Apigenin 98%

Apigenin, as a known bioflavonoid, has been shown to exhibit various biological activities, including antioxidant, anti-inflammatory, antitumor, ant-genotoxic, anti-allergic, neuroprotective, cardioprotective, and antimicrobial.However, One of the most frequent sources of apigenin is celery (Apium graveolens), a marsh plant in the family of Apiaceae that has been cultivated as a vegetable since antiquity. Apigenin is the most extracted nutrient in celery, containing 108 mg apigenin per kg.Apigenin is one of the common dietary flavonoids, which is abundantly found in many fruits, vegetables, and medicinal herbs. It serves various physiological functions, such as antioxidant, potent anti-inflammatory, antiviral activities, antibacterial and blood pressure reduction.

Product Name: rwaning celery extract Apigenin 98%

Jeneng Latin: Apium graveolens L.

CAS No: 520-36-5

Tanduran Part Digunakna: Leaf

Bakal: Apigenin

Pengujian kadar logam: Apigenin 98,0% dening HPLC

Warna: Coklat kanggo wêdakakêna kuning karo ambu ora enak karakteristik lan rasa

Status GMO: GMO Free

Packing: ing 25kgs drum serat

Storage: Tansah wadhah unopened ing kelangan, garing Panggonan, Tansah adoh saka cahya kuwat

Beting urip: 24 sasi saka tanggal produksi

efek anti-tumor

Apigenin peran penting ing Nyegah kanker dening mengaruhi apoptosis ing garis macem-macem sel.

kanker ovarium:

Sawetara riset ketemu sing apigenin bisa nyandhet wutah, tambahan, lan transfer ca-ov3 (sel kanker ovarium manungsa); iku ngindhuksi apoptosis saka ca-ov3 liwat tetep sel kanker stasis ing G2 phase / M. Ing efek related kanggo wektu lan dosis.

kanker pankreas:

Apigenin bisa nyandhet proliferasi sèl kanker pankreas. Apigenin starves tumor dening ngurangi sumber glukosa, kang pangan kang kanker sel urip. Kejabi, Apigenin bisa nambah efektifitas saka kemoterapi gemcitabine drug-.

Chemo-sensitization

Sampeyan iki ketemu sing apigenin ing isi kurang wis efek cytotoxic kurang lan ora bisa panggawe manungsa leukemia myeloid leukemia (ML-60) sel kanggo apoptosis èfèktif. Nanging, apigenin bisa nambah efek nyegati saka cisplatin (DDP) ing Samsung ML-60 proliferasi sèl nalika nggabungke karo konsentrasi beda DDP. Dadi Apigenin uga duwe pengaruh kemoterapi-sensitization ing Samsung ML-60; kurang konsentrasi saka apigenin uga bisa ngurangi resistance saka Samsung ML-60 sel kanggo apoptosis kemoterapi-mlebu, kang bisa gegandhengan karo mudhun-angger NF-κB lan Bcl-2. (NF-KB jenis Komplek protein sing kontrol transkripsi DNA, produksi sitokin lan kaslametané sel; BCL2 wis dikode ing awak liwat gene BCL2, iku anggota asli BCL2 protein peraturan kulawarga sing bisa ngatur pati sel)

pangayoman ati

Apigenin bisa ngurangi bundhas ati mlebu dening iskemia-reperfusion liwat antagonizing peroksidasi lipid lan scavenging radikal bebas.

Apigenin bisa ngurangi bundhas ati disebabake stres oksidatif amarga antioksidan kuat lan aktivitas anti-natoni.

nyobi farmakologis wis mbuktekaken bilih apigenin duwe pengaruh protèktif nyoto ing bundhas ati / hépatosit alkohol-mlebu, lan mekanisme utamanipun gegandhengan karo pencegahan expression CYP2E1 ing ati / hépatosit.

nyegah osteoporosis

Apigenin nyegah osteoblastogenesis, osteoclastogenesis, lan uga ngalangi mundhut balung.

Apigenin nglindhungi tissue balung dening ngurangi mundhut balung ing awak.

Sawetara studi pranala menyang MC3T3-E1, baris sel ngisaratke osteoblast asalé saka Mus musculus (mouse) calvaria, ketemu sing apigenin bisa nyandhet TNF-α, IFN-γ, lan banjur mlebu metune saka saperangan gedhé sitokin sing ningkataké tatanan osteoclast.

Apigenin uga isin diferensiasi saka 3T3-L1 sel adipose ngisaratke menyang adipocytes banget, mulane nyandhet diferensiasi tekone pencegahan adipocyte diferensiasi-mlebu IL-6, MCP-1, produk lectin.

Apigenin nyegah diferensiasi saka osteoclasts saka garis sel RAW264.7 banjur nyegah tatanan osteoclasts multinucleated. Uga bisa ngindhuksi apoptosis osteoclast lan nyandhet resorption balung.

Anti-natoni lan anti-oxidant kegiatan

Apigenin restrains proses inflammation, mundhak IL-10 tingkat lan normalizes paramèter stres oksidatif

Apigenin nyegah sitokin pro-natoni lan ngindhuksi anti-natoni produksi sitokin.

Sawetara sastra tabet sing apigenin alleviates inflammation tissue mlebu dening stres oksidatif ing jaringan dening modulating macem-macem pelaku oksidasi kaku, interleukins, pelaku enzim getih, lan ekspresi saperangan enzim liyane sing gegandhengan.

Peraturan endokrin

Apigenin bisa ngatur gula getih, nambani insufficiency toroida lan ngontrol peroxidation.It lipid ketemu sing apigenin bisa nambah kadhar insulin lan thyroxine ing kéwan diabetes, lan ngurangi konsentrasi saka gula getih lan kegiatan saka glukosa-6-phosphorylase (G- 6-pase).

Apigenin ngowahi efek saka tambah kolesterol serum, tambah peroksidasi lipid ati (LPO) lan ngurangi aktivitas antioksidan kayata catalase (CAT) lan dismutase superoksida (sod) ing kéwan alloxan-mlebu.

Ing kéwan karo gula getih biasa, apigenin uga bisa ngurangi kolesterol serum lan peroksidasi lipid ati, lan nambah kegiatan saka antioksidan ing sel.

situs farmakologis saka apigenin

Apigenin wis ditempelake wigati ing taun anyar, minangka promosi kesehatan ono gunane ing akun keracunan kasirat ngisor lan efek kasarasan ing biasa mungsuh sel kanker, dibandhingake karo liyane flavonoid related structurally. Ana sing akeh saka bukti riset sing wis ditampilake apigenin wis potensial babagan pengobatan gedhe kanggo akeh penyakit

fungsi:

-Inhibit wutah saka sel kanker.

meksa getih -Lower

-Protects sistem jantung

turu -Help, syaraf kalem, ngilangke irritability

inflammation -Resist

osteoporosis -Prevent

efek -Diuretic.

pengumpulan trombosit -Inhibit.

aplikasi:

-Medicine field, Health care field