Ihe karịrị 98%

Apigenin, as a known bioflavonoid, has been shown to exhibit various biological activities, including antioxidant, anti-inflammatory, antitumor, ant-genotoxic, anti-allergic, neuroprotective, cardioprotective, and antimicrobial.However, One of the most frequent sources of apigenin is celery (Apium graveolens), a marsh plant in the family of Apiaceae that has been cultivated as a vegetable since antiquity. Apigenin is the most extracted nutrient in celery, containing 108 mg apigenin per kg.Apigenin is one of the common dietary flavonoids, which is abundantly found in many fruits, vegetables, and medicinal herbs. It serves various physiological functions, such as antioxidant, potent anti-inflammatory, antiviral activities, antibacterial and blood pressure reduction.

Product aha: Celery akwukwo wepụ Apigenin 98%

Latin aha: Apium graveolens L.

CAS No: 520-36-5

Osisi Part Ji: Leaf

Mgwa: Apigenin

Nnwale: Apigenin 98,0% site HPLC

Agba: Brown na-acha odo odo powder na e ji mara isi na uto

GMO Status: GMO Free

Mbukota: na 25kgs eriri rụọ

Nchekwa: Nọgidenụ na akpa unopened na jụụ, akọrọ ebe, na-pụọ ike ìhè

Adịghị adị Life: 24 ọnwa si ụbọchị nke mmepụta

Anti-akpụ mmetụta

Apigenin arụ dị oké mkpa ọrụ na cancer mgbochi site n'ime apoptosis dị iche iche cell e.

Ovarian cancer:

Nnyocha ụfọdụ chọpụtara na apigenin ike inhibit uto, proliferation, na nyefe nke ca-ov3 (mmadụ ovarian cancer cell); ọ induces apoptosis nke ca-ov3 site n'idebe cancer mkpụrụ ndụ stasis na G2 / M na-adọ. Mmetụta na-metụtara oge na dose.

Pancreatic cancer:

Apigenin nwere ike inhibit proliferation nke pancreatic cancer mkpụrụ ndụ. Apigenin akwara ad i obere ngwọta site na mbenata isi iyi nke glucose, nke bụ nri na nke ọrịa cancer mkpụrụ ndụ na-ebi ndụ. E wezụga, Apigenin nwere ike melite arụmọrụ nke na-anara ọgwụ drug- gemcitabine.

Chemo-uche

Ọ hụrụ na apigenin na ala ọdịnaya nwere a ala cytotoxic mmetụta na ike ime ka ụmụ mmadụ na nnukwu myeloid leukemia (HL-60) mkpụrụ ndụ apoptosis irè. Otú ọ dị, apigenin nwere ike welie inhibitory mmetụta nke cisplatin (DDP) on HL-60 cell proliferation mgbe na ijikọta dị iche iche kasịnụ nke DDP. Ya mere Apigenin nwere ọgwụ-uche mmetụta HL-60; Low kasịnụ nke apigenin nwekwara ike belata ndị na-eguzogide HL-60 mkpụrụ ndụ na-anara ọgwụ na-akpata apoptosis, nke nwere ike metụtara ala-iwu nke NF-κB na BCL-2. (NF-KB bụ ụdị protein mgbagwoju na akara DNA transcription, na mmepụta nke cytokines na cell lanarị; BCL2 na-koodu ke idem site BCL2 site n'usoro, ọ bụ onye mbụ so na BCL2 usoro iwu na-edozi ezinụlọ na nwere ike mezie cell ọnwụ)

imeju nchedo

Apigenin ike belata imeju mmerụ rata site ischemia-reperfusion site ekwugide lipid peroxidation na scavenging free radicals.

Apigenin ike belata imeju mmerụ mere site oxidative nchegbu ruru ya nwere ike antioxidant na mgbochi mkpali eme.

Pharmacological nwere gaara egosi na apigenin nwere ihe yiri na-echebe mmetụta na mmanya na-akpata imeju / hepatocyte ọjọọ, na ya bụ isi usoro a metụtara mgbochi nke CYP2E1 okwu imeju / hepatocyte.

gbochie osteoporosis

Apigenin egbochi osteoblastogenesis, osteoclastogenesis, na-egbochi ọkpụkpụ ọnwụ.

Apigenin echebe ọkpụkpụ anụ ahụ site na mbenata ọkpụkpụ ọnwụ ke idem.

Ụfọdụ nnyocha metụtara MC3T3-E1, ihe osteoblast precursor cell akara ewepụtara mus musculus (òké) calvaria, chọpụtara na apigenin nwere ike inhibit TNF-α, IFN-γ, na mgbe ahụ mere ka secretion nke ọtụtụ cytokines na-akwalite osteoclast guzobere.

Apigenin nwekwara gbochie na iche nke 3T3-L1 adipose precursor mkpụrụ ndụ n'ime adipocytes ike, ya mere inhibiting na iche na-eje ozi mgbochi adipocyte iche na-akpata IL-6, MCP-1, lectin ngwaahịa.

Apigenin egbochi iche nke osteoclasts si RAW264.7 cell edoghi na mgbe na-egbochi guzobe multinucleated osteoclasts. Ọ nwekwara ike ime ka osteoclast apoptosis na inhibit ọkpụkpụ resorption.

Mgbochi mkpali na mgbochi oxidant ọrụ

Apigenin egbochi mbufụt usoro, enwekwu IL-10 etoju na apụta na oxidative nchegbu parameters

Apigenin egbochi pro mkpali cytokines na induces ndị mgbochi mkpali cytokine mmepụta.

Akwụkwọ ụfọdụ na-egosi na apigenin ebelata anụ ahụ mbufụt rata site oxidative nchegbu na nsụkọrọ site modulating iche iche oxidative nchegbu nrịbama, interleukins, ọbara enzyme nrịbama, na okwu nke ọtụtụ ndị ọzọ yiri enzymes.

Regulation nke endocrine

Apigenin nwere ike mezie ọbara sugar, na-emeso thyroid insufficiency na na-ejikwa lipid peroxidation.It chọpụtara na apigenin ike dịkwuo etoju nke insulin na thyroxine na-arịa ọrịa shuga na ụmụ anụmanụ, na ibelata ịta nke ọbara sugar na ọrụ nke glucose-6-phosphorylase (G- 6-Pase).

Apigenin nwesịrị mmetụta nke ụba ọbara cholesterol, mụbara imeju lipid peroxidation (LPO) na-ebelata-eme nke antioxidants dị ka catalase (Cat) na superoxide dismutase (SOD) na alloxan na-akpata ụmụ anụmanụ.

Na ụmụ anụmanụ na mgbe ọbara sugar, apigenin nwekwara ike belata ọbara cholesterol na imeju na lipid peroxidation, ma na-amụba ọrụ nke antioxidants na mkpụrụ ndụ.

Pharmacological Njirimara nke apigenin

Apigenin e mmasị oké mkpa na-adịbeghị anya, dị ka a bara uru ahụ ike ume n'ihi ya ala intrinsic toxicity na ya ike na mmetụta na-mgbe nile vesos cancer mkpụrụ ndụ, tụnyere ndị ọzọ structurally metụtara flavonoids. E nwere na a nnukwu nke nnyocha na-egosi na egosiwo apigenin nwere oké ọgwụgwọ nwere maka ọtụtụ ọrịa

Function:

-Inhibit uto nke ndụ nke kansa.

-Lower ọbara mgbali

-Protects na obi usoro

-Help ụra, udo akwara, kpochapụ ogwe

-Resist mbufụt

-Prevent osteoporosis

-Diuretic mmetụta.

-Inhibit platelet aggregation.

ngwa:

-Medicine field, Health care field