I-Apigenin 98%

Apigenin, as a known bioflavonoid, has been shown to exhibit various biological activities, including antioxidant, anti-inflammatory, antitumor, ant-genotoxic, anti-allergic, neuroprotective, cardioprotective, and antimicrobial.However, One of the most frequent sources of apigenin is celery (Apium graveolens), a marsh plant in the family of Apiaceae that has been cultivated as a vegetable since antiquity. Apigenin is the most extracted nutrient in celery, containing 108 mg apigenin per kg.Apigenin is one of the common dietary flavonoids, which is abundantly found in many fruits, vegetables, and medicinal herbs. It serves various physiological functions, such as antioxidant, potent anti-inflammatory, antiviral activities, antibacterial and blood pressure reduction.

Igama lomkhiqizo: Isilimo esidliwayo esinamagatsha anamanzi leaf kukhishwe Apigenin 98%

Latin igama: Apium graveolens L.

CAS Ayikho: 520-36-5

Plant Ingxenye esetshenzisiwe: Leaf

Isithako: Apigenin

Yokuncwaninga izinsimbi kanye namakhemikhali: Apigenin 98,0% ngo HPLC

Umbala: Brown luthuli ephuzi isici iphunga nokunambitheka

Isimo GMO: GMO Mahhala

Ukupakisha: e 25kgs fibre izigubhu

Isigcini: Gcina esitsheni lizihlalele e cool, endaweni eyomile, Dedani ekukhanyeni okunamandla

Shelf Life: izinyanga 24 kusukela ngosuku ukukhiqizwa

Anti-isimila umphumela

Apigenin ufeza indima ebalulekile ekuvimbeleni umdlavuza ngokuyenga apoptosis e ahlukahlukene cell imigqa.

umdlavuza wesibeletho:

Olunye ucwaningo kwatholakala ukuthi apigenin kungase kuthiye ukukhula, ayanda, futhi ukudluliswa ca-ov3 (womuntu wesibeletho umdlavuza cell); eyenza apoptosis ka ca-ov3 ngokusebenzisa ukugcina amangqamuzana omdlavuza stasis e G2 / M isigaba. Umthelela ihlobene isikhathi umthamo.

umdlavuza pancreatic:

Apigenin singavimbela ekwandeni amangqamuzana omdlavuza pancreatic. Apigenin unciphise isimila ngokunciphisa umthombo glucose, okuyinto ukudla lapho umdlavuza amaseli baphile. Ngaphandle kwalokho, Apigenin kungaba ncono kusebenta kahle ngekhemikhali gemcitabine drug-.

Chemo-sensitization

Kwatholakala ukuthi apigenin kokuqukethwe ongaphakeme saba nethonya ongaphakeme cytotoxic futhi ayikwazanga ntombazane womuntu acute wegazi myeloid (hl-60) amaseli ukuze apoptosis ngempumelelo. Nokho, apigenin kungaba ngcono umphumela inhibitory ka cisplatin (DDP) ku hl-60 cell ayanda kanti ngokuhlanganisa ne lokuhlala ezahlukene DDP. Ngakho Apigenin kungase kudingeke nokwelashwa ngamakhemikhali-sensitization nomthelela hl-60; lokuhlala Eliphansi apigenin Ungase futhi unciphise ukumelana hl-60 ukuba amangqamuzana enze ngendlela apoptosis nokwelashwa ngamakhemikhali olubangelwa, okungase kuhlobane phansi-ukulawulwa NF-κB futhi BCL-2. (NF-KB uhlobo wamaprotheni eziyinkimbinkimbi elawula DNA umbhalo, ukukhiqizwa kwanoma cytokines naweselula sokusinda; BCL2 ufakwe emzimbeni ngokusebenzisa isakhi sofuzo BCL2, kuba ilungu okuqala eNhlangano BCL2 amaprotheni zokulawula umndeni ukuthi ungakwazi ukulawula yokufa kwamangqamuzana engokwemvelo)

Ukuvikelwa isibindi

Apigenin kunganciphisa isibindi ukulimala esibangelwa ischemia-reperfusion ngokusebenzisa yizitha lipid peroxidation futhi sizobona radicals khulula.

Apigenin kunganciphisa isibindi ukulimala nawukucindezeleka oxidative ngenxa antioxidant zalo ezinamandla nemisebenzi ethile eqeda ukuvuvukala.

ucwaningo kwemithi iye yafakazela ukuthi apigenin kuyalithinta sobala zokuzivikela ku utshwala olubangelwa isibindi / hepatocyte ukulimala, futhi indlela yayo eyinhloko ezihlobene okusithiyayo of CYP2E1 Inkulumo esibindini / hepatocyte.

ekuvimbeleni ukukhumuzeka kwamathambo

Apigenin kuvimbela osteoblastogenesis, osteoclastogenesis, futhi kuvimbela amathambo ewohloka.

Apigenin ivikela ithambo izicubu ngokunciphisa kwamathambo emzimbeni.

Ezinye izifundo ezihlobene MC3T3-E1, ulayini osteoblast eyandulela iseli ethathwe Mus musculus (igundane) calvaria, wathola ukuthi apigenin singavimbela TNF-α, IFN-γ, bese wayenga uketshezi of cytokines eziningana ekhuthaza osteoclast kumiswa.

Apigenin futhi engasenamahloni le kwamangqamuzana ka 3T3-L1 eyandulela adipose amaseli ku adipocytes kakhulu, ngakho-ke ezivimbela kwamangqamuzana isikhonzi okusithiyayo adipocyte kwamangqamuzana olubangelwa IL-6, i-MCP-1, lectin umkhiqizo.

Apigenin kuvimbela kwamangqamuzana ka osteoclasts kusukela RAW264.7 cell imigqa bese kuvimbela ukwakheka osteoclasts multinucleated. Ingase futhi ntombazane osteoclast apoptosis futhi zivimbele ithambo resorption.

Anti-inflammatory anti-oxidant umsebenzi

Apigenin ukhuza inqubo ukuvuvukala, kwandisa amazinga IL-10 futhi normalizes nemingcele oxidative ukucindezeleka

Apigenin kuvimbela cytokines pro ukuvuvukala kanye eheha ukukhiqizwa cytokine eqeda ukuvuvukala.

Ezinye izincwadi kusikisela ukuthi apigenin kuyakunciphisa izicubu ukuvuvukala esibangelwa ukucindezeleka oxidative ezicutshini ngu modulating oxidative ukucindezeleka nakomaka ahlukahlukene, interleukin, enzyme igazi omaka, futhi inkulumo ezinye enzyme eziningana ezihlobene.

WokuLawula endocrine

Apigenin ungakwazi ukulawula kashukela, aphathe yegilo esingamahlalakhona futhi ulawule lipid peroxidation.It kwatholakala ukuthi apigenin kungase kwandise amazinga insulin kanye thyroxine ezilwaneni sikashukela, bese wehlise lokuhlushwa kashukela futhi umsebenzi glucose-6-phosphorylase (G- 6-Pase).

Apigenin kuhlehlisiwe imithelela anda serum cholesterol, kukhuphuke isibindi lipid peroxidation (LPO) futhi kwehle imisebenzi Antioxidants ezifana catalase (CAT) kanye dismutase superoxide (wapheka) e izilwane alloxan olubangelwa.

Ezilwaneni ne kashukela njalo, apigenin Ungase futhi kuncishiswe cholesterol serum futhi isibindi lipid peroxidation, futhi sandise umsebenzi Antioxidants kumaseli.

izakhiwo kwemithi ye apigenin

Apigenin iye enamathiselwe ukubaluleka okukhulu eminyakeni yamuva, njengoba kuzuzisa impilo umgqugquzeli ngenxa ubuthi bayo eziwumgogodla ephansi futhi imiphumela yempilo yayo ku njalo kuqhathaniswa amangqamuzana omdlavuza, uma iqhathaniswa nezinye flavonoid ikhipha ezihlobene. Kukhona ingxenye enkulu yomsebenzi ubufakazi ucwaningo ukuthi luye lwabonisa apigenin has omkhulu engaba ezakhelwe izifo eziningi

umsebenzi:

-Inhibit ukukhula zamangqamuzana omdlavuza.

-Lower blood pressure

-Protects yisimiso senhliziyo nemithambo yegazi

ubuthongo -help, imizwa ezolile, ukuqeda ukucasuka

ukuvuvukala -Resist

kwamathambo -Prevent

umphumela -Diuretic.

-Inhibit platelet wokuhlanganisa.

Isicelo:

-Medicine field, Health care field