Apigenin, as a known bioflavonoid, has been shown to exhibit various biological activities, including antioxidant, anti-inflammatory, antitumor, ant-genotoxic, anti-allergic, neuroprotective, cardioprotective, and antimicrobial.However, One of the most frequent sources of apigenin is celery (Apium graveolens), a marsh plant in the family of Apiaceae that has been cultivated as a vegetable since antiquity. Apigenin is the most extracted nutrient in celery, containing 108 mg apigenin per kg.Apigenin is one of the common dietary flavonoids, which is abundantly found in many fruits, vegetables, and medicinal herbs. It serves various physiological functions, such as antioxidant, potent anti-inflammatory, antiviral activities, antibacterial and blood pressure reduction.
Igama Product: Celery leaf luthathe Apigenin 98%
Igama Latin: Apium graveolens L.
CAS No: 520-36-5
Plant Ingxenye Used: Igqabi
Eziletha: Apigenin
Uvavanyo: Apigenin 98,0% ngo solibalo
Umbala: Brown ku ngumgubo ezimthubi livumba iimpawu kunye nemvakalo
YeMfuzo Ubume: yeMfuzo Free
Ukupakisha: ngo 25kgs imigqomo ifayibha
Storage: Gcina isikhongozeli bengawatyi apha, kwindawo eyomileyo epholileyo, Gcina kude wokukhanya onamandla
Ubude bethuba Life: iinyanga ezingama-24 ukususela kumhla yemveliso
ukusebenza Anti-ithumba
Apigenin ludlala indima ebalulekileyo kuthintelo somhlaza ngokuphembelela apoptosis kwimigca ezahlukeneyo cell.
umhlaza Ovarian:
Abanye uphando kwafunyaniswa ukuba apigenin unako zinqanda ukukhula, ukwanda, kunye nokudluliselwa ca-ov3 (iseli human umhlaza ovarian); eyenza apoptosis ye ca-ov3 nge ngokugcina iiseli umhlaza stasis kwi G2 / M sigaba. Le nguqu ke ezinxulumene ixesha kunye nedosi.
umhlaza pancreatic:
Apigenin kunganqanda kunyebeleziso iiseli zomhlaza pancreatic. Apigenin libangela ukuba ithumba ngokunciphisa umthombo glucose, Leyo yeyona ikukudla apho imihlaza iiseli ubomi. Ngapha koko, Apigenin unako ukuphucula ukusebenza kwe-chemotherapy gemcitabine children.
Chemo-zegazi
Kuye kwafunyaniswa ukuba apigenin kwikhontenti phantsi yaba negalelo cytotoxic ephantsi kwaye ayikwazanga eyenza leukemia yabantu zosulele myeloid (HL-60) iiseli ukuba apoptosis ngempumelelo. Noko ke, apigenin ngoyo isiphumo inhibitory of cisplatin (DDP) kwi-HL-60 iseli proliferation ngexesha lokudibanisa nokuqwalaselwa ezahlukeneyo DDP. Ngoko Apigenin lwazi alubenzi ichemotherapy-zegazi on hl-60; Low lamanani apigenin Unako nokunciphisa ukungawi hl-60 iiseli ukuya ichemotherapy-eyabangelwa apoptosis, nto leyo inokunxulunyaniswa phantsi lommiselo of NF-κB kunye bcl-2. (NF-KB luhlobo protein entsonkothileyo olulawula DNA Ukuloba, imveliso cytokines kunye iseli basinde; BCL2 ufakwe kwi emzimbeni gene BCL2, oko ilungu lokuqala BCL2 iiproteni regulatory usapho ukuba Unokulawula ukufa kweeseli)
ukhuseleko isibindi
Apigenin banciphise ukwenzakala isibindi kubefundisi ischemia-reperfusion nge antagonizing lipid peroxidation kunye ngokudla radicals simahla.
Apigenin kunganciphisa ukwenzakala isibindi okubangelwa ntshikilelo oxidative ngenxa antioxidant zayo ezinamandla kunye nemisebenzi anti-ukudumba.
imifuniselo amayeza ziye zabonisa ukuba apigenin onesiphumo sengathi yokhuselo isibindi / hepatocyte nokwenzakala utywala-olubangelwa, yaye indlela wayo ophambili enxulumene inhibition of CYP2E1 ibinzana esibindini / hepatocyte.
nqanda kwamathambo
Apigenin abangaphangeliyo osteoblastogenesis, osteoclastogenesis, kwaye kunqanda ukulahleka ithambo.
Apigenin ukhusela ijwabu ithambo ngokunciphisa kwamathambo emzimbeni.
Ezinye izifundo ezinxulumene i MC3T3-E1, i umgca osteoblast siphu- iseli evela Mus musculus (mouse) calvaria, wafumanisa ukuba apigenin kunganqanda ukuba TNF-α, IFN-γ, uze emva koko Salukuhla secretion of cytokines eziliqela ezikhuthaza osteoclast Ukwakheka.
Apigenin kwakhona lazi umahluko ka 3T3-L1 iiseli siphu- adipose zibe adipocytes kakhulu, ngoko ziyibuyisela umva le kumahluko umlindi inhibition adipocyte umahluko-olubangelwa IL-6, MCP-1, imveliso lectin.
Apigenin abangaphangeliyo ukuba umahluko of osteoclasts ukusuka imigca kwiseli RAW264.7 uze abangaphangeliyo ukuyilwa osteoclasts multinucleated. Kwakhona eyenza osteoclast apoptosis kwaye zinqanda resorption ithambo.
Anti-ukudumba kwaye anti-oxidant umsebenzi
Apigenin ukhuza inkqubo ukudumba, kwandisa amanqanaba-IL-10 kwaye normalizes i parameters oxidative ntshikilelo
Apigenin abangaphangeliyo cytokines pro-ukudumba kwaye ukhuthaza imveliso cytokine anti-ukudumba.
Abanye ncwadi kubonisa ukuba apigenin kuyancipha izihlunu ukudumba eyabangelwa uxinezelekile oxidative zomzimba ngokuthi modulating abamakishi ezahlukeneyo oxidative ntshikilelo, neeinterleukins, abamakishi enzyme igazi, kunye yokubonisa nezinye enzymes eziliqela ezinxulumeneyo.
WokuLawula yonyango
Apigenin banako ukulawula iswekile yegazi, imphathe lengqula insufficiency kwaye ulawule lipid peroxidation.It kwafunyaniswa ukuba apigenin sandise amanqanaba insulin kunye thyroxine kwizilwanyana seswekile, yaye kuncitshiswe uyondelelwano lwee- iswekile yegazi kunye nomsebenzi glucose-6-phosphorylase (G- 6-Pase).
Apigenin zijikwe iziphumo eyandileyo serum cholesterol, ukwanda isibindi lipid peroxidation (LPO) nokwehla imisebenzi antioxidants ezifana catalase (CAT) kunye dismutase superoxide (bazipheka) izilwanyana alloxan-uqhutyelwe.
Xa izilwanyana eswekile yegazi rhoqo, apigenin Unako nokunciphisa cholesterol serum kunye zesibindi lipid peroxidation, nokwandisa umsebenzi antioxidants eziseleni.
Iipropati kwemithi of apigenin
Apigenin iye yayibaluleke kakhulu apha kwiminyaka yakutshanje, njengoko ndikhuthaze zempilo kuyingenelo ngenxa yetyhefu yayo esezantsi analo kunye neziphumo zayo lwempilo rhoqo xa kuthelekiswa iiseli umhlaza, xa kuthelekiswa namanye flavonoids ezinxulumene ngokokwakheka. Kukho a isambuku ubungqina uphando lubonise apigenin inethuba elikhulu zonyango izifo ezininzi
umsebenzi:
-Inhibit ukukhula iiseli zomhlaza.
uxinzelelo lwegazi -Lower
-Protects nemithambo yegazi
ubuthongo -Help, imizwa uzolile, ukuphelisa ucaphuka
nezilonda -Resist
kwamathambo -Prevent
ukusebenza -Diuretic.
zegazi udibaniso -Inhibit.
isicelo:
-Medicine field, Health care field
Ulwazi ngaphezulu TRB |
||
R sokuqinisekisa egulation | ||
USFDA, ¸cep, HALAL zaseKosher GMP ISO Iziqinisekiso | ||
Quality ezinokuthenjwa | ||
Phantse 20 iminyaka, kumanye amazwe 40 kunye nemimandla, ngaphezulu kwama-2000 iibhetshi eziveliswe TRB ukuba akukho naziphi na iingxaki umgangatho, inkqubo zokuhlanjululwa unique, ukungcola kunye nolawulo ntumbuluko ukuhlangana USP, EP kunye CP | ||
Quality System Comprehensive | ||
|
▲ System Quality Assurance |
√ |
▲ ukulawula Document |
√ |
|
▲ Ukuqinisekisa System |
√ |
|
▲ System Training |
√ |
|
▲ Protocol Internal Audit |
√ |
|
▲ Suppler Audit System |
√ |
|
▲ Equipment Facilities System |
√ |
|
▲ Material Control System |
√ |
|
▲ Production Control System |
√ |
|
▲ Packaging Ukuphawula System |
√ |
|
▲ Laboratory Control System |
√ |
|
▲ Ukuqinisekisa Ulwenziwo System |
√ |
|
▲ Regulatory Affairs System |
√ |
|
ULawulo Wonke Imithombo neenkqubo | ||
kulawulwe zonke izinto ekrwada, izincedisi kunye nokupakishwa materials.Preferred ekrwada izixhobo kunye nezincedisi kunye nezinto zokubopha umthengisi kunye US DMF number.Several abathengisi izinto zokwenza imveliso njengoko nesiqinisekiso sonikezelo. | ||
Amaziko Strong Cooperative ukuxhasa | ||
Institute of Botany / Institution of eziphilayo / Academy of Science and Technology / University |