikira, yabwino pazosakaniza zakumwa kapena zakudya zogwira ntchito.
• Kusinthasintha Kwapangidwe:
  • PQQ Mchere wa Disodium: Wosungunuka m'madzi, woyenera makapisozi, mapiritsi, ndi zakumwa za ufa.
  • PQQ Acid: Mafuta osungunuka, abwino kwa ma softgels ndi zakumwa zotsekemera.

Ubwino & Chitetezo

• Kuyesa Kwachipani Chachitatu: Kutsimikiziridwa kuti ndi chiyero (≥98%) ndi zitsulo zotsika kwambiri (kutsogolera ≤0.5 ppm, arsenic ≤1 ppm) .
• Mbiri Yachitetezo: Imadziwika kuti ndi yotetezeka (GRAS) pamilingo yovomerezeka. Funsani dokotala ngati muli ndi pakati, mukuyamwitsa, kapena kumwa mankhwala .
• Kusungirako: Sungani pamalo ozizira, owuma (2–8°C) kuti mukhale bata.

Mfundo zazikuluzikulu

• Magwero Achilengedwe vs. Zowonjezera: Ngakhale PQQ ilipo muzakudya, zowonjezera ndizofunikira kuti mukwaniritse milingo yothandiza pachipatala.
• Mkhalidwe Woyang'anira: Kuvomerezedwa ngati chakudya chatsopano ku EU ndi China, ndikufufuza kosalekeza kuti awonjezere ntchito