Apigenin 98%

Apigenin, as a known bioflavonoid, has been shown to exhibit various biological activities, including antioxidant, anti-inflammatory, antitumor, ant-genotoxic, anti-allergic, neuroprotective, cardioprotective, and antimicrobial.However, One of the most frequent sources of apigenin is celery (Apium graveolens), a marsh plant in the family of Apiaceae that has been cultivated as a vegetable since antiquity. Apigenin is the most extracted nutrient in celery, containing 108 mg apigenin per kg.Apigenin is one of the common dietary flavonoids, which is abundantly found in many fruits, vegetables, and medicinal herbs. It serves various physiological functions, such as antioxidant, potent anti-inflammatory, antiviral activities, antibacterial and blood pressure reduction.

Ingoa Hua: rau Herewi tango Apigenin 98%

Latin Ingoa: Apium graveolens L.

CAS No: 520-36-5

Plant Part Whakamahia: Leaf

Whakauru: Apigenin

Anga matou: Apigenin 98,0% i te HPLC

Tae: Brown ki puehu kōwhai ki kakara āhuatanga, me te reka

Tūnga koiora kua: koiora kua Free

Tarapēke: i roto i te 25kgs pahu muka

Storage: Kia mau ipu āu i raumati, wahi maroke, Puritia atu i te marama kaha

Shelf Life: 24 marama i te rā o te hanga

pānga Anti-puku

Apigenin nui he fatongia mahu'inga i roto i te ārai mate pukupuku i te kukume apoptosis i roto i ngā rārangi pūtau.

mate pukupuku ovarian:

i kitea ētahi rangahau e taea apigenin tautāwhi i te tupu, tini, me te whakawhiti o te ca-ov3 (tangata pūtau pukupuku ovarian); te Kereru reira apoptosis o ca-ov3 i roto i te haapa'oraa i te stasis ngā pūtau pukupuku i roto i te G2 / M wāhanga. pā ana te pānga kei ki wa, me te horopeta.

mate pukupuku Pancreatic:

Ka taea e Apigenin tautāwhi i te tini o ngā pūtau mate pukupuku pancreatic. Apigenin pohe a'era te puku mā te whakaiti i te puna o te kūhuka, i te mea te kai ki runga ki e ora pukupuku pūtau. Haunga, Ka taea e Apigenin whakapai ake i te whai huatanga o te hahau gemcitabine hooraa raau.

Chemo-sensitization

I kitea te reira e i apigenin i roto i te te ihirangi iti te pānga cytotoxic iti, me te kore i taea e häpaingia tangata kanisā myeloid whakapeka (HL-60) pūtau ki apoptosis tōtika. Heoi, ka taea e apigenin whakarei i te pānga inhibitory o cisplatin (DDP) i runga i HL-60 tini pūtau i te whakakotahi ki nohanga rerekē o DDP. Na kia whai Apigenin pānga hahau-sensitization i runga i HL-60; Ka taea hoki e ngä nohanga iti o apigenin whakaiti te ātete o HL-60 pūtau ki apoptosis hahau-piri, e ai kia pā ki te raro-ture o NF-κB me BCL-2. (NF-KB ko te ahua o te pūmua matatini e mana DNA tuhinga, te hanga o cytokines me oranga pūtau: whakawaeheretia BCL2 e i roto i te tinana i roto i te ira BCL2, ko reira te mema taketake o te BCL2 pūmua ture utuafare e Ka taea e whakahaere te mate pūtau)

tiaki ate

Ka taea e Apigenin whakaiti whara ate piri e ischemia-reperfusion i roto i antagonizing lipid peroxidation me te scavenging Radicals free.

Ka taea e Apigenin whakaiti whara ate meinga e te ahotea oxidative tika ki tona antioxidant puai me ngā mahi anti-inflammatory.

Kua whakamatauria ngā pharmacological e apigenin he pānga paruru kitea i runga i ate / hepatocyte whara waipiro-piri, ka pā ana tona tikanga tuatahi te ki te inhibition o whakapuaki CYP2E1 i te ate / hepatocyte.

Aukatia te osteoporosis

Apigenin inhibits osteoblastogenesis, osteoclastogenesis, ka ārai hoki te wheua mate.

Apigenin tiaki wheua kikokiko mā te whakaiti i te wheua mate i roto i te tinana.

Ētahi rangahau e pā ana ki te MC3T3-E1, he aho osteoblast kawainga pūtau i takea mai i Mus musculus (kiore) calvaria, kitea e taea apigenin tautāwhi i te TNF-α, IFN-γ, a ka piri te secretion o te maha cytokines e whakatairanga osteoclast hanganga.

aukati Apigenin hoki te pārōnaki o 3T3-L1 pūtau kawainga adipose ki adipocytes kaha, na reira hëoi te pārōnaki kaitiaki inhibition adipocyte pārōnaki-piri IL-6, MCP-1, hua lectin.

Apigenin inhibits te pārōnaki o osteoclasts i ngā rārangi pūtau RAW264.7 me ka inhibits te hanganga o osteoclasts multinucleated. Ka taea hoki te kia kaha ai te reira i osteoclast apoptosis me tautāwhi i wheua resorption.

Anti-inflammatory me anti-āpitihāora mahi

Apigenin pehi te tukanga mumura, faarahi te taumata IL-10 me normalizes te tawhā oxidative ahotea

Apigenin inhibits cytokines pro-inflammatory me te Kereru te hanga cytokine anti-inflammatory.

Ētahi tuhinga kōrero e faaiti apigenin mumura kikokiko piri e te ahotea oxidative i roto i te kopa e modulating ngā tohu oxidative ahotea, interleukins, tohu toto whākōkī, me whakapuaki o te maha atu whākōkī e hāngai ana.

Ture o te endocrine

i kitea Apigenin taea whakahaere huka toto, hamani thyroid iti hoki, me te whakahaere i lipid peroxidation.It e taea apigenin ake i nga taumata o te taiāki huka me te thyroxine i roto i nga kararehe mate huka, me te whakaiti i te kukū o te huka toto, me te mahi o te kūhuka-6-phosphorylase (G- 6-pase).

whakamuri Apigenin nga pānga o nui haere cholesterol serum, nui haere peroxidation ate lipid (AHW) ka heke ngā mahi o antioxidants pērā i catalase (CAT), me te dismutase superoxide (kohuatia) i roto i nga kararehe alloxan-piri.

I roto i te kararehe ki te huka toto auau, ka taea e hoki apigenin whakaiti cholesterol serum me te ate lipid peroxidation, ka whakapiki ake i te mahi o antioxidants i roto i ngā pūtau.

āhuatanga pharmacological o apigenin

Kua Apigenin kua piri faufaa nui i roto i nga tau tata nei, ka rite ki te kaiwhakatairanga hauora painga i runga i te pūkete o tona tāoke raro tūturu me ona pānga hauora i runga i te wā, versus ngā pūtau mate pukupuku, whakaritea ki ētahi atu flavonoids e pā ana te hanganga. He ko te nuinga o te taunakitanga rangahau kua whakakitea e apigenin he pūmanawa whakaora nui mō te maha mate

taumahi:

-Inhibit te tupu o ngā pūtau mate pukupuku.

pēhanga toto -Lower

-Protects te pūnaha Cardiovascular

moe -Help, raru marino, faaore i irritability

mumura -Resist

osteoporosis -Prevent

pānga -Diuretic.

whakahiato mōtepe -Inhibit.

Taupānga:

-Medicine field, Health care field