Apigenin 98%

Apigenin, as a known bioflavonoid, has been shown to exhibit various biological activities, including antioxidant, anti-inflammatory, antitumor, ant-genotoxic, anti-allergic, neuroprotective, cardioprotective, and antimicrobial.However, One of the most frequent sources of apigenin is celery (Apium graveolens), a marsh plant in the family of Apiaceae that has been cultivated as a vegetable since antiquity. Apigenin is the most extracted nutrient in celery, containing 108 mg apigenin per kg.Apigenin is one of the common dietary flavonoids, which is abundantly found in many fruits, vegetables, and medicinal herbs. It serves various physiological functions, such as antioxidant, potent anti-inflammatory, antiviral activities, antibacterial and blood pressure reduction.

Product Name: Celery shizha kusvina Apigenin 98%

Latin Name: Apium graveolens L.

CAS No: 520-36-5

Plant Part Used: Leaf

Chirungiso: Apigenin

Munhu akaidza: Apigenin 98,0% kubudikidza HPLC

Color: Brown kuti yero upfu pamwe mamirire kwakanaka uye kuravira

GMO Status: GMO Free

Apex muna 25kgs faibha ngoma

Storage: Rambai mudziyo unopened kuchitonhora, panzvimbo yakaoma, Rambai kure chiedza simba

Pasherufu Life: 24 mwedzi kubva musi okuwana

Anti-mota kushanda

Apigenin anobatsira inokosha basa mukudzivirira kenza kuburikidza kufurira apoptosis mu siyana muchitokisi mitsetse.

Ovarian kenza:

Tsvakurudzo kwakawanikwa kuti apigenin aigona tunodzivisa kukura, kuwanda, uye kuchinjwa CA-ov3 (dzevanhu ovarian kenza sero); izvozvo induces apoptosis pamusoro CA-ov3 kuburikidza nokuchengeta kenza masero stasis mu G2 / M danho. Kuvhiringidzwa wakabatana nguva uye dose.

Pancreatic kenza:

Apigenin anogona tunodzivisa kuwandisa pancreatic kenza. Apigenin starves bundu Akaroromesawo kunobva shuga, unova chikafu apo nekenza masero kurarama. Kunze, Apigenin anogona anyatsobudirira ari mishonga drug- gemcitabine.

Chemo-sensitization

It Vakawana kuti apigenin mu pasi kugutsikana aiva pasi cytotoxic kushanda uye vaisagona kunyengedza munhu chakasimba myeloid neleukemia (hl-60) masero kuti apoptosis zvinobudirira. Zvisinei, apigenin anogona kuwedzera inhibitory mugumisiro cisplatin (DDP) pamusoro hl-60 foni kuwanda apo tichibatanidza ne zvakasiyana kuwanda DDP. Saka Apigenin vangava mishonga-sensitization kubatsira hl-60; Low kuwanda apigenin vanogona kuderedza nemishonga yose hl-60 masero kuti mishonga Kutemeswa apoptosis, izvo zvinogona chokuita pasi-mutemo NF-κB uye BCL-2. (NF-KB ari mapuroteni kunzwisisa imwe mhando kuti anodzora DNA transcription, kugadzirwa cytokines uye sero kurarama; BCL2 iri encoded mumuviri kubudikidza BCL2 Gene, ndiwo nhengo BCL2 pamutemo mapuroteni mhuri yepakutanga anogona kudzora sero rufu)

chiropa kudzivirirwa

Apigenin anogona kuderedza kukuvadzwa chiropa kunokonzerwa ischemia-reperfusion kuburikidza antagonizing lipid peroxidation uye nokudya zvokupara vakasununguka radicals.

Apigenin kunogona kuderedza kukuvara chiropa kunokonzerwa oxidative kunetseka nokuda kwayo simba antioxidant uye Anti-anogumbura mabasa.

Pharmacological kuedza akaratidza kuti apigenin ane pachena unodzivirira kubatsira doro Kutemeswa chiropa / hepatocyte kukuvara, uye mashandiro ayo chikuru yakabatana chinovhiringidza pamusoro CYP2E1 mashoko ari chiropa / hepatocyte.

kudzivirira osteoporosis

Apigenin kuchititadzisa osteoblastogenesis, osteoclastogenesis, uye chinonditadzisa mapfupa kurasikirwa.

Apigenin anodzivirira pfupa rinenge nokuderedza mapfupa kurasikirwa mumuviri.

Vamwe zvidzidzo chokuita MC3T3-E1, imwe osteoblast aizotangira sero mutsetse zvinobva Mus musculus (mbeva) calvaria, vakawana kuti apigenin anogona tunodzivisa TNF-α, IFN-γ, uye ipapo akanyengera secretion pamusoro cytokines akawanda kuti pave osteoclast inotungamirwa.

Apigenin zvakare hwakaipa ari Kusiyanisa pamusoro 3T3-L1 adipose aizotangira masero kupinda adipocytes zvakasimba, saka zvichivhiringidza ari Kusiyanisa mushandi chinovhiringidza adipocyte Kusiyanisa Kutemeswa IL-6, MCP-1, lectin chigadzirwa.

Apigenin kuchititadzisa ari Kusiyanisa ose osteoclasts kubva RAW264.7 muchitokisi mitsetse uye ipapo kuchititadzisa paumbwe multinucleated osteoclasts. Rinogonawo kunyengedza osteoclast apoptosis uye tunodzivisa mapfupa resorption.

Anti-anogumbura uye Anti-oxidant basa

Apigenin anodzora chokutsva kwacho, inowedzera IL-10 nhanho uye normalizes kuti oxidative kunetseka parameters

Apigenin kuchititadzisa aifarira-anogumbura cytokines uye induces Anti-anogumbura cytokine kugadzirwa.

Vamwe mabhuku kunoratidza kuti apigenin Kunoderedza zvinyama kuzvimba kunokonzerwa oxidative kushushikana mune munyama nokuda modulating siyana oxidative kunetseka zvezvinangwa, mainterleukin, ropa enzayemu zvezvinangwa, uye kutaura nevamwe chokuita makemikari akawanda.

Regulation nezvokushanda kwemakemikari anobudiswa

Apigenin anogona chengetedza ropa shuga, kurapa thyroid insufficiency uye kudzora lipid peroxidation.It kuwanikwa kuti apigenin aigona kuwedzera kwevari insulin uye thyroxine kwemhuka chirwere cheshuga, uye kuderera wevasungwa yomuropa uye nebasa shuga-6-phosphorylase (G- 6-Pase).

Apigenin kunoshandurwa migumisiro yakawedzera serum remafuta akawandisa, vakawedzera chiropa lipid peroxidation (LPO) uye ungaderedza mabasa antioxidants akadai catalase (CAT) uye superoxide dismutase (pevhu) kwemhuka alloxan Kutemeswa.

In nemhuka dzose ropa shuga, apigenin anogona kuderedza serum remafuta akawandisa uye chiropa lipid peroxidation, uye kuwedzera basa antioxidants mumasero.

Pharmacological ehupfumi kuti apigenin

Apigenin rave kuda zvikuru kukosha mumakore achangodarika, somunhu kunobatsira utano mutsigiri nokuda kwayo ezasi mukati toxicity uye ayo utano migumisiro nokugara maringe masero kenza, zvichienzaniswa nevamwe zvayakaita ukama flavonoids. Pane unorema tsvakurudzo uchapupu akaratidza apigenin rine kuchirapa zvinogona zvirwere zvakawanda

basa:

-Inhibit kukura masero kenza.

-Lower BP

-Protects kumwoyo

-Help hope, kudzikama tsinga, kubvisa kushatirwa

-Resist kuzvimba

-Prevent osteoporosis

-Diuretic kushanda.

-Inhibit platelet aggregation.

Application:

-Medicine field, Health care field