Sialic Acid Powder

Is aigéad sialic (SA), ar a dtugtar heolaíoch mar "aigéad N-acetylneuraminic," carbaihiodráit a tharlaíonn go nádúrtha. Bhí sé scoite ó dhúchas an mucin gland submandibular, mar sin, an t-ainm. Is aigéad sialic de ghnáth i láthair i bhfoirm olagaishiúicrídí, glycolipids nó glycoproteins. I gcorp an duine, tá an inchinn an t-ábhar is airde aigéad sialic. Is é an t-ábhar aigéad sialic san ábhar liath 15 uair sin de na orgáin inmheánacha ar nós ae agus scamhóg. Is é an fhoinse bia is mó d'aigéad sialic bainne cíche, atá le fáil freisin i bainne, uibheacha agus cáis.

I leigheas, glycolipids ina bhfuil aigéad sialic Tugtar gangliosides, a bhfuil ról an-tábhachtach i dtáirgeadh agus i bhforbairt an inchinn agus córas néaróg. Ag an am céanna, tá staidéir ar ainmhithe léirithe go bhfuil an laghdú ar leibhéil ganglioside a bhaineann le míchothú luath agus cumas foghlama laghdaithe, agus is féidir fhorlíonadh le haigéad sialic feabhas a chur ar iompar foghlama ainmhithe. Is féidir go mbeidh dóthain soláthair aigéad sialic a bheith tábhachtach maidir le forbairt gnáth fheidhm na hinchinne i leanaí a bhfuil meáchan breithe íseal. Tar éis an leanbh a rugadh, tá an t-aigéad sialic sa bhainne cíche riachtanach lena chinntiú a bhforbairt gnáth. Imscrúduithe Tá sé léirithe go bhfuil leibhéil aigéad sialic i máithreacha tar éis meath luí seoil le himeacht ama. Dá bhrí sin, Is féidir le iontógáil leanúnach méid leordhóthanach de aigéad sialic le linn toirchis agus i ndiaidh toirchis cabhrú le leibhéil aigéad sialic i gcorp a choimeád ar bun. Thairis sin, tá an t-ábhar aigéad sialic correlated go mór le hábhar DHA, le tuiscint go bhfuil sé an-dócha a bheith bainteach le struchtúr na hinchinne agus forbairt fheidhm na hinchinne i naíonáin, féadfaidh an dá cheann acu chun leasa do fhorbairt inchinne luath.

Staidéar a thaispeáint go bhfuil an tréimhse órga na forbartha inchinn an duine idir aois 2 agus 2 bhliain d'aois. Is é an chéim ar feadh tréimhse ríthábhachtach maidir le coigeartú cille inchinn uimhir, méadú ar líon, foirfeacht feidhme, agus foirmiú líonra neural. Mar sin, beidh máithreacha cliste íoc go nádúrtha aird ar an iontógáil méid leordhóthanach de aigéad sialic le linn toirchis. I ndiaidh an leanbh a rugadh, tá bainne cíche ar bhealach éifeachtach aigéad sialic a chur leis an leanbh, mar gheall ar thart ar 0.3-1.5 mg d'aigéad sialic aghaidh millilítear bainne cíche. Go deimhin, gach mamaigh, lena n-áirítear daoine, atá in ann a synthesize aigéad sialic ón ae féin. Mar sin féin, nach bhfuil an fhorbairt ae na leanaí nuabheirthe fós aibí, agus an gá atá le fás agus forbairt an inchinn tapa a theorannú i shintéis na aigéad sialic, go háirithe do naíonáin roimh am. Dá bhrí sin, tá aigéad sialic i mbainne cíche riachtanach a chinntiú fás gnáth agus forbairt an linbh.
Taighdeoirí na hAstráile a fuarthas amach go bhfuil naíonáin chíche-chothaithe tiúchan níos airde de aigéad sialic sa cortex tosaigh ná mar naíonáin foirmle-chothaithe. D'fhéadfadh sé seo a chur chun cinn foirmiú na synapses, cuidiú leis an leanbh a chuimhne a bheith ina mbonn struchtúrtha níos cobhsaí, agus ar fhorbairt an néarchóras a neartú.

What is Sialic acid

sialic Aigéad is a group of derivatives of neuraminic acid (N- or O-substituted derivatives neuraminic acid). Usually in the form of oligosaccharides, glycolipids or glycoproteins.

Sialic Acid is also the name for this group’s most common member – N-acetylneuraminic acid (Neu5Ac or NANA).

Sialic acid family

It has been known for nearly 50 members, all derivatives of the negatively charged 9-carbon sugar neuraminic acid.

N-acetylneuraminic acid (Neu5Ac), N-glycolylneuraminic

acid (Neu5Gc) and deaminoneuraminic acid (KDN) are its core monomer.

N-acetylneuraminic acid is the only kind of Sialic Acid in our body.

Sialic Acid and Bird’s nest

Because Sialic acid is rich in bird’s nest, it is also called bird’s nest acid, which is an essential indicator of bird’s nest grading.

Sialic Acid is the main nutrition ingredients in Bird’s nest, around 3%-15% by weight.

Among all the known foods, Bird’s nest contains the highest content of Sialid acid, around 50 times higher than other foods.

1g Bird’s nest equals 40 eggs if we get the same quantity of Sialic Acid.

Sialic Acid food sources

Generally, plants contain no Sialic acid. The leading supply of Sialic acid is human milk, meat, egg, and cheese.

Contents of total Sialic acid in conventional foods (µg/g or µg/ml).

We can see that the Sialic acid in Human milk is high, which is the key ingredient for a baby’s brain development.

But Sialic Acid content is different in different Periods Human milk

Breast milk colostrum  1300 +/- 322 mg/l

10 days later    983 +/- 455 mg/l

Preterm infant milk powder    197 +/- 31 mg/l

Adapted milk formulas  190 +/- 31 mg/l

Partially adapted milk formulas 100 +/- 33 mg/l

Follow-up milk formulas 100 +/- 33 mg/l

Soy-based milk formulas 34 +/- 9 mg/l

Compared with Breast milk, Infant milk powder contains around 20% Sialic acid from Human milk, while the baby can only get 25% Sialic acid from Breast milk.

For a Preterm baby, Sialic acid is more essential than a healthy baby in Brain development.

Sialic Acid Study on Milk powder

“The results indicated that brain sialic acid content plays an important role in determining behavior. Another group observed improved learning with free sialic acid treatment in rodents.”

CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition, and Natural

Resources 2006 1, No. 018， Is sialic acid in milk food for the brain?， Bing Wang

“The Conclusion is Higher brain ganglioside and glycoprotein sialic acid concentrations in infants fed human milk suggests increased synaptogenesis and differences in neurodevelopment.”

Am J Clin Nutr 2003;78:1024–9. Printed in the USA. © 2003 American Society for Clinical Nutrition，Brain ganglioside, and glycoprotein sialic acid in breastfed compared with formula-fed infants， Bing Wang

“Neural cell membranes contain 20 times more sialic acid than other types of membranes, indicating that sialic acid has a clear role in neural structure.”

The European Journal of Clinical Nutrition, (2003) 57, 1351–1369, The role and potential of sialic acid in human nutrition, Bing Wang

N-Acetylneuraminic acid Application

Milk Powder

Currently, More and more Breastfeeding mothers’ milk powder, Babies’ Milk powder, and Nutritional supplements contain Sialic Acid on the Market.

For Breastfeeding Mothers

For Baby Milk powder 0-12 months

For Healthcare product

For Beverage

Since Sialic acid has a good water-soluble ability, many companies are trying to development Sialic acid beverages for Brain health or add into milk products.

N-Acetylneuraminic acid Safety

N-Acetylneuraminic acid is very safe. Currently, no negative news reported on Sialic acid.

The USA, China, and EU governments approve Sialic acid to be used in Food and Health care products.

USA

In 2015, N-Acetyl-D-neuraminic acid (Sialic acid) was determined Generally Recognized as Safe (GRAS)

China

In 2017, China Government approved N-Acetylneuraminic acid as a New Resource Food Ingredient.

EU

Safety of synthetic N-acetyl-d-neuraminic acid as a novel food under Regulation (EC) No 258/97

On 16 October 2015, orphan designation (EU/3/12/972) was granted by the European Commission to Ultragenyx UK Limited, United Kingdom, for sialic acid (also known as aceneuramic acid) for treatment of GNE myopathy.

Scientific Opinion on the substantiation of health claims related to sialic acid and learning and memory (ID 1594) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

Dosage

CFDA suggest 500mg/day

Novel food suggests 55mg/day for Infant and 220mg/day for Young and middle-aged women

N-acetylneuraminic acid Function

Memory and Intelligence improvement

By interacting with brain cell membranes and synapses, Sialic acid increases the response rate of synapses in the brain’s nerve cells, thereby promoting the development of memory and intelligence.

New Zealand scientists have done a series of experiments to confirm the critical role of bird’s nest acid in children’s intellectual development. Finally, the researchers concluded that supplementing bird’s nest acid in infants could increase the concentration of bird’s nest acid in the brain, thereby improving the brain’s ability to learn.

Improve intestinal absorption capacity

According to the simple physical phenomenon of the opposite sex, the positively charged minerals and some vitamins that enter the intestine are easily combined with the strong negatively charged bird’s nest acid, so the intestinal absorption of vitamins and minerals. The ability has been enhanced from it.

Promote intestinal antibacterial detoxification

Sialic Acid on the cell membrane protein plays a crucial role in improving cell recognition ability, detoxification of cholera toxin, prevention of pathological Escherichia coli infection, and regulation of blood protein half-life.

Longevity

Sialic acid has a protective and stabilizing effect on cells, and the lack of sialic acid can lead to a decrease in blood cell life and a decrease in glycoprotein metabolism.

Develop new medicine for Sialic Acid

Scientists try to treat gastrointestinal diseases with sialic acid anti-adhesion drugs. Sialic acid anti-adhesive drugs can treat Helicobacter pylori to treat gastric ulcers and duodenal ulcers.

Sialic acid is a glycoprotein. It determines the mutual recognition and binding of cells and has clinically similar anti-inflammatory effects as aspirin.

Sialic acid is a drug for central or topical neurological diseases and demyelinating diseases; sialic acid is also a cough expectorant.

Sialic acid as a raw material can develop a series of essential sugar drugs, anti-virus, anti-tumor, anti-inflammatory, and treatment of senile dementia have outstanding results.

The production process of Sialic Acid

The starting raw materials are mainly glucose, corn steep liquor,glycerinum, and magnesium sulfate. And we use fermented technology. During this process, we use the way of sterilization to keep the materials clean. Then by hydrolysis, concentration, drying, and smashing. After all the processes, we get the final product. And our QC will use HPLC to test the material quality for every batch before we deliver it to the clients.

Ainm Táirge: aigéad sialic; Aigéad N-Acetylneuraminic

Eile Ainm: 5-Acetamido-3,5-dideoxy-D-glycero-D-galactonulosonic aigéad o-sialic Aigéad aigéad Galactononulosonic Aigéad Lactaminic Aigéad NANA N-Acetylsialic

Origin: éan inite nead
Spec: 20% -98%
Dealramh: púdar fíneáil bán
CAS NÍL .: 131-48-6
MW: 309.27
MF: C11H19NO9

Áit Origin: An tSín

Stóráil: Stóráil in áit fionnuar agus tirim, a choinneáil ar shiúl ó na solas díreach agus teas.
Bailíocht: Dhá bhliain má stóráil i gceart.

FEIDHM:

1. Feidhm Frith-víreas.
2. Feidhm Frith-ailse.
3. Feidhm Frith-athlasadh.
4. fheidhm cosanta i gcoinne infectiong baictéareolaíochta.
5. Rialú cumas chóras imdhíonachta.
6. cumas Srianta aghaidh pigmentation.
7. Signal claochlú i cealla nerve.
8. Ról lárnach i bhforbairt agus i bhfoghlaim inchinne.
9. Mar réamhtheachtaí do mhonarú drugaí cógaisíochta go leor.