Oleanolic Acid Powder

Oleanolic suur wat 'n drie pentasikliese triterpenoids geïsoleerd van Gentianaceae plante van Swertia mileensis die hele gras of privet vrugte, met 'n gratis liggaam en glikosiede in baie plante. Oleanolic suur het 'n wye verskeidenheid in plante, en die gemiddelde inhoud is 0,2% - 2%. Cucurbitaceae hoë inhoud is 1,5% ~ boggelrug onderste 2%, privet vrugte inhoud van 0,6% ~ 0,7% .Oleanolic suur is 'n soort van pentasikliese triterpenoïedsaponien saamgestelde geïsoleerd van die vrugte van die genus Asteraceae, Syzygium sylvestris, of Ligustrum lucidum. Dit is 'n lewersiekte bevorderingsmiddel en klinies gebruik word vir terapeutiese infeksie. Akute geelsug hepatitis het voor die hand liggend uitwerking op die vermindering van glutamaatpyruvaattransaminase en yellowing.Oolic suur is 'n pentasikliese triterpenoids geïsoleerd van die vrugte van swertia chinensis of fructus ligustris van die gentianaceae plant. Oleanolic suur word algemeen gevind in plante, met 'n algemene inhoud van 0,2% ~ 2% [1]. Die inhoud van onderkant van kalbas was 1,5% ~ 2%, en die inhoud van vrugte van fructus ligustris was 0,6% ~ 0,7%. Oleanolic suur is wit acicular kristal (etanol), reukloos en smaakloos. Onstabiele om sure en basisse. Smeltpunt van 308 ~ 310 ℃, [alpha] 20 d + 73,3 ° (c = 0,15, chloroform, onoplosbaar in water, oplosbare in metanol, etanol, ethyl eter, asetoon en chloroform.Oleanolic suur is 'n natuurlik voorkom triterpenoïedsaponien, wyd versprei in kos en medisinale plante, wat verband hou met betulinic suur. Dit kan gevind word in Phytolacca americana (Amerikaanse pokeweed), en Syzygium spp, knoffel, ens Dit is relatief nie-giftige, hepatoprotective, en uitstallings A. procumbens en antivirale eienskappe.
Oleanolic suur was gevind sterk anti-MIV-aktiwiteit uit te stal, is die verwante saamgestelde betulinic suur wat gebruik word om die eerste kommersiële veroudering inhibitor dwelm te skep. Dit is die eerste keer bestudeer en geïsoleerd van verskeie plante, insluitend Rosa woodsii (blare), Prosopis glandulosa (blare en takkies), Phordendron juniperinum (hele plant), Syzygium claviflorum (blare), Hyptis capitata (hele plant), en Ternstromia gymnanthera (lug deel). Ander Syzygium spesies, insluitend Java appel (Syzygium samarangense) en rose appel s bevat dit.

Produk Naam: Oleanolic Suur  98 %

Spesifikasie: 98% deur HPLC

Botaniese Bron: Olea Europea Extract

Chemiese Naam: (3β) -3-Hydroxyolean-12-en-28-OIC suur

CAS No: 508-02-1

Deel gebruik: Leaf

Kleur: Wit poeier met kenmerkende reuk en smaak

GMO Status: GMO Gratis

Verpakking: in 25kgs vesel tromme

Stoor: Hou die houer onoopgemaak in koel, droë plek, weg van 'n sterk lig

Raklewe: 24 maande vanaf die datum van vervaardiging

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

funksie:

1.Oleanolic suur is relatief nie-giftige, A. procumbens, en hepatoprotective, asook uitstal antivirale eienskappe.
2.Oleanolic suur Daar is gevind dat 'n sterk anti-MIV-aktiwiteit uit te stal.
3.Oleanolic suur is 'n groot beskermer van selle teen oksidatiewe en Elektrofiel stres.
4.Oleanolic suur het 'n groot invloed op trating virus hepatitis, akute geelzuchtig hepatitis en chroniese hepatitis.
aansoek:
1. Toegepaste in voedsel veld, kan dit dien as grondstowwe van tee na slym te verminder;
2. Toegepaste in farmaseutiese veld, is dit 'n nuwe anti-kankermiddel met 'n lae giftige;
3. Toegepaste in kosmetiese veld, kan dit die bloedsomloop versterk en te verwyder drank.