Ikhompawundi yendalo efumaneka kwi-strawberry kunye nezinye iziqhamo kunye nemifuno inokunceda ukuthintela isifo se-Alzheimer kunye nezinye izifo ezinxulumene nobudala, uphando olutsha lucebisa.
Abaphandi abavela eSalk Institute for Biological Study eLa Jolla, CA, kunye noogxa bafumanise ukuba ukunyanga iimodeli zeempuku zokuguga nge-fisetin kukhokelele ekunciphiseni ukwehla kwengqondo kunye nokudumba kwengqondo.
Umbhali ophakamileyo wokufunda uPamela Maher, weLebhu yeLebhu yeNzululwazi yeNzululwazi eSalk, kunye noogxa bakhe kutshanje banike ingxelo ngeziphumo zabo kwiJenali zeGerontology Series A.
IFisetin yiflavanol ekhoyo kwiintlobo ngeentlobo zeziqhamo nemifuno, kubandakanya amaqunube, iipersimmon, iiapile, iidiliya, itswele, kunye neekomkomere.
Ayisiyiyo kuphela i-fisetin esebenza njengearhente yokufaka imibala kwiziqhamo kunye nemifuno, kodwa uphononongo luye lwabonisa ukuba ikhompawundi ineempawu zokulwa ne-antioxidant, okuthetha ukuba inokunceda ukunciphisa umda wokonakaliswa kweseli okubangelwa ziiradicals zasimahla. I-Fisetin ikwabonakalisiwe ukunciphisa ukudumba.
Kule minyaka ili-10 idlulileyo, uMaher kunye noogxa bakhe baqhube izifundo ezininzi ezibonisa ukuba iipropathi zokulwa ne-antioxidant kunye ne-anti-inflammatory ye-fisetin inokunceda ukukhusela iiseli zobuchopho ngokuchasene nokuguga.
Olunye uphononongo olunje, olwapapashwa ngo-2014, lwafumanisa ukuba i-fisetin inciphise ukulahleka kwememori kwiimodeli zesifo se-Alzheimer's. Nangona kunjalo, olo phononongo lujolise kwiziphumo ze-fisetin kwiimpuku ezinesifo se-Alzheimer's, apho abaphandi baqaphela kuphela ii-akhawunti ukuya kuthi ga kwipesenti ezi-3 zamatyala onke e-Alzheimer's.
Kwisifundo esitsha, uMaher kunye neqela bafuna ukufumanisa ukuba ingaba i-fisetin inokuba nezibonelelo zesifo i-Alzheimer's sporadic, yeyona ndlela ixhaphakileyo evela kubudala.
Ukufikelela kwiziphumo zabo, abaphandi bavavanya i-fisetin kwiimpuku ezazenziwe ngobunjineli kwimfuza ngaphambi kwexesha, okukhokelela kwimodeli yegundane yesifo i-Alzheimer's sporadic.
Xa iimpuku eziguga ngaphambi kwexesha zazineenyanga ezintathu ubudala, zahlulahlulwa zangamaqela amabini. Elinye iqela londliwe idosi ye-fisetin ngokutya kwabo yonke imihla kangangeenyanga ezi-7, de bafikelela kubudala beenyanga ezili-10. Elinye iqela alifumananga khompawundi.
Iqela licacisa ukuba kwiinyanga ezili-10 ubudala, imeko yomzimba kunye nengqondo yeempuku zazilingana neempuku ezineminyaka emi-2 ubudala.
Zonke iintonga beziphantsi kovavanyo lokuqonda kunye nokuziphatha kulo lonke uphononongo, kwaye abaphandi baphinde bavavanya iimpuku kumanqanaba okumakisha ahambelana noxinzelelo kunye nokudumba.
Abaphandi bafumanise ukuba iimpuku ezineenyanga ezili-10 ezingakhange zifumane fisetin zibonise ukonyuka kwamakishi ahambelana noxinzelelo kunye nokudumba, kwaye benze kakubi kakhulu kwiimvavanyo zokuqonda kuneempuku ezazinyangwa nge-fisetin.
Ebuchotsheni beempuku ezinganyangekiyo, abaphandi bafumanise ukuba zimbini iintlobo zee-neurons ezihlala zichasene nokuvuvukala -i-astrocyte kunye ne-microglia-eneneni zikhuthaza ukudumba. Nangona kunjalo, oku bekungekho kwimeko yeempuku zeenyanga ezili-10 eziphathwe nge-fisetin.
Ngapha koko, abaphandi bafumanise ukuba indlela yokuziphatha kunye nokusebenza kwengqondo kweempuku eziphathwayo zithelekiswa nezo zeempuku ezinganyangekiyo ezinenyanga ezintathu ubudala.
Abaphandi bakholelwa ukuba iziphumo zabo zibonisa ukuba i-fisetin inokukhokelela kwisicwangciso esitsha sokuthintela i-Alzheimer's, kunye nezinye izifo ezinxulumene nobudala.
"Ngokusekwe kwimisebenzi yethu eqhubekayo, sicinga ukuba i-fisetin ingaluncedo ekuthinteleni izifo ezininzi ezinxulumene nobudala be-neurodegenerative, hayi i-Alzheimer's kuphela, kwaye singathanda ukukhuthaza ukuba kufundwe nzulu ngayo," utshilo uMaher.
Nangona kunjalo, abaphandi baqaphela ukuba ulingo lweklinikhi lomntu luyafuneka ukuqinisekisa iziphumo zabo. Banethemba lokudibana nabanye abaphandi ukuhlangabezana nale mfuno.
“Iimpuku ayingobantu, kunjalo. Kodwa kukho ukufana okwaneleyo esicinga ukuba i-fisetin ifuna ukuba sijongwe, kungekuphela nje ukunyanga i-AD [isifo sika-Alzheimer] kodwa nokunciphisa ezinye zezinto ezinxulumene nokwaluphala, ngokubanzi. ”
Ixesha Post: Apr-18-2020