Apigenin, as a known bioflavonoid, has been shown to exhibit various biological activities, including antioxidant, anti-inflammatory, antitumor, ant-genotoxic, anti-allergic, neuroprotective, cardioprotective, and antimicrobial.However, One of the most frequent sources of apigenin is celery (Apium graveolens), a marsh plant in the family of Apiaceae that has been cultivated as a vegetable since antiquity. Apigenin is the most extracted nutrient in celery, containing 108 mg apigenin per kg.Apigenin is one of the common dietary flavonoids, which is abundantly found in many fruits, vegetables, and medicinal herbs. It serves various physiological functions, such as antioxidant, potent anti-inflammatory, antiviral activities, antibacterial and blood pressure reduction.
Lebitso sehlahisoa: Celery lekhasi ntšang Apigenin 98%
Latin Name: Apium graveolens L.
CAS No: 520-36-5
Semela Karolo Sebelisoa: Leaf
Motsoako: Apigenin
Thlahlobo: Apigenin 98,0% ke HPLC
Mala: Brown ho phofo mosehla le monko o bath le tatso
GMO Status: GMO Free
Paka: ka 25kgs faeba meropa
Storage: Boloka setshelo unopened ka pholile, sebaka omileng, Boloka hole khanya le matla
Raka, athe Bophelo: dikgwedi tse 24 ho tloha letsatsing la ho hlahisoeng
phello e-ba khahlanong le hlahala
Apigenin phetha karolo ea bohlokoa ho thibelo bakeng sa kankere ke ho susumelletsa apoptosis ka mela tse fapa-fapaneng seleng.
bakeng sa kankere popelo:
Lipatlisiso ho ileng ha fumanoa hore apigenin ka thibela metsoako keketseho, keketseho, le phetiso ea tham-ov3 (popelo batho bakeng sa kankere seleng e); e bitsang apoptosis ea tham-ov3 ka ho boloka lisele bakeng sa kankere stasis ka G2 / M mohato. phello ea e amanang le nako le lethal dose.
bakeng sa kankere Pancreatic:
Apigenin ka thibela metsoako ea keketseho ea lisele bakeng sa kankere pancreatic. Apigenin starves hlahala ka ho fokotsa mohloli oa tsoekere, e leng lijo tseo kankere lisele tse phelang ho eona. Ntle ho moo, Apigenin ka ntlafatsa ho atleha ha ho phekolo ea lik'hemik'hale drug- gemcitabine.
Chemo-sensitization
Ho ile ha fumanoa hore apigenin ka dikahare tlaase o ne a tlaase cytotoxic e le hantle 'me ke sa susumelletsa batho hlobaetsang myeloid kankere ea mali (hl la-60) lisele tse ho apoptosis ka katleho. Leha ho le joalo, apigenin ka khona ho ntlafatsa phello inhibitory tsa cisplatin (DDP) ka hl la-60 seleng ea ata ha kopantseng le concentrations e fapaneng ya DDP. Kahoo Apigenin ka 'na na le phekolo ea lik'hemik'hale-sensitization phello hl la-60; concentrations tlaase ea apigenin ka boela fokotsa ho hanyetsa ea hl la-60 lisele tse ho etsoa chemotherapy-hlohlelletsoa apoptosis, o ka amana le fatše-molao oa tsamaiso ea NF-κB le BCL-2. (NF-KB ke mofuta oa protheine e rarahaneng e laolang DNA mongwalollo, tlhahiso ea ea tse ling le ho pholoha a ka cell; BCL2 e khouthollotsweng 'meleng ka BCL2 phatsa ea lefutso, ho ke setho pele tsa BCL2 taolo liprotheine lelapa hore ka ho laola lefu seleng e)
tšireletso ea sebete
Apigenin ka fokotsa ntsa kotsi sebete hlohlelletsoa ke ischemia-reperfusion ka antagonizing lipid peroxidation le scavenging mahala radicals.
Apigenin ka fokotsa ntsa kotsi sebete bakoang ke khatello ea kelello oxidative ka lebaka la ho antioxidant lona matla le mesebetsi-ba khahlanong le a hlabang.
Liteko diokobatsi ipakile hore apigenin e na le phello e bonahalang eka e sireletsang ka ho noa joala-hlohlelletsoa mo ntša kotsi sebete / hepatocyte, 'me mochine tsela e ikhethang e amana le thibelo ya CYP2E1 polelo e reng ka sebete / hepatocyte.
thibela osteoporosis
Apigenin thibela osteoblastogenesis, osteoclastogenesis, 'me hape ho thibela ho lahleheloa ke masapo.
Apigenin sireletsa lesapo dinama tse nyenyane tse ka ho fokotsa ho lahleheloa ke lesapo mele.
Ba bang ba lithuto tsa amana le MC3T3-E1, e osteoblast selelekela seleng ea mola tswang Mus musculus (toeba) calvaria, fumana hore apigenin ka thibela metsoako e TNF-α, IFN-γ, ebe susumelletsa secretion ea ea tse ling tse 'maloa tseo ho kgothaletsa osteoclast sebopeho.
Apigenin hape thibang le khethollo ea ba 3T3-L1 lisele tse adipose selelekela ka adipocytes ka matla, ka hona inhibiting le khethollo ea mohlanka oa thibelo adipocyte khethollo ea-hlohlelletsoa IL-6, MCP-1, lectin sehlahisoa.
Apigenin thibela le khethollo ea ba osteoclasts tloha RAW264.7 mela sele le ka nako eo thibela sebopeho sa osteoclasts multinucleated. Ho ka boetse ha susumelletsa osteoclast apoptosis le thibela metsoako lesapo resorption.
-Ba khahlanong le a hlabang le-ba khahlanong le oxidant mosebetsi
Apigenin thibelang tshebetso ho ruruha, eketsa maemo IL-10 le normalizes ea entsprechen khatello ea kelello oxidative
Apigenin thibela ea tse ling lan-a hlabang le bitsang le-ba khahlanong le a hlabang cytokine tlhahiso.
Ba bang ba lingoliloeng fana ka maikutlo a hore apigenin alleviates ruruha dinama tse nyenyane tse hlohlelletsoa ke ho imeloa kelellong oxidative ka lisele tse ka modulating batshwai tse fapa-fapaneng oxidative khatello ea kelello, interleukins, batshwai mali potlakisang tsebetso ea lik'hemik'hale, 'me pontšo ea enzyme tse ling tse' maloa tse amanang.
Molao oa tsamaiso ea endocrine
Apigenin ka laola tsoekere e maling, tšoara thyroid insufficiency le ho laola lipid peroxidation.It ho ile ha fumanoa hore apigenin ka eketsa maemo a ka insulin le thyroxine liphoofolo le lefu la tsoekere, 'me fokotseha ea mahloriso ea tsoekere mali le mosebetsi oa tsoekere-6-phosphorylase (G- 6-Pase).
Apigenin fetola liphello tsa eketseha serum k'holeseterole, e ile ea eketseha sebete lipid peroxidation (LPO) le fokotseha mesebetsi ea antioxidants kang catalase (Cat) le superoxide dismutase (SOD) liphoofolo alloxan-hlohlelletsoa.
Liphoofolo le tsoekere mali kamehla, apigenin ka boela fokotsa serum k'holeseterole le sebete lipid peroxidation, 'me eketsa mosebetsi oa antioxidants ka liseleng.
Diokobatsi thepa ea apigenin
Apigenin e se khomaretse bohlokoa haholo lilemong tsa morao tjena, e le molemo mohlohlelletsi bophelo ka lebaka la toxicity lona tlaase sebōpeho sa motheo sa le liphello tsa eona tse bophelo ka kamehla e bapisiwa le lisele tse kankere, ha e bapisoa le flavonoids tse ling structurally amanang. Ho na le e ka bongata ha bopaki lipatlisiso tse bontšitseng apigenin o moholo phekolo monyetla oa mafu a tse ngata
Function:
-Inhibit kgolo ya lisele tse kankere.
-Lower khatello ea mali
-Protects tsamaiso la pelo
-Help robala, e nang le khutso methapo, felisa teneha
-Resist ruruha
-Prevent osteoporosis
-Diuretic sebediswa.
-Inhibit platelet aggregation.
kopo:
-Medicine field, Health care field
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