Apigenin 98%

Apigenin, as a known bioflavonoid, has been shown to exhibit various biological activities, including antioxidant, anti-inflammatory, antitumor, ant-genotoxic, anti-allergic, neuroprotective, cardioprotective, and antimicrobial.However, One of the most frequent sources of apigenin is celery (Apium graveolens), a marsh plant in the family of Apiaceae that has been cultivated as a vegetable since antiquity. Apigenin is the most extracted nutrient in celery, containing 108 mg apigenin per kg.Apigenin is one of the common dietary flavonoids, which is abundantly found in many fruits, vegetables, and medicinal herbs. It serves various physiological functions, such as antioxidant, potent anti-inflammatory, antiviral activities, antibacterial and blood pressure reduction.

Ọja orukọ: Seleri bunkun jade Apigenin 98%

Latin Name: Apium graveolens L.

CAS No: 520-36-5

Plant Apá lo: bunkun

Eroja: Apigenin

Itupalẹ: Apigenin 98,0% nipa HPLC

Awọ: Brown to ofeefee lulú pẹlu iwa awọn wònyí ati ki o lenu

GMO Ipo: GMO Free

Iṣakojọpọ: ni 25kgs fiber ilu ti n lu

Ibi: Jeki eiyan unopened ni itura, gbẹ ibi, Jeki kuro lati lagbara ina

Selifu Life: 24 osu lati ọjọ ti gbóògì

Anti-tumo si ipa

Apigenin yoo ẹya awọn ibaraẹnisọrọ ni ipa ni akàn idena nipa inducing apopitosisi ni orisirisi cell ila.

Ọjẹ akàn:

Diẹ ninu awọn iwadi ti ri wipe apigenin le dojuti awọn idagba, afikun, ati gbigbe ti ca-ov3 (eda eniyan ọjẹ akàn cell); ti o fa apopitosisi ti ca-ov3 nipasẹ fifi awọn akàn ẹyin stasis ni G2 / M alakoso. Awọn ipa ti wa ni jẹmọ si akoko ati iwọn lilo.

Nkan inu akàn:

Apigenin le dojuti awọn afikun ti nkan inu akàn ẹyin. Apigenin starves awọn tumo nipa atehinwa awọn orisun ti glukosi, eyi ti o jẹ onjẹ lori eyi ti awọn aarun ẹyin gbe. Yato si, Apigenin le mu ndin ti awọn kimoterapi drug- gemcitabine.

Chemo-ifoyeyeni

O ti ri pe apigenin ni kekere akoonu ní a kekere cytotoxic ipa ati ki o ko le jeki eda eniyan ńlá myeloid lukimia (HL-60) ẹyin lati apopitosisi fe ni. Sibẹsibẹ, apigenin le mu awọn adinilọwọ ipa ti cisplatin (DDP) lori HL-60 cell afikun nigba ti apapọ pẹlu o yatọ si awọn ifọkansi ti DDP. Ki Apigenin le ni kimoterapi-ifoyeyeni ipa lori HL-60; Low awọn ifọkansi ti apigenin tun le din resistance ti HL-60 ẹyin lati kimoterapi-induced apopitosisi, eyi ti o le wa ni jẹmọ si isalẹ-ilana ti NF-κB ati BCL-2. (NF-KB ni a irú ti amuaradagba eka ti išakoso DNA transcription, isejade ti saitokinisi ati sẹẹli iwalaaye; BCL2 ti wa ni ti yipada ninu ara nipasẹ awọn BCL2 pupọ, o jẹ atilẹba egbe ti awọn BCL2 ilana awọn ọlọjẹ ebi ti le fiofinsi cell iku)

ẹdọ Idaabobo

Apigenin le din ẹdọ ipalara da sile nipa ischemia-reperfusion nipasẹ antagonizing ora peroxidation ati scavenging free awọn ti ipilẹṣẹ.

Apigenin le din ẹdọ ipalara ṣẹlẹ nipasẹ oyi wahala nitori awọn oniwe-agbara ẹda ati egboogi-iredodo akitiyan.

Pharmacological adanwo ti safihan pe apigenin ni o ni ohun kedere aabo ipa lori oti-induced ẹdọ / hepatocyte ipalara, ati awọn oniwe-jc siseto wa ni jẹmọ si itiju ti CYP2E1 ikosile ninu ẹdọ / hepatocyte.

se osteoporosis

Apigenin lọna osteoblastogenesis, osteoclastogenesis, ki o si tun idilọwọ awọn egungun pipadanu.

Apigenin aabo fun egungun àsopọ nipa atehinwa egungun pipadanu ninu ara.

Diẹ ninu awọn ẹrọ jẹmọ si MC3T3-E1, ohun osteoblast ṣaaju cell ila yo lati to musculus (Asin) calvaria, ri wipe apigenin le dojuti awọn TNF-α, IFN-γ, ati ki o da awọn yomijade ti awọn orisirisi saitokinisi ti o se igbelaruge osteoclast Ibiyi.

Apigenin tun inhibited awọn yiyatọ ti 3T3-L1 adipose ṣaaju ẹyin sinu adipocytes strongly, nitorina inhibiting awọn yiyatọ baalu itiju adipocyte yiyatọ-induced IL-6, MCP-1, lectin ọja.

Apigenin lọna awọn yiyatọ ti osteoclasts lati RAW264.7 cell ila ati ki o si lọna awọn Ibiyi ti multinucleated osteoclasts. O tun le jeki osteoclast apopitosisi ki o si dojuti egungun resorption.

Egboogi-iredodo ati egboogi-oxidant aṣayan iṣẹ-ṣiṣe

Apigenin ọlọkàn awọn igbona ilana, mu ki awọn IL-10 awọn ipele ati sipo awọn ti oyi wahala sile

Apigenin lọna pro-iredodo saitokinisi ati fa awọn egboogi-iredodo cytokine gbóògì.

Diẹ ninu awọn litireso ni imọran wipe apigenin din àsopọ iredodo da sile nipa oyi wahala ni tissues nipa modulating orisirisi ti oyi wahala asami, interleukins, ẹjẹ henensiamu asami, ati ikosile ti awọn orisirisi miiran ni ibatan ensaemusi.

Ilana ti endocrine

Apigenin le fiofinsi ẹjẹ suga, toju tairodu insufficiency ki o si dari ora peroxidation.It ti ri wipe apigenin le mu awọn ipele ti hisulini ati thyroxine ni dayabetik eranko, ati ki o dinku awọn fojusi ti ẹjẹ suga ati awọn aṣayan iṣẹ ti glukosi-6-phosphorylase (G- 6-Pase).

Apigenin ifasilẹ awọn awọn ipa ti pọ omi idaabobo, pọ ẹdọ ora peroxidation (LPO) ati din ku akitiyan ti antioxidants bi catalase (nran) ati superoxide dismutase (Sod) ni alloxan-induced eranko.

Ninu eranko pẹlu awọn ẹjẹ suga, apigenin tun le din omi idaabobo ati ẹdọ ora peroxidation, ki o si mu awọn aṣayan iṣẹ ti antioxidants ni ẹyin.

Pharmacological-ini ti apigenin

Apigenin ti a ti so nla pataki ni to šẹšẹ years, bi awọn kan anfani ti ilera olugbeleke lori iroyin ti awọn oniwe-kekere ojulowo oro ati awọn oniwe-ilera ipa lori deede dipo akàn ẹyin, akawe pẹlu awọn miiran structurally jẹmọ flavonoids. Nibẹ ni a olopobobo ti iwadi eri ti o ti han apigenin ni o ni nla mba pọju fun ọpọlọpọ awọn arun

iṣẹ:

-Inhibit ni idagba ti akàn ẹyin.

-Lower ẹjẹ titẹ

-Protects ẹjẹ eto

-Help orun, tunu ara, imukuro irritability

-Resist iredodo

-Prevent osteoporosis

-Diuretic ipa.

-Inhibit adeepa-ẹjẹ alaropo.

ohun elo:

-Medicine field, Health care field