Wholesale Oleanolic Acid powder manufacturers and suppliers | Tong Rui Bio-Tech

Oleanolic Acid Powder

Maelezo Mafupi:

asidi oleanolic alionekana kuonyesha nguvu shughuli za kupambana na virusi vya ukimwi, kuhusiana na kiwanja asidi betulinic ilitumika kujenga ya kwanza ya kibiashara kukomaa kiviza madawa ya kulevya. Ni mara ya kwanza alisoma na kutengwa kutoka kwa mimea kadhaa, ikiwa ni pamoja na Rosa woodsii (majani), Prosopis glandulosa (majani na matawi), Phordendron juniperinum (kupanda kwa ujumla), Mizambarau claviflorum (majani), Hyptis capitata (kupanda kwa ujumla), na Ternstromia gymnanthera (angani sehemu). Mizambarau aina nyingine ikiwa ni pamoja na java apple (Mizambarau samarangense) na ilipanda apples vyenye yake.


  • Bei ya FOB: US $0.5 - 2000 / KG
  • Min.Order Wingi: 1 KG
  • Kawaida Uwezo: 10000 KG / kwa Mwezi
  • Bandari: Shanghai / BEIJING
  • Masharti ya malipo: L / C, D / A, D / P, T / T
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  • Bidhaa Detail

    Tags bidhaa

    Asidi oleanolic ambayo ni tatu pentacyclic triterpenoids pekee kutoka mimea Gentianaceae ya Swertia mileensis nzima nyasi au privet matunda, pamoja na mwili bure na glycosides katika mimea mingi. Asidi oleanolic ina mbalimbali katika mimea, na maudhui ya wastani ni 0.2% - 2%. Cucurbitaceae high maudhui ni 1.5% ~ kigongo chini 2%, privet matunda maudhui ya 0.6% ~ 0.7% .Oleanolic asidi ni aina ya pentacyclic triterpenoid kiwanja pekee kutoka matunda ya jenasi Asteraceae, Mizambarau sylvestris, au LIGUSTRUM Lucidum. Ni ugonjwa wa ini itakayosaidia na kiafya kutumika kwa ajili ya maambukizi ya matibabu. Papo hapo manjano hepatitis ina athari za wazi kuhusu kupunguza alanine kisagaamino na asidi yellowing.Oolic ni triterpenoids pentacyclic pekee kutoka matunda ya swertia chinensis au Fructus ligustris na mtambo gentianaceae. Asidi oleanolic ni sana kupatikana katika mimea, na maudhui ya jumla ya 0.2% ~ 2% [1]. Maudhui ya chini ya kibuyu mara 1.5% ~ 2%, na maudhui ya matunda ya ligustris Fructus alikuwa 0.6% ~ 0.7%. Asidi oleanolic ni nyeupe acicular kioo (ethanol), odorless na dufu. Msimamo wa asidi na besi. Kiwango myeyuko ya 308 ~ 310 ℃, [alpha] 20 d + 73.3 ° (c = 0.15, klorofomu, hakuna katika maji, mumunyifu katika methanoli, pombe, ether, asetoni na chloroform.Oleanolic asidi triterpenoid kawaida kutokea, sana kusambazwa chakula na dawa ya mimea, kuhusiana na asidi betulinic. ni inaweza kupatikana katika Phytolacca americana (Marekani pokeweed), na Mizambarau spp, vitunguu, nk ni ya juu kiasi yasiyo ya sumu, hepatoprotective, na maonyesho antitumor na mali kuzuia virusi.
    acid oleanolic mara kupatikana kwa kuonyesha nguvu shughuli za kupambana na virusi vya ukimwi, kuhusiana na kiwanja asidi betulinic ilitumika kujenga ya kwanza ya kibiashara kukomaa kiviza madawa ya kulevya Ni mara ya kwanza alisoma na kutengwa kutoka kwa mimea kadhaa, ikiwa ni pamoja na Rosa woodsii (majani), Prosopis glandulosa (majani na matawi)., Phordendron juniperinum (kupanda kwa ujumla), Mizambarau claviflorum (majani), Hyptis capitata (kupanda kwa ujumla), na Ternstromia gymnanthera (angani sehemu). Mizambarau aina nyingine ikiwa ni pamoja na java apple (Mizambarau samarangense) na ilipanda tofaa s kuudhibiti.

     

    Bidhaa Jina: oleanolic Acid  98 %

    Vipimo: 98% na HPLC

    Botanic Chanzo: Olea Europea Dondoo

    Kemikali Jina: (3β) -3-Hydroxyolean-12-en-28 OIC asidi

    CAS No: 508-02-1

    Sehemu Imetumika: Leaf

    Michezo: White unga na harufu tabia na ladha

    GMO Hali: GMO Free

    Ufungashaji: katika 25kgs fiber ngoma

    Uhifadhi: Weka chombo unopened mahali baridi, kavu, kuweka mbali na mwanga na nguvu

    Shelf Maisha: miezi 24 kutoka tarehe ya uzalishaji

     

    What is oleanolic acid?

    Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

    Oleanolic acid structure

    Where can you find oleanolic acid?

    Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

    Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

    oleanolic acid sources

    Herb Name Oleanolic acid content Test method
    Ligustrum lucidum Ait 0.8028% HPLC
    Verbena Officinalis L 0.071%-0.086% HPLC
    Prunella vulgaris L 3.47%-4.46% HPLC
    Hemsley Chinensis Cogn. 1.5%~2% HPLC

    Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

    Hemsley Chinensis Cogn. Introduction

    Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

    Familia: Cucurbitaceae

    Tribus: Gomphogyneae

    Genus: Hemsleya

    Species: H. amabilis

    The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

    Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

    Medicinal Values:

    Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

    Hemsleya chinensis Cogn

    Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

    Oleanolic acid manufacturing

    Formulas containing Oleanolic acid in Food supplements

    We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

    • Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
    • Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
    • Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

    Oleanolic acid FORMULA

    Oleanolic acid VS Ursolic acid

    Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

    These triterpenoids compounds are known to exist in medicinal herbs and foods.

    They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

    Oleanolic acid VS Ursolic acid comparison

    OA and UA difference:

    Bidhaa Jina Oleanolic acid Ursolic acid
    CAS NO. 508-02-1 77-52-1
    Pentacyclic triterpenes  β-Amyrin α-Amyrin
    Herb sources Loquat leaf, Holy Basil, Rosemary, Olive leaf.etc.
    Specifications 40%,98%powder 15%,25%,50%,98%powder
    Appearance(color and odor) 40% light yellow98%white powderodorless 15%-50% brown-yellow or yellow98%white powderCharacteristic
    Distinguishing IR:(1355~1392cm-1) two peaks(1245~1330cm-1) three peaksNMR:δ(C12)122.1,δ(C13)143.4 (1355~1392cm-1) three peaks(1245~1330cm-1) three peaksδ(C12)125.5,δ(C13)138.0
    Derivatives Oleanolic sodium saltOleanolic acid phosphate disodium salt3-oxo oleanolic acid

    bardoxolone methyl (CDDO-Me)

    Ursolic sodium salt and its dicarboxylic acid half ester derivativesUrsolic acid ketene derivatives3-carbon ursolic acid

    3-acetoxyursolic acid

    Potential anticancer UA is more popular than OA.

    Biological Activities of Oleanolic Acid

    1. Anti-Tumour/Anti-Cancer Effects

    Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

     – by Xin Wang, Hua Bai, etc. Researchers

    OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

    OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

    OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

    OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

    In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

    Oleanolic Acid benefits

    1. Antimicrobial Activity

    OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

    OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

    1. Hepatoprotective Ability

    One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

    In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

    Oleanolic Acid and its derivatives

    Oleanolic Acid and its derivatives

    Oleanolic Acid Clinical Trials

    Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

    Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

     

    Chinese Pharmacopoeia Standard of Oleanolic Acid

    Jina la bidhaa Oleanolic Acid
    Kitambulisho (1)Take 30mg of this product, put it in a test tube, add 3ml of chloroform to dissolve, add two drops of sulfuric acid, shake for 5 minutes, the chloroform layer is purple-red.
    (2)Take about 20mg of this product, add 1ml of acetic anhydride, dissolve it with a slight heat, add sulfuric acid to the purple color, and darken after placing.
    (3)Take about 10mg of this product, add vanillin glacial acetic acid solution (take vanillin 0.5g, add 10ml of glacial acetic acid to dissolve, that is) 0.2ml, add 0.8ml of perchloric acid, and heat it for several minutes in a water bath. Fuchsia, add 2ml of ethyl acetate, purple-red dissolved in ethyl acetate, placed without discoloration.
    (4)The infrared absorption spectrum of this product should be consistent with the control spectrum.
    Determination of assay Take 0.15g of this product, accurately weigh it, add 30ml of ethanol, shake it, heat it in a warm water bath to dissolve, let cool to room temperature, add 3 drops of phenolphthalein indicator solution, make potassium hydroxide solution with ethanol (0.05mol/L) Titrate immediately and correct for blank test. Potassium hydroxide solution (0.05 mol/L) per 1 ml of ethanol corresponds to 22.84 mg of C30H 48O 3.

    Oleanolic acid recommend dosage

    According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

    Oleanolic acid side effects

    Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

    If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

    Please consult your physician or pharmacist before using this product.

    kazi:

    Asidi 1.Oleanolic ni ya juu kiasi yasiyo ya sumu, kupambana tumor, na hepatoprotective, pamoja na kuonyesha mali kuzuia virusi.
    Asidi 2.Oleanolic alionekana kuonyesha nguvu shughuli za kupambana na UKIMWI.
    Asidi 3.Oleanolic ni mlinzi mkubwa wa seli dhidi uoksidishaji na dhiki electrophile.
    Asidi 4.Oleanolic ina athari kubwa juu ya trating virusi hepatitis, papo hapo icteric hepatitis na hepatitis sugu.
    maombi:
    1. Applied katika uwanja wa chakula, inaweza kazi kama malighafi ya chai ya kupunguza kohozi,
    2. Applied katika uwanja dawa, inakuwa mpya ya kupambana na kansa ya madawa ya kulevya na sumu ya chini,
    3. Applied katika uwanja vipodozi, inaweza invigorate mzunguko wa damu na kuondoa Vinywaji.

     

     

     

    Habari zaidi za TRB

    Udhibiti vyeti
    USFDA, CEP, Kosher HALAL GMP ISO vyeti
    kuaminika Quality
    Takriban miaka 20, kuuza nje ya nchi 40 na mikoa, zaidi ya 2000 makundi zinazozalishwa na TRB hawana matatizo yoyote ubora, kipekee mchakato utakaso, uchafu na kudhibiti usafi kukutana USP, EP na CP
    Comprehensive Quality System

     

    ▲ Quality Assurance System

    ▲ Document kudhibiti

    ▲ Validation System

    ▲ Mafunzo System

    ▲ Ndani Itifaki ya Ukaguzi

    ▲ suppler ya Ukaguzi System

    ▲ Vifaa Vifaa System

    ▲ Material Control System

    ▲ uzalishaji Control System

    ▲ Ufungaji Uwekaji System

    ▲ Laboratory Control System

    ▲ Uhakiki Validation System

    ▲ Udhibiti wa Mambo System

    Kudhibiti nzima Vyanzo na Taratibu
    Madhubuti kudhibitiwa wote malighafi, vifaa na ufungaji materials.Preferred vifaa na vifaa na ufungaji vifaa ghafi muuzaji na Marekani DMF number.Several wauzaji malighafi vile usambazaji wa uhakika.
    Nguvu Taasisi Cooperative kusaidia
    Taasisi ya botania / Taasisi ya mikrobiolojia / Chuo cha Sayansi na Teknolojia / University

     


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