Apigenin 98%

Apigenin, as a known bioflavonoid, has been shown to exhibit various biological activities, including antioxidant, anti-inflammatory, antitumor, ant-genotoxic, anti-allergic, neuroprotective, cardioprotective, and antimicrobial.However, One of the most frequent sources of apigenin is celery (Apium graveolens), a marsh plant in the family of Apiaceae that has been cultivated as a vegetable since antiquity. Apigenin is the most extracted nutrient in celery, containing 108 mg apigenin per kg.Apigenin is one of the common dietary flavonoids, which is abundantly found in many fruits, vegetables, and medicinal herbs. It serves various physiological functions, such as antioxidant, potent anti-inflammatory, antiviral activities, antibacterial and blood pressure reduction.

Product Name: caleen celery saaro Apigenin 98%

Name Laatiin: Apium graveolens L.

CAS No: 520-36-5

Plant Part Isticmaalay: Leaf

Walaxda: Apigenin

Isku dayo: Apigenin 98,0% by HPLC

Color: Brown budo jaalaha ah oo ur leh dabeecad iyo dhadhan

Status siibtey: siibtey Free

Xirxirida: in 25kgs fuusto fiber

Kaydinta: Weelka ku hay furin qabow meel, qallalan, ka iftiin xoog leh ku hayso iska

Shelf Life: 24 bilood laga bilaabo taariikhda of-soo-saarka

Anti-buro saamayn

Apigenin kaalin muhiim ah ee ka hortagga kansarka by jiraan apoptosis in khadadka unugyada kala duwan.

kansarka ugxansiduhu:

Qaar ka mid ah cilmi baaris ayaa lagu ogaaday in apigenin la xakameeyo laga yaabaa in koritaanka, badashada, iyo kala iibsiga ee ca-ov3 (unugyada kansarka ugxansiduhu aadanaha); waxaa xaadiriyaan apoptosis ee ca-ov3 iyada oo xajiya Stasis unugyada kansarka ee G2 / M wajiga. Saamaynta la xiriira waqtiga iyo qiyaas.

kansarka ganaca:

Apigenin hor joogsada kartaa kororka ee unugyada kansarka ganaca. Apigenin starves burada by yaraynta isha of glucose, taas oo ah cuntada on kaas oo unugyada kansarka ku nool. Ka sokow, Apigenin hagaajin kartaa waxtarka gemcitabine chemotherapy daroogada ah.

Chemo-wacyigelin

Waxa la ogaaday in apigenin in content low lahaa saamayn cytotoxic hoose iyo ka keenin laga yaabaa leukemia aadanaha myeloid ba'an (HL-60) unugyada in apoptosis wax ku ool ah. Si kastaba ha ahaatee, apigenin kobcin kara saamaynta inhibitory of cisplatin (DDP) ku HL-60 badashada cell halka uruureen kala duwan ee DDP isku. Sidaas Apigenin laga yaabaa in ay saamayn chemotherapy-wacyigelin on HL-60; uruureen Low of apigenin kaloo yarayn karaan caabiga ee HL-60 unugyada in apoptosis chemotherapy-laaluusheen, oo la xiriirta in ay u-sharciyeynta hoos of NF-κB iyo BCL-2. (NF-KB waa nooc ka mid ah oo adag protein oo koontaroosha qoraal DNA, wax soo saarka ee cytokines iyo badbaadada cell, BCL2 waxaa encoded ee jirka iyaga oo maraya hiddo BCL2 ah, waa xubin ka asalka ah ee BCL2 borotiinada sharciyeed qoyska in nidaaminaya kartaa dhimashada unugyada)

ilaalinta Liver

Apigenin yarayn karaa dhaawac beerka ku laaluusheen by ischemia-reperfusion dhex antagonizing peroxidation la egyahay iyo faganaya xagjirka lacag la'aan.

Apigenin yarayn karaa dhaawac beerka ee uu sababo yaqaanaa murqo-ay sabab u tahay antioxidant awood iyo hawlaha anti-bararka.

tijaabo pharmacological waxay caddaysteen in apigenin saamayn muuqata ilaaliya on dhaawac beerka / hepatocyte khamri-laaluusheen, oo ay qaab hoose la xiriira Iscelin ah ee ra'yi dhiibashada CYP2E1 beerka / hepatocyte ah.

looga hortago osteoporosis

Apigenin hakiyo osteoblastogenesis, osteoclastogenesis, iyo sidoo kale ka hortagtaa lafo beesho.

Apigenin ilaaliya unugyada lafta by yaraynta khasaaraha lafaha ee jirka.

Baadhitaanada qaarkood ayaa la xidhiidha ka-MC3T3 E1, line osteoblast cell maamaan ah oo ka soo jeeda musculus Mus (mouse) calvaria, ogaaday in apigenin joogsada kartaa TNF-α, dartid-γ, ka dibna laaluusheen dheecaan dhowr cytokines in la abaabulo samaynta osteoclast.

Apigenin kaloo ku kaladuwan yihiin unugyada maamaan adipose 3T3-L1 galay adipocytes si xoog leh, oo sidaas daraaddeed anada adipocyte Iscelin kala-laaluusheen IL-6, MCP-1, wax soo saarka midiidinka kaladuwan lectin ah.

Apigenin hakiyo kaladuwan ee osteoclasts ka khadadka unugyada RAW264.7 ka dibna uu hakiyo formation of osteoclasts multinucleated. Waxa kale oo ay u abaari karaa apoptosis osteoclast oo la xakameeyo resorption lafaha.

Anti-bararka iyo anti-oxidant waxqabad

Apigenin joojinaya geedi socodka bararka, waxay kordhisaa heerka IL-10 iyo normalizes soo koobin murqo

Apigenin hakiyo cytokines pro-bararka iyo xaadiriyaan goobaha wax soo saarka cytokine anti-bararka.

suugaanta Qaar ka mid ah soo jeedisay in apigenin yarayn barar unugyada laaluusheen by murqo in unugyada by modulating calamado kala duwan oxidative stress, interleukins, qalimaan enzyme dhiig, iyo hadal of dhowr falgalka kale ee la xiriira.

Regulation ah hormoonada

Apigenin nidaaminaya kartaa sonkorta dhiigga, daweeyo la'aan thyroid iyo xakameeyo peroxidation.It la egyahay la ogaaday in apigenin kordhin karaan heerarka insulin iyo tyroksiini in xayawaanka diabetic, iyo hoos u fiirsashada of sonkorta dhiigga iyo waxqabadka of glucose-6-phosphorylase (G- 6-Pase).

Apigenin beddeli saamaynta kordhay kolestaroolka serum, kor u peroxidation la egyahay beerka (Lpo) iyo hawlaha antioksidanter hoos u sida catalase (CAT) iyo dismutase superoxide (caws) ee xoolaha alloxan-laaluusheen.

In xoolaha la sonkorta dhiigga caadiga ah, apigenin kaloo yarayn karaan kolestaroolka serum iyo peroxidation la egyahay beerka, iyo in la kordhiyo waxqabadka ee antioksidanter unugyada.

guryaha pharmacological of apigenin

Apigenin ayaa ku lifaaqan tahay muhiimadda ugu weyn ee sannadihii la soo dhaafay, sida horumariyaha ah ee caafimaadka faa'iido on account of ay sumoobo hoose kala go'lahayn iyo saamaynta caafimaad ee ay si joogta ah oo ay kasoo horjeeddo unugyada kansarka, iyadoo flavonoids kale qaab ahaan la xiriira marka la barbar dhigo. Waxaa bulk ah caddaynta cilmi baarista ayaa lagu muujiyey apigenin leedahay awood-daweynta weyn u cuduro badan oo

function:

-Inhibit koritaanka unugyada kansarka.

cadaadiska dhiigga -Lower

-Protects nidaamka wadnaha

hurdo -Help, dareemayaasha deji, la baabi'iyo caro

caabuq -Resist

osteoporosis -Prevent

saamayn -Diuretic.

xulkii dhiig xinjirowga -Inhibit.

Codsiga:

-Medicine field, Health care field