Kashi 98%

Apigenin, as a known bioflavonoid, has been shown to exhibit various biological activities, including antioxidant, anti-inflammatory, antitumor, ant-genotoxic, anti-allergic, neuroprotective, cardioprotective, and antimicrobial.However, One of the most frequent sources of apigenin is celery (Apium graveolens), a marsh plant in the family of Apiaceae that has been cultivated as a vegetable since antiquity. Apigenin is the most extracted nutrient in celery, containing 108 mg apigenin per kg.Apigenin is one of the common dietary flavonoids, which is abundantly found in many fruits, vegetables, and medicinal herbs. It serves various physiological functions, such as antioxidant, potent anti-inflammatory, antiviral activities, antibacterial and blood pressure reduction.

Samfurin Name: Seleri leaf cire apigenin 98%

Latin Name: Apium graveolens L.

CAS Babu: 520-36-5

Shuka Part Used: Leaf

Sashi: apigenin

Kima: apigenin 98,0% by HPLC

Launi: Brown zuwa rawaya foda da halayyar wari da kuma dandano

GMO Status: GMO Free

Shiryawa: a 25kgs fiber ganguna

Storage: Ka ganga unopened a sanyi, bushe wuri, Ku tafi daga karfi haske

Shiryayye Life: 24 months daga ranar samarwa

Anti-ƙari sakamako

Apigenin taka wani muhimmanci rawa a daji da rigakafin da inducing apoptosis a daban-daban cell Lines.

Ovarian ciwon daji:

Wasu bincike an gano cewa, apigenin iya hana ci gaban, yaduwa, da kuma canja wurin da ca-ov3 (mutum ovarian ciwon daji cell); shi yanã apoptosis na ca-ov3 ta hanyar kiyaye ciwon daji Kwayoyin stasis a G2 / M lokaci. A sakamako ne alaka zuwa lokaci, kuma kashi.

Pancreatic ciwon daji:

Apigenin iya hana yaduwa na pancreatic ciwon daji Kwayoyin. Apigenin starves da ƙari ta rage tushen glucose, wanda shine abinci a kan wanda cancers Kwayoyin rayuwa. Bayan haka, apigenin iya inganta tasiri na jiyyar cutar sankara drug- gemcitabine.

Chemo-sensitization

An gano cewa apigenin a low abun ciki da wani low cytotoxic sakamako kuma ba zai iya sa mutum m myeloid cutar sankarar bargo (hl-60) Kwayoyin to apoptosis yadda ya kamata. Duk da haka, apigenin iya bunkasa hana ruwa guda sakamako na cisplatin (DDP) a kan hl-60 cell yaduwa yayin hada da daban-daban yawa na DDP. Saboda haka apigenin iya samun jiyyar cutar sankara-wayar da sakamako a kan hl-60. Low yawa na apigenin kuma iya rage juriya na hl-60 Kwayoyin to jiyyar cutar sankara-jawo apoptosis, wanda za a iya alaka da saukar-tsari daga NF-κB da BCL-2. (NF-KB ne wani nau'i ne na gina jiki da hadaddun da iko DNA kwafi, da samar da cytokines da cell rayuwa; BCL2 aka shigar wanda ke aiki a cikin jiki ta hanyar da BCL2 gene, shi ne asalin memba na BCL2 kullum sunadaran iyali cewa iya tsara wayar mutuwa)

hanta kariya

Apigenin iya rage hanta lahani jawo by ischemia-reperfusion ta hanyar antagonizing sia peroxidation da scavenging free radicals.

Apigenin iya rage hanta lahani lalacewa ta hanyar oxidative danniya saboda ta m antioxidant da anti-mai kumburi ayyukan.

Pharmacological gwaje-gwajen sun tabbatar da cewa apigenin yana da wani fili m sakamako a kan barasa-jawo hanta / hepatocyte rauni, kuma ta farko inji aka alaka da hanawa na CYP2E1 magana a cikin hanta / hepatocyte.

hana osteoporosis

Apigenin damuarn osteoblastogenesis, osteoclastogenesis, da kuma hana kashi hasãra.

Apigenin kare kashi nama ta rage kashi hasãra a cikin jiki.

Wasu nazarin alaka da MC3T3-E1, wani osteoblast precursor cell line samu daga Mus musculus (linzamin kwamfuta) calvaria, ya gano cewa, apigenin iya hana TNF-α, IFN-γ, sa'an nan jawo mugunya da dama cytokines da inganta osteoclast samuwar.

Apigenin kuma hana ta bambantawa na 3T3-L1 adipose precursor Kwayoyin a cikin adipocytes karfi, saboda haka inhibiting da bambantawa bawa hanawa adipocyte bambantawa-jawo Il-6, MCP-1, lectin samfurin.

Apigenin damuarn da bambantawa na osteoclasts daga RAW264.7 cell Lines sa'an nan damuarn samuwar multinucleated osteoclasts. Yana kuma iya sa osteoclast apoptosis da kuma hana kashi resorption.

Anti-mai kumburi da anti-oxidant aiki

Apigenin riƙe kumburi tsari, qara Il-10 matakan da daidai a cikin oxidative danniya sigogi

Apigenin damuarn pro-kumburi cytokines kuma yanã da anti-mai kumburi cytokine samar.

Wasu adabi da shawara cewa apigenin alleviates nama kumburi jawo by oxidative danniya a kyallen takarda ta modulating daban-daban oxidative danniya alamomi, interleukins, jini enzyme alamomi, da kuma aikewa da dama sauran related enzymes.

Regulation na endocrine

Apigenin iya gwada jini sugar, bi da thyroid insufficiency da kuma iko da sia peroxidation.It aka samu cewa apigenin iya kara matakan da insulin da thyroxine a m dabbobi, da kuma rage taro na jini sukari da kuma na ayyuka na glucose-6-phosphorylase (G- 6-Pase).

Apigenin juyawa da sakamakon ƙãra magani cholesterol, ta ƙara hanta sia peroxidation (LPO) da kuma rage ayyukan antioxidants kamar catalase (CAT) da kuma superoxide dismutase (sod) a alloxan-jawo dabbobi.

A dabbobi da na yau da kullum jini sugar, apigenin kuma iya rage magani cholesterol da hanta sia peroxidation, da kuma kara da ayyukan antioxidants a Kwayoyin.

Pharmacological Properties na apigenin

Apigenin da aka dora muhimmanci a cikin 'yan shekaru, kamar yadda wani m kiwon lafiya kiran kasuwa sabõda da ƙananan muhimmi yawan guba da kuma ta kiwon lafiya effects a yau da kullum a kan ciwon daji Kwayoyin, idan aka kwatanta da sauran fasali mai alaka flavonoids. Akwai girma na bincike da shaida cewa ya nuna apigenin yana mai warkewa yiwuwar yawa cututtuka

aiki:

-Inhibit ci gaban da ciwon daji Kwayoyin.

-Lower jini

-Protects zuciya da jijiyoyin jini tsarin

-Ka taimake barci, a kwantar da hankula jijiyoyi, kawar da irritability

-Resist kumburi

-Prevent osteoporosis

-Diuretic sakamako.

-Inhibit platelet tari.

Application:

-Medicine field, Health care field